The HET-CAM test combined with histological studies for better evaluation of active ingredient innocuity

International Journal of Tissue Reactions

Volumn 24, Issue 4, 2002, Pages 117-121

  Djabari, Z ^a   Bauza, E ^a   Dal Farra, C ^a   Domloge, N ^a  

^a Vincience Research Center   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COSMETIC; EOSIN; HEMATOXYLIN; TRYPAN BLUE;

ANIMAL TESTING ALTERNATIVE; ARTICLE; BIOTECHNOLOGICAL PROCEDURES; BLEEDING; BLOOD CLOTTING; CHEMICAL ANALYSIS; CHORIOALLANTOIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DILUTION; DRUG HYPERSENSITIVITY; DRUG PURITY; EGG; HEN EGG TEST ON CHORIOALLANTOIC MEMBRANE; HISTOLOGY; HYPEREMIA; IN VIVO STUDY; INCUBATION TIME; MICROSCOPY; NONHUMAN; OBSERVATION; PREVENTIVE MEDICINE; SENSITIVITY AND SPECIFICITY; SKIN IRRITATION; STAINING; TOXICITY TESTING;

ALLANTOIS; ANIMAL TESTING ALTERNATIVES; ANIMALS; CHICKENS; CHORION; FEMALE; IRRITANTS; SENSITIVITY AND SPECIFICITY; TOXICITY TESTS;

ANIMALIA;

EID: 0038287931     PISSN: 02500868     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Luepke N.P. Hen's egg chorioallantoic membrane test for irritation potential. Food Chem. Toxicol., 23, 2, 1985.
2. Vesely D., Vesela D., Jelinek R. The bioavailability of substances administered to chick embryos: The maximum effective route of administration. ATLA, 25, 655, 1997.
3. Luepke N.P. The Hen's egg test (HET): An alternative toxicity test. Brit. J. Dermatol., 115, 133, 1986.
4. Luepke N.P. Kempler F.H. The HET-CAM test: An alternative to the Draize eye test. Food Chem. Toxicol., 24, 495, 1986.
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6. Ribatti D., Gualandris A., Bastaki K., et al. New model for the study of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane: The gelatin sponge/chorioallantoic membrane assay. J. Vasc. Res., 34, 455, 1997.
7. Herbert J.G., Micjael T.V., Burger P.C., Klintworth G.K. Effect of irradiation on vascularization of corneas grafted onto chorioallantoic membranes. Invest. Ophthalmol. Vis. Sci., 26, 1533, 1985.
8. Darnnhardt G., Kreher M., Nowe U., Pies A. Method for testing non-steroidal anti-inflammatories: The modified hen's egg chorioallantoic membrane test (HET-CAM) compared to other procedures. Arch. Pharm. Pharm. Med. Chem., 329, 301, 1996.