Compared with control subjects, the systemic sympathetic nervous system is activated in patients with mitral regurgitation

American Heart Journal

Volumn 145, Issue 6, 2003, Pages 1078-1085

  Mehta, Rajendra H ^a   Supiano, Mark A ^a   Oral, Hakan ^a   Grossman, P Michael ^a   Montgomery, Daniel S ^a   Smith, Marla J ^a   Starling, Mark R ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Cardiology Section   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC ACTIVITY; ADRENERGIC SYSTEM; ADULT; AGED; ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; CALCULATION; CLINICAL ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HEART CATHETERIZATION; HEART CINEVENTRICULOGRAPHY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE OVERLOAD; HUMAN; LUNG CAPILLARY PRESSURE; MALE; MITRAL VALVE REGURGITATION; NORADRENALIN RELEASE; PRIORITY JOURNAL; ANALYSIS OF VARIANCE; HEART VENTRICLE; METABOLISM; MIDDLE AGED; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; RADIOGRAPHY;

ADRENERGIC RECEPTOR STIMULATING AGENT; DIAGNOSTIC AGENT; NORADRENALIN;

ADULT; AGED; ANALYSIS OF VARIANCE; FEMALE; HEART CATHETERIZATION; HEART VENTRICLES; HUMANS; MALE; MIDDLE AGED; MITRAL VALVE INSUFFICIENCY; NOREPINEPHRINE; STATISTICS, NONPARAMETRIC; SYMPATHETIC NERVOUS SYSTEM; SYMPATHOMIMETICS;

EID: 0038281514     PISSN: 00028703     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-8703(03)00111-X     Document Type: Article

References (18)

1. Nagatsu M, Zile MR, Tsutsui H, et al. Native β-adrenergic support for left ventricular dysfunction in experimental mitral regurgitation normalizes indexes of pump and contractile function. Circulation 1994;89:818-26.
2. Tsutsui H, Spinale FG, Nugatsu M, et al. Effects of chronic β-adrenergic blockade on the left ventricular and cardiocyte abnormalities of chronic canine mitral regurgitation. J Clin Invest 1994;93:2639-48.
3. Starling MR, Kirsh MM, Montgomery DG, et al. Impaired left ventricular contractile function in patients with long-term chronic mitral regurgitation and normal ejection fraction. J Am Coll Cardiol 1993;22:239-50.
4. Hogikyan RV, Supiano MA. Arterial alpha-adrenergic responsiveness is decreased and SNS activity is increased in older humans. Am J Physiol 1994;266:E717-24.
5. Hogikyan RV, Supiano MA. Homologous upregulation of human arterial α-adrenergic responses by guanadrel. J Clin Invest 1993;256:72-178.
6. Linares OA, Jacquez JA, Zech LA, et al. Norepinephrine metabolism in humans: kinetic analysis and model. J Clin Invest 1987;80:1332-41.
7. Starling MR, Walsh RA. Accuracy of biplane axial oblique and oblique cineangiographic left ventricular cast volume determinations using a modification of Simpson's rule algorithm. Am Heart J 1985;110:1219-25.
8. Supiano MA, Linares OA, Smith MJ, et al. Age-differences in norepinephrine kinetics: effect of posture and sodium-restricted diet. Am J Physiol 1990;259:E422-31.
9. Linares OA, Zech LA, Jacques JA, et al. The effect of sodium-restricted diet and posture on norepinephrine kinetics in humans: compartmental analysis. Am J Physiol 1988;254:E222-30.
10. Stromberg JS, Linares OA, Supiano MA, et al. Effect of the tricyclic antidepressant desipramine on norepinephrine metabolism in humans: interaction with aging. Am J Physiol 1991;261:R1484-90.
11. Sekkari MA, Egan BM, Neubig RR, et al. Sensitization of human alpha1- and alpha2- adrenergic venous responses by guanadrel sulfate. Clin Pharmacol Ther 1990;48:537-43.
12. Rosen RG, Supiano MA, Perry TJ, et al. Beta-adrenergic blockade decreases norepinephrine release in humans. Am J Physiol 1990;258:E999-1005.
13. Evans MI, Halter JB, Porte D. Comparisons of double- and single-isotope enzymatic derivative methods for measuring catecholamines in human plasma. Clin Chem 1978;24:567-70.
14. Esler M, Jackman G, Bobik A, et al. Determination of norepinephrine apparent release rate and clearance in humans. Life Sci 1979;25:1461-70.
15. Kopin IJ, Rundqvist B, Friberg P, et al. Different relationships of spillover to release of norepinephrine in human heart, kidneys, and forearm. Am J Physiol 1998;275:R165-73.
16. Supiano MA, Hogikyan RV, Sidani MA, Galecki AT, Kruger J. Sympathetic nervous system activity and α-adrenergic responsiveness in older humans. Am J Physiol 1999;276:E519-28.
17. Starling MR. Effects of valve surgery on left ventricular contractile function in patients with long-term mitral regurgitation. Circulation 1995;92:811-8.
18. Vaz M, Jennings G, Turner A, et al. Regional sympathetic nervous activity and oxygen consumption in obese human subjects. Circulation 1997;96:3423-9.