Method for testing non-steroidal anti-inflammatories: The modified hen's egg chorioallantoic membrane test (HET-CAM test) compared to other procedures

Archiv der Pharmazie

Volumn 329, Issue 6, 1996, Pages 301-310

  Dannhardt, Gerd ^a   Kreher, Mareta ^a   Nowe, Ulrike ^a   Pies, Andreas ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

commercial non steroidal anti inflammatory products; determination of anti inflammatory potency; HET CAM test; scope and limitations of use

Indexed keywords

DICLOFENAC; FLUFENAMIC ACID; IBUPROFEN; INDOMETACIN; KETOPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PHENYLBUTAZONE; PIROXICAM; SALICYLATE SODIUM; SALICYLIC ACID;

ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHICKEN; CHORIOALLANTOIS; DOSE RESPONSE; DRUG POTENCY; DRUG SCREENING; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHORION; COMPARATIVE STUDY; DIFFUSION; EGG; METABOLISM; METHODOLOGY; TIME; TOXICITY TESTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHICKENS; CHORION; DIFFUSION; DOSE-RESPONSE RELATIONSHIP, DRUG; EGGS; MOLECULAR STRUCTURE; TIME FACTORS; TOXICITY TESTS;

EID: 0030163391     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.19963290606     Document Type: Article

References (35)

1. Part 19: G. Dannhardt, W. Kiefer, U. Nowe, Arch. Pharm. (Weinheim) 1995, 325, 681-686.
2. N.P. Lüpke in Möglichkeiten und Grenzen der Reduktion von Tierversuchen (Eds.: H. Schöffl, R. Schulte-Herrmann, H.A. Tritthart), Springer Verlag Wien, New York 1992, pp 37-49.
3. F. Kemper, Arzneim.-Forsch. (Drug Res.) 1963, 13, 191-194.
4. B. Clement, C. Mladek, Arch. Pharm. (Weinheim) 1993, 326, 689.
5. N.P. Lüpke, Pharm. Ztg. Wis. 1992, 6, 221-233.
6. N.P. Lüpke, N.L. Theissen, G. Baron, Arch. Pharm. (Weinheim) 1990, 323, 798.
7. F. Petereit, A. Nahrstedt, B. Innerlich, N.P. Lüpke, N.L. Theissen, H. Winterhoff, Arch. Pharm. (Weinheim) 1989, 322, 750.
8. N.P. Lüpke in: Betahydroxyethylrutoside. Neue Ergebnisse aus Pharmakologie und Klinik, Medikon-Verlag, München, 1990.
9. Goodman & Gillman's The Pharmacological Basis of Therapeutics, 8th Ed., McGraw-Hill, NY 1992, pp. 1442.
10. Martindale, The Extra Pharmacopöe, 29th Ed., The Pharmaceutical Press, London, 1989, p. 1610.
11. A. Laut, Drugs 1985, 29, 57-87.
12. C.A. Winter, E.A. Risley, G.W. Nuss, Proc. Exp. Bio. Med. 1962, 111, 544-562.
13. K. Mörsdorf, G. Wolf, Arzneim.-Forsch. (Drug Res.) 1972, 22, 2105-2110.
14. G. Dannhardt, M. Lehr, J. Pharm. Pharmacol. 1992, 44, 419-424.
15. R.O. Day, G.G. Graham, K.M. Williams, Drugs 1988, 36, 643-651.
16. K. McCormack, K. Brune, Drugs 1991, 41, 533-547.
17. R.N. Brogden, R.C. Heel, Drugs 1984, 28, 292-323.
18. J.H. Hermann, A.M. Appel, R.C. Khosla, Rheum. 1989, 16, 75-81.
19. T.G. Kantor, Pharmacother. 1986, 6, 93-103.
20. K. Brune, K.D. Rainsford, K. Wagner, B.A. Peskar, Naunyn-Schmiedeberg's Arch. Pharmacol. 1981, 375, 269-278.
21. S.L. Ali, T. Strittmaier, Pharm. Ztg. 1978, 123, 720-723.
22. F. Matsui, D.L. Robertson, M.A. Poirier, J. Pharm. Sci. 1980, 69, 469-471.
23. S. Ebel, Würzburger Schriften zur Analytik, 4. Aufl. 1992, pp. 3, 25.
24. R. Malisch, Z. Lebensm. Unters. Forsch. 1986, 182, 385-399.
25. R. Malisch, Z. Lebensm. Unters. Forsch. 1986, 183, 253-266.
26. G. Dannhardt, W. Kiefer, U. Nowe, unpublished results.
27. E.H. Wiseman, Y.H. Chang,J.G. Lombardino,Arzneim.-Forsch. (Drug Res.) 1976, 26, 1300-1303.
28. W. Calhoun, J. Chang, R.P. Carlson, Agents Actions 1984, 21, 306-309.
29. P. Schianterelli, S. Cadel, Arzneim.-Forsch. (Drug Res.) 1981, 31, 87-92.
30. R. Menassé, P.R. Hedwall, J. Kraetz, Scand. J. Rheum. 1978, 22 (Suppl.), 5-16.
31. L. Julou, J.C. Guyonnet, R. Ducrot, J. Pharmacol. 1971, 2, 259-262.
32. K. Hirose, H. Jyoyama, Y. Kojima, M. Eigyo, Arzneim.-Forsch. (Drug Res.) 1984, 34, 280-286.
33. K.C. Yeh, Am. J. Med. 1985, 79 (Suppl. 4c), 3-12.
34. R.N. Brogden, R.C. Heel, Drugs 1980, 20, 24-48.
35. Pharmazeutische Stoffliste, Arzneibüro der ABDA, Werbe- und Vertriebsgesellschaft Deutscher Apotheker m.b.H, 9. Aufl., Eschborn/Taunus, 1994.