Ethyl arachidonate is the predominant fatty acid ethyl ester in the brains of alcohol-intoxicated subjects at autopsy

Lipids

Volumn 38, Issue 3, 2003, Pages 269-273

  Refaai, M A ^a   Nguyen, P N ^a   Cluette Brown, J E ^a   Laposata, M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; BLOOD; BRAIN; ESTERS; ETHANOL; METABOLITES; TISSUE CULTURE;

DESATURATION;

OLEIC ACID;

ALCOHOL; ARACHIDONIC ACID; ARACHIDONIC ACID DERIVATIVE; ARACHIDONIC ACID ETHYL ESTER; FATTY ACID ESTER; LINOLEIC ACID; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ALCOHOL BLOOD LEVEL; ALCOHOL INTOXICATION; ARTICLE; AUTOPSY; BRAIN; BRAIN WEIGHT; CLINICAL ARTICLE; FATTY ACID DESATURATION; FATTY ACID SYNTHESIS; HUMAN; HUMAN TISSUE; LIVER; METABOLITE; PRECURSOR; SCREENING TEST; TISSUE INJURY;

ADIPOSE TISSUE; ALCOHOLIC INTOXICATION; ARACHIDONIC ACIDS; AUTOPSY; BRAIN; ETHANOL; HUMANS; LINOLEIC ACIDS; LIVER;

EID: 0038286285     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11745-003-1060-6     Document Type: Article

References (22)

1. Newsome, W.H., and Rattray, J.B.M. (1965) The Enzymatic Esterification of Ethanol with Fatty Acids, Can. J. Biochem. 43, 1223-1233.
2. Goodman, D.S., and Deykin, D. (1963) Fatty Acid Ethyl Ester Formation During Ethanol Metabolism in vivo, Proc. Soc. Exp. Biol. Med. 113, 65-70.
3. Lange, L.G., Bergmann, S.R., and Sobel, R.E. (1981) Identification of Fatty Acid Ethyl Esters as Products of Myocardial Ethanol Metabolism, J. Biol. Chem. 256, 12968-12973.
4. Laposata, M., Szczepiorkowski, Z.M., and Cluette-Brown, J.E. (1995) Fatty Acid Ethyl Esters: Non-oxidative Metabolites of Ethanol, Prostaglandins Leukot. Essent. Fatty Acids 52, 87-91.
5. Laposata, E.A., and Lange, L.G. (1986) Presence of Nonoxidative Ethanol Metabolism in Human Organs Commonly Damaged by Ethanol Abuse, Science 231, 497-499.
6. Laposata, M. (1998) Fatty Acid Ethyl Esters: Ethanol Metabolites Which Mediate Ethanol-Induced Organ Damage and Serve as Markers of Ethanol Intake, Prog. Lipid Res. 37, 307-316.
7. Doyle, K.M., Bird, D.A., Al-Salihi, S., Hallaq, Y., Cluette-Brown, J.E., Goss, K.A., and Laposata, M. (1994) Fatty Acid Ethyl Esters Are Present in Human Serum After Ethanol Ingestion, J. Lipid Res. 35, 428-437.
8. Doyle, K.M., Cluette-Brown, J.E., Dube, D.M., Bernhardt, T.G., Morse, C.R., and Laposata, M. (1996) Fatty Acid Ethyl Esters in the Blood as Markers for Ethanol Intake, JAMA 276, 1152-1156.
9. Salem, R.O., Refaai, M.A., Cluette-Brown, J.E., and Laposata, M. (2001) Fatty Acid Ethyl Esters in Liver and Adipose Tissues as Postmortem Markers for Ethanol Intake, Clin. Chem. 47, 722-725.
10. Refaai, M.A., Nguyen, P.N., Steffensen, T.S., Evans, R.J., Cluette-Brown, J.E., and Laposata, M. (2002) Liver and Adipose Tissue Fatty Acid Ethyl Esters Obtained at Autopsy Are Postmortem Markers for Premortem Ethanol Intake, Clin. Chem. 48, 77-83.
11. Laposata, M., Kabakibi, A., Walden, M.P., Cluette-Brown, J.E., Nanji, A.A., Refaai, M.A., Werner, J., and Nanji, A.A. (2000) Differences in the Fatty Acid Composition of Fatty Acid Ethyl Esters in Organs and Their Secretions, Alcohol Clin. Exp. Res. 24, 1488-1491.
12. Laposata, E.A., Scherrer, D.E., and Lange, L.G. (1989) Fatty Acid Ethyl Esters in Adipose Tissues as a Laboratory Marker for Alcohol Related Death, Arch. Pathol. Lab. Med. 113, 762-766.
13. Abedin, L., Lien, E.L., Vingrys, A.J., and Sinclair, A.J. (1999) The Effects of Dietary α-Linolenic Acid Compared with Docosahexaenoic Acid on Brain, Retina, Liver, and Heart in the Guinea Pig, Lipids 34, 475-482.
14. Lien, E.L., Boyle, F.G., Yuhas, R.J., and Kuhlman, C.F. (1994) Effect of Maternal Dietary Arachidonic or Linoleic Acid on Rat Pup Fatty Acid Profiles, Lipids 29, 53-59.
15. Shetty, H.U., Smith, Q.R., Washizaki, K., Rapoport, S.I., and Purdon, A.D. (1996) Identification of Two Molecular Species of Rat Brain Phosphatidylcholine That Rapidly Incorporate and Turn Over Arachidonic Acid in vivo, J. Neurochem. 67, 1702-1710.
16. 14CLinoleic Acid Distribution in Various Tissue Lipids of Guinea Pigs Following an Oral Dose, Lipids 36, 255-260.
17. Lesch, P., Schmidt, E., and Schmidt, F.W. (1973) Effects of Chronic Alcohol Abuse on the Fatty Acid Compositon of Major Lipids in the Human Brain, Z. Klin. Chem. Klin. Biochem. 11, 159-166.
18. MacDonald, J.I., and Sprecher, H. (1991) Phospholipid Fatty Acid Remodeling in Mammalian Cells, Biochim. Biophys. Acta 1084, 105-121.
19. Reitz, R. (1993) Dietary Fatty Acids and Alcohol: Effects on Cellular Membranes, Alcohol Alcohol. 28, 59-71.
20. Corbett, R., Berthou, F., Leonard, B., and Menez, J. (1992) The Effects of Chronic Administration of Ethanol on Synaptosomal Fatty Acid Composition: Modulation by Oil Enriched with γ-Linolenic Acid, Alcohol Alcohol 27, 11-14.
21. Su, H.M., Corso, T.N., Nathanielsz, P.W., and Brenna, J.T. (1999) Linoleic Acid and Kinetics and Conversion to Arachidonic Acid in the Pregnant and Fetal Baboon, J. Lipid Res. 40, 1304-1312.
22. Spector, A.A. (2001) Plasma Free Fatty Acid and Lipoproteins as Sources of Polyunsaturated Fatty Acid for the Brain, J. Mol. Neurosci. 16, 159-165.