Interferon-γ downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral squamous cell carcinoma lines

Cell Death and Differentiation

Volumn 10, Issue 3, 2003, Pages 313-322

  Yonekura, N ^a   Yokota, S ^a   Yonekura, K ^a   Dehari, H ^a   Arata, S ^b   Kohama, G ^a   Fujii, N ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

Cisplatin; Hsp27; Interferon ; Molecular chaperone; Oral squamous cell carcinoma

Indexed keywords

ALPHA INTERFERON; ANTINEOPLASTIC AGENT; CASPASE 3; CHAPERONE; CISPLATIN; DNA; GAMMA INTERFERON; GLYCINE; HEAT SHOCK PROTEIN 27; MUTANT PROTEIN; SERINE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; CELL VIABILITY; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; DRUG EFFECT; DRUG POTENTIATION; DRUG SENSITIZATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MOLECULAR CLONING; MOUTH CARCINOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SQUAMOUS CELL CARCINOMA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATOGRAPHY, GEL; CISPLATIN; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, DOMINANT; HEAT-SHOCK PROTEINS; HUMANS; INTERFERON TYPE II; MICROSCOPY, ELECTRON; MOLECULAR CHAPERONES; MOUTH NEOPLASMS; MUTATION; NEOPLASM PROTEINS; PHENOTYPE; PLASMIDS; TIME FACTORS;

EID: 0038297011     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401169     Document Type: Review

References (49)

1. Rosenberg B. (1985) Fundamental studies with cisplatin. Cancer 55: 2303-2306
2. Nehme A, Julia AM, Jozan S, Chevreau C, Bugat R and Canal P. (1994) Modulation of cisplatin cytotoxicity by human recombinant interferon-γ in human ovarian cancer cell lines. Eur. J. Cancer 4: 520-525
3. Lee SB and Esteban M (1994) The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis. Virology 199: 491-496
4. Diaz-Guerra M, Rivas C and Esteban M (1997) Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells. Virology 236: 354-363
5. Yeung MC, Liu J and Lau AS (1996) An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells. Proc. Natl. Acad. Sci. USA 93: 12451-12455
6. Zhou A, Paranjape J, Brown TL, Nie H, Naik S, Dong B, Chang A, Trapp B, Fairchild R, Colmenares C and Silverman, RH (1997) Interferon action and apoptosis are defective in mice devoid of 2′,5′-oligoadenylate-dependent RNase L. EMBO J. 16: 6355-6363
7. Yonekura N, Yokosawa N, Hariya Y, Dehari H, Kohama G and Fujii N (2000) Interferon-alpha and interferon-gamma augment apoptosis in oral carcinoma cells treated with Shiga toxin 2 (Stx2). Tumor Res. 35: 25-33
8. Gething M-J, ed. (1997) Guidebook to Molecular Chaperones and Protein-Folding Catalysts. Oxford: Oxford University Press
9. Creagh EM, Sheehan D and Cotter TG (2000) Heat shock proteins-modulators of apoptosis in tumor cells. Leukemia 14: 1161-1173
10. Jolly C and Morimoto RI (2000) Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J. Natl. Cancer Inst. 92: 1564-1572
11. Sõti C and Csermely P (1998) Molecular chaperones in the etiology and therapy of cancer. Pathol. Oncol. Res. 4: 316-321
12. Samali A and Orrenius S (1998) Heat shock proteins: regulators of stress response and apoptosis. Cell Stress Chaperones 3: 228-236
13. Xanthoudakis S and Nicholson DW (2000) Heat-shock proteins as death determinants. Nat. Cell Biol. 2: E163-E165
14. Leist M and Jäättelä M (2001) Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell Biol. 2: 589-598
15. Yokoi T, Yamaguchi A, Odajima T and Furukawa K (1988) Establishment and characterization of a human cell line derived from a oral sqamous carcinoma of the tongue. Tumor Res. 23: 46-57
16. Yokoi T, Hirata S, Nishimura F, Miyakawa A, Odajima T, Kohama G and Mochizuki Y (1990) Some properties of a newly established human cell line derived from an oral squamous carcinoma. Tumor Res. 25: 93-103
17. Miyazaki A, Sato N, Takahashi S, Sasaki A, Kohama G, Yamaguchi A, Yagihashi A and Kikuchi K (1997) Cytotoxicity of histocompatibility leukocyte antigen-DR8-restricted CD4 killer T cells against human autologous squamous cell carcinoma. Jpn. J. Cancer Res. 88: 191-197
18. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254
19. Yokosawa N, Kubota T and Fujii N (1998) Poor induction of interferon-induced 2′,5′-oligoadenylate synthetase (2-5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT-1α. Arch. Virol. 143: 1985-1992
20. Yokota S, Yanagi H, Yura T and Kubota H (2000) Upregulation of cytosolic chaperonin CCT subunits during recovery from chemical stress that causes accumulation of unfolded proteins. Eur. J. Biochem. 267: 1658-1664
21. Arata S, Hamaguchi S and Nose K (1995) Effects of the overexpression of the small heat shock protein, HSP27, on the sensitivity of human fibroblast cells exposed to oxidative stress. J. Cell Physiol. 163: 458-465
22. Arata S, Hamaguchi S and Nose K (1997) Inhibition of colony formation of NIH 3T3 cells by the expression of the small molecular weight heat shock protein HSP27: involvement of its phosphorylation and aggregation at the C-terminal region. J. Cell Physiol. 170: 19-26
23. Landry J, Lambert H, Zhou M, Lavoie JN, Hickey E, Weber LA and Anderson CW (1992) Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J. Biol. Chem. 267: 794-803
24. Hariya Y, Shirakawa S, Yonekura N, Yokosawa N, Kohama G and Fujii N (1999) Augmentation of verotoxin-induced cytotoxicity/apoptosis by interferon is repressed in cells persistently infected with mumps virus. J. Interferon Cytokine Res. 19: 479-485
25. Thornberry NA and Lazebnik Y (1998) Caspases: enemies within. Science 281: 1312-1316
26. Beere HM and Green DR (2001) Stress management - heat shock protein-70 and the regulation of apoptosis. Trends Cell Biol. 11: 6-10
27. Atkinson EA, Barry M, Darmon AJ, Shostak I, Turner PC, Moyer RW and Bleackley RC (1998) Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B. J. Biol. Chem. 273: 21261-21266
28. Van de Craen M, Van den Brande I, Declercq W, Irmler M, Beyaert R, Tschopp J, Fiers W and Vandenabeele P (1997) Cleavage of caspase family members by granzyme B: a comparative study in vitro. Eur. J. Immunol. 27: 1296-1299
29. Huot J, Roy G, Lambert H, Chretien P and Landry J (1991) Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein. Cancer Res. 51: 5245-5252
30. Oesterreich S, Weng CN, Qiu M, Hilsenbeck SG, Osborne CK and Fuqua SA (1993) The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Res. 53: 4443-4448
31. Garrido C, Ottavi P, Fromentin A, Hammann A, Arrigo AP, Chauffert B and Mehlen P (1997) HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs. Cancer Res. 57: 2661-2667
32. Rogalla T, Ehrnsperger M, Previllé X, Kotlyarov A, Lutsch G, Ducasse C, Paul C, Wieske M, Arrigo AP, Buchner J and Gaestel M (1999) Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation. J. Biol. Chem. 274: 18947-18956
33. Mehlen P, Hickey E, Weber LA and Arrigo AP (1997) Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFα in NIH-3T3-ras cells. Biochem. Biophys. Res. Commun. 241: 187-192
34. Kaur J, Kaur J and Ralhan R (2000) Induction of apoptosis by abrogation of HSP70 expression in human oral cancer cells. Int. J. Cancer 85: 1-5
35. Nylandsted J, Rohde M, Brand K, Bastholm L, Elling F and Jäättelä M (2000) Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2. Proc. Natl. Acad. Sci. USA 97: 7871-7876
36. Stokoe D, Engel K, Campbell DG, Cohen P and Gaestel M (1992) Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett. 313: 307-313
37. Ludwig S, Engel K, Hoffmeyer A, Sithanandam G, Neufeld B, Palm D, Gaestel M and Rapp UR (1996) 3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways. Mol. Cell. Biol. 16: 6687-6697
38. Bruey J-M, Ducasse C, Bonniaud P, Ravagnan L, Susin SA, Diaz-Latoud C, Gurbuxani S, Arrigo A-P, Kroemer G, Solary E and Garrido C (2000) Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat. Cell Biol. 2: 645-652
39. Benndorf R, Hayess K, Ryazantsev S, Wieske M, Behlke J and Lutsch G (1994) Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity. J. Biol. Chem. 269: 20780-20784
40. Lavoie JN, Gingras-Breton G, Tanguay RM and Landry J (1993) Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock* HSP27 stabilization of the microfilament organization. J. Biol. Chem. 268: 3420-3429
41. Mehlen P, Schulze-Osthoff K and Arrigo AP (1996) Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death. J. Biol. Chem. 271: 16510-16514
42. Previllé X, Salvemini F, Giraud S, Chaufour S, Paul C, Stepien G, Ursini MV and Arrigo AP (1999) Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery. Exp. Cell Res. 247: 61-78
43. Garrido C, Bruey JM, Fromentin A, Hammann A, Arrigo AP and Solary E (1999) HSP27 inhibits cytochrome c-dependent activation of procaspase-9. FASEB J. 13: 2061-2070
44. Pandey P, Farber R, Nakazawa A, Kumar S, Bharti A, Nalin C, Weichselbaum R, Kufe D and Kharbanda S (2000) Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3. Oncogene 19: 1975-1981
45. Charette SJ, Lavoie JN, Lambert H and Landry J (2000) Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol. Cell. Biol. 20: 7602-7612
46. Gaestel M, Gotthardt R and Muller T (1993) Structure and organisation of a murine gene encoding small heat-shock protein Hsp25. Gene 128: 279-283
47. Jäättelä M (1999) Escaping cell death: survival proteins in cancer. Exp. Cell Res. 248: 30-43
48. Jäättelä M (1999) Heat shock proteins as cellular lifeguards, Ann. Med. 31: 261-271
49. Arrigo AP (2000) sHsp as novel regulators of programmed cell death and tumorigenicity. Pathol. Biol. 48: 280-288