Conformational properties of nucleotide-based template-competitive HIV-1 reverse transcriptase inhibitors: Analysis of enzyme binding modes

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 3, 2003, Pages 283-297

  Lin, Weiying ^a   Li, Ke ^a   Moore, Bob M ^a,b   Doughty, Michael B ^a  

^a SOUTHEASTERN LOUISIANA UNIVERSITY   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Combined substrate inhibitors; DNA polymerase; Nucleotide conformation; Reverse transcriptase; Template competitive inhibitors

Indexed keywords

2 (4 AZIDOPHENACYL)THIO 1,N6 ETHENO 2' DEOXYADENOSINE 5' TRIPHOSPHATE; 2 (4 AZIDOPHENACYL)THIO 2' DEOXYADENOSINE 5' TRIPHOSPHATE; DNA POLYMERASE INHIBITOR; ENZYME INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; ENZYME INHIBITOR INTERACTION; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

BINDING, COMPETITIVE; DEOXYADENINE NUCLEOTIDES; HIV-1 REVERSE TRANSCRIPTASE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0038284101     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120021428     Document Type: Article

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