Regulation of gene transcription by a constitutively active mutant of activating transcription factor 2 (ATF2)

Biological Chemistry

Volumn 384, Issue 4, 2003, Pages 667-672

  Steinmüller, Lars ^a   Thiel, Gerald ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

ATF2; ATF4; c Jun; CREB2; Fas ligand; Tumor necrosis factor

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FAS LIGAND; LEUCINE ZIPPER PROTEIN; MUTANT PROTEIN; PROTEIN C JUN; PROTEIN FOS; THREONINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DNA BINDING MOTIF; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ACTIVATING TRANSCRIPTION FACTOR 2; BLOTTING, WESTERN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION; GENES, JUN; HUMANS; MEMBRANE GLYCOPROTEINS; MUTATION; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0038296940     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2003.074     Document Type: Article

References (34)

1. Benbrook, D.M., and Jones, N.C. (1990). Heterodimer formation between CREB and JUN proteins. Oncogene 5, 295-302.
2. Benbrook, D.M., and Jones, N.C. (1994). Different binding specificities and transactivation of variant CRE's by CREB complexes. Nucleic Acids Res. 22, 1463-1469.
3. Cheong, J.H., Coligan, J.E., and Shuman, J.D. (1998). Activating transcription factor-2 regulates phosphoenolpyruvat carboxykinase transcription through a stress-inducible mitogen-activated protein kinase pathway. J. Biol. Chem. 273, 22714-22718.
4. Chevray, P.M., and Nathans, D. (1992). Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc. Natl. Acad. Sci. USA 89, 5789-5793
5. Cibelli, G., Policastro, V., Rössler, O.G., and Thiel, G. (2002). Nitric oxide-induced programmed cell death in human neuroblastoma cells is accompanied by the synthesis of Egr-1, a zinc finger transcription factor. J. Neurosci. Res. 67, 450-460.
6. Eichhorst, S.T., Müller, M., Li-Weber, M., Schulze-Bergkamen, H., Angel, P, and Krammer, P.H. (2000). A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs. Mol. Cell. Biol. 20, 7826-7837.
7. Falvo, J.V., Uglialoro, A.M., Brinkman, B.M.N., Merika, M., Parekh, B.S., Tsai, E.Y., Morielli, A.D., Peralta, E.G., Maniatis, T., Thanos, D., and Goldfeld, A.E. (2000). Stimulus-specific assembly of enhancer complexes on the tumor necrosis-α gene promoter. Mol. Cell. Biol. 20, 2239-2247.
8. Groot, M., Boxer, L. M, and Thiel, G. (2000). Nerve growth factor- and epidermal growth factor-regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma cells. Eur. J. Cell Biol. 79, 924-935.
9. Gupta, S., Campbell, D., Dérijard, B., and Davis, R.J. (1995). Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267, 389-393.
10. Hai, T., and Curran, T. (1991). Cross-family dimerization of transcription factors fos/jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. USA 88, 3720-3724.
11. Jüngling, S., Cibelli, G., Czardybon, M., Gerdes, H.-H., and Thiel, G. (1994). Differential regulation of chromogranin B and synapsin I gene promoter activity by cAMP and cAMP-dependent protein kinase. Eur. J. Biochem. 226, 925-935.
12. Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., and Green, D.R. (1998). DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-κB and AP-1. Mol. Cell 1, 543-551.
13. Kaufmann, K., and Thiel, G. (2002). Epidermal growth factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1, a zinc finger transcriptional regulator. J. Cell. Biochem. 85, 381-391.
14. Kim, S.-J., Wagner, S., Liu, F., O'Reilly, M.A., Robbins, P.D., and Green, M.R. (1992). Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2. Nature 358, 331-334.
15. Krammer, P.H. (2000). CD95's deadly mission in the immune system. Nature 407, 789-795.
16. Leppä, S., Eriksson, M., Saffrich, R., Ansorge, W., and Bohmann, D. (2001). Complex functions of AP-1 transcription factor in differentiation and survival of PC12 cells. Mol. Cell. Biol. 21, 4369-4378.
17. Li, X.-Y., and Green, M.R. (1996). Intramolecular inhibition of activating transcription factor-2 function by its DNA-binding domain. Genes Dev. 10, 517-527.
18. Livingstone, C., Patel, G., and Jones, N. (1995). ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J. 14, 1785-1797.
19. Maekawa, T., Bernier, F., Sato, M., Nomura, S., Singh, M., Inoue, Y., Tokunaga, T., Imai, H., Yokoyama, M., Reimold, A., Glimcher, L.H., and Ishii, S. (1999). Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome. J. Biol. Chem. 274, 17813-17819.
20. Mittelstadt, P.R., and Ashwell, J.D. (1998). Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression. Mol. Cell. Biol. 18, 3744-3751.
21. Nomura, N., Zu, Y.-L., Maekawa, T., Tabata, S., Akiyama, T., and Ishii, S. (1993). Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1. J. Biol. Chem. 268, 4259-4266.
22. Ouwens, D.M., de Ruiter, N.D., an der Zon, G.C.M., Carter, A.P., Schouten, J., van der Burgt, C., Kooistra, K., Bos, J.L., Maassen, J.A., and van Dam, H. (2002). Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. EMBO J. 21, 3782-3793.
23. Reimold, A.M., Grusby, M.J., Kosarars, B., Fries, J.W. U., Mori, R., Maniwa, S., Clauss, I.M., Collins, T., Sidman, R.L., Glimcher, M.J., and Glimcher, L.H. (1996). Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Nature 379, 262-265.
24. Rhoades, K.L., Golub, S.H., and Economou, J.S. (1992). The regulation of the human tumor necrosis factor α promoter region in macrophages, T cell, and B cell lines. J. Biol. Chem. 267, 22102-22107.
25. Sano, Y., Harada, J., Tashiro, S., Gotoh-Mandeville, R., Maekawa, T., and Ishii, S. (1999). ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-β-signaling. J. Biol. Chem. 274, 8949-8957.
26. Schoch, S., Cibelli, G., Magin, A., Steinmüller, L., and Thiel, G. (2001). Modular structure of cAMP response element binding protein 2 (CREB2). Neurochem. Int. 38, 601-608.
27. Shimizu, M., Nomura, Y., Suzuki, H., Ichikawa, E., Takeuchi, A., Suzuki, M., Nakamura, T., Nakajima, T., and Oda, K. (1998). Activation of the rat cyclin A promoter by ATF2 and Jun family members and its suppression by ATF4. Exp. Cell Res. 239, 93-103.
28. Shuman, J.D., Cheong, J., and Coligan, J.E. (1997). ATF-2 and C/EBPa can form a heterodimeric DNA binding complex in vitro. Functional implications for transcriptional regulation. J. Biol. Chem. 272, 12793-12800.
29. Steinmüller, L., Cibelli, G., Moll, J.R., Vinson, C., and Thiel, G. (2001). Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities. Biochem. J. 360, 599-607.
30. Thiel, G., Greengard, P., and Südhof, T.C. (1991). Characterization of tissue-specific transcription by the human synapsin I gene promoter. Proc. Natl. Acad. Sci. USA 88, 3431-3435.
31. Thiel G., Kaufmann K., Magin A., Lietz M., Bach K., and Cramer M. (2000). The human transcriptional repressor protein NAB1: expression and biological activity. Biochim. Biophys. Acta 1493, 289-301.
32. Tsai, E.Y., Jain, J., Pesavento, P.A., Rao, A., and Goldfeld, A.E. (1996). Tumor necrosis factor-α gene regulation in activated T cells involves ATF2/Jun and NFATp. Mol. Cell. Biol. 16, 459-467.
33. van Dam, H., Duyndam, M., Rottier, R., Bosch, A., de Vries-Smits, L., Herrlich, P., Zantema, A., Angel, P., van der Eb, A. J. (1993). Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus protein. EMBO J. 12, 479-487.
34. van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlich, P., and Angel, P. (1995). ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14, 1798-1811.