The herbal medicine Unkei-to stimulates the secretion of a cytokine-induced neutrophil chemoattractant, CINC/gro, in the rat ovarian cell culture

American Journal of Reproductive Immunology

Volumn 49, Issue 1, 2003, Pages 14-20

  Yasui, Toshiyuki ^a   Matsuzaki, Toshiya ^a   Ogata, Rie ^a   Kiyokawa, Machiko ^a   Ushigoe, Kenjiro ^a   Uemura, Hirokazu ^a   Kuwahara, Akira ^a   Ikawa, Hiroshi ^a   Maegawa, Masahiko ^a   Furumoto, Hiroyuki ^a   Aono, Toshihiro ^a   Irahara, Minoru ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Cytokine induced neutrophil chemoattractant; Interleukin 1 ; Ovulation; Tumor necrosis factor ; Unkei to

Indexed keywords

CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; ESTRADIOL; HERBACEOUS AGENT; INTERLEUKIN 1BETA; PROGESTERONE; TOKISHAKUYAKU SAN; TUMOR NECROSIS FACTOR ALPHA; UNKEI TO;

ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DRUG CONCENTRATION; DRUG EFFECT; DRUG INDICATION; FEMALE; HERBAL MEDICINE; HORMONAL REGULATION; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IN VITRO STUDY; NONHUMAN; OVARY CELL CULTURE; OVARY INSUFFICIENCY; OVULATION; OVULATION INDUCTION; PRIORITY JOURNAL; RAT; STEROIDOGENESIS;

ANIMALS; CELL LINE; CHEMOKINES; CHEMOKINES, CXC; CHEMOTACTIC FACTORS; DRUGS, CHINESE HERBAL; ESTRADIOL; FEMALE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-1; NEUTROPHILS; OVARY; PROGESTERONE; RATS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0038274076     PISSN: 87558920     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0897.2003.01145.x     Document Type: Article

References (25)

1. Koyama T, Ohara M, Ichimura M, Saito M: Effect of Japanese kampo medicine on hypothalamic-pituitary-ovarian function in women with ovarian insufficiency. Am J Chin Med 1988; 16:47-55.
2. Yasui T, Aono T, Irahara M, Takahashi H, Yoshida J, Ino H, Sakamoto Y, Ikawa A, Takahashi H, Naka O, Sakaguchi A, Yoshimoto T, Kishi Y, Yamashita A, Kawano M, Takayanagi M, Kamada M, Maegawa M, Kamada T, Nagamachi N, Nakago K, Ihara M, Kuroiwa S, Okayama T, Takeuchi S, Miki S, Fujishima K: Studies on the combination treatment with Unkei-to and clomiphene citrate. Jpn J Fertil Steril 1990; 35:86-93.
3. Tamaya T, Ohno Y, Yamada T, Wada K, Fujimoto J, Okada H: Studies on traditional Chinese medicine (Kampo) in infertile or anovulatory women. Jpn J Fertil Steril 1982; 27:472-477.
4. Miyake A, Lee JW, Tasaka K, Ohtsuka S, Aono T: Wen-Jing-Tang, a traditional Chinese herbal medicine increases luteinizing hormone release in vitro. Am J Chin Med 1996; 14:157-160.
5. Aono T, Miyake A, Tanizawa O: Stimulatory effect of Unkei-to (TJ-106) on release of luteinizing hormone-releasing hormone and luteinizing hormone. In Recent Advances in the Pharmacology of Kampo (Japanese Herbal) Medicines, E Hosoya, Y Yamamura (eds). Tokyo, Excepta Medica, 1988, pp 191-196.
6. Taketani Y, Kugu K, Hayashi N, Mizuno M: Action of Unkei-to on cultured rat pituitary cells. In Recent Advances in the Pharmacology of Kampo (Japanese Herbal) Medicines, E Hosoya, Y. Yamamura (eds). Tokyo, Excepta Medica, 1988, pp 184-190.
7. Ushiroyama T, Tsubokura S, Ikeda A, Ueki M: The effect of Unkei-to on pituitary gonadotropin secretion and ovulation in anovulatory cycles of young women. Am J Chin Med 1995; 23:223-230.
8. Espey LL: Ovulation as an inflammatory reaction - A hypothesis. Biol Reprod 1988; 22:73-106.
9. Terranova PF, Montgomery RV: Cytokine involvement in ovarian processes. Am J Reprod Immunol 1997; 37:50-63.
10. Brannstrom M, Pascoe V, Norman RJ, McClure N: Localization of leukocyte subsets in the follicle wall and in the corpus luteum throughout the human menstrual cycle. Fertil Steril 1994; 61:488-495.
11. Brannstrom M, Mayrhofer G, Robertson SA: Localization of leukocyte subsets in the ovary during the periovulatory period. Biol Reprod 1993; 48:277-286.
12. Ushigoe K, Irahara M, Fukumochi M, Kamada M, Aono T: Production and regulation of cytokine-induced neutrophil chemoattractant in rat ovulation. Biol Reprod 2000; 63:121-126.
13. Irahara M, Yasui T, Tezuka M, Ushigoe K, Yamano S, Kamada M, Aono T: Evidence that Toki-Shakuyaku-san and its ingredients enhance the secretion of a cytokine-induced neutrophil chemoattractant (CINC/gro) in the ovulatory process. Meth Find Exp Clin Pharmacol 2000;22:725-730.
14. Magoffin DA, Erickson GF: Primary culture of differentiating ovarian androgen-producing cells in defined medium. J Biol Chem 1982; 257:4507-4513.
15. Ushiroyama T, Ikeda A, Sakai M, Hosotani T, Suzuki Y, Tsubokura S, Ueki M: Effects of Unkei-to, a herbal medicine, on endocrine function and ovulation in women with high basal levels of luteinizing hormone secretion. J Reprod Med 2001; 46:451-456.
16. Ota H, Tanaka H, Kodama H, Fukuda J, Karube H, Tanaka T: Effect of the kampo prescriptions on the secretion of interleukin-6 in human granulosa cells. Jpn J Fertil Steril 1996; 41:76-81.
17. Koike K, Zhang ZX, Sakamoto Y, Miyake A, Inoue M: Evidence that follicle-stellate cells mediate the inhibitory effect of Japanese kampo medicine, Unkei-to, on growth hormone secretion in rat anterior pituitary cell cultures. Am J Repro Immunol 1998; 39:217-222.
18. Usuki S: Effects of Hachimijiogan, Toki-shakuyaku-san and Keishibukuryogan, Ninjinto and Unkei-to on estrogen and progesterone secretion in preovulatory follicles incubated in vitro. Am J Chin Med 1991; 19:65-71.
19. Fujii T, Hamai Y, Kozuma S, Miki A, Yamashita A, Hyodo H, Unno N, Taketami Y: Effects of Sairei-to and Toki-shakuyaku-san on cytokine release from peripheral blood mononuclear cells upon recognition of HLA-G protein in the treatment of recurrent abortion. Meth Find Exp Clin Pharmacol 1999; 21:261-264.
20. Fujii T, Kanai T, Kozuma S, Hamai Y, Hyodo H, Yamashita T, Miki A, Unno N, Taketani Y: Theoretical basis for herbal medicines, Toki-shakuyaku-san and Sairei-to, in the treatment of autoimmunity-related recurrent abortion by correcting T helper-1/T helper-2 balance. Am J Repro Immun 2000; 44:342-346.
21. Takeda S, Isono T, Imai K, Ono E, Wakui Y, Sasaki H, Matsuzaki Y, Aburada M, Hosoya H: Pharmacokinetic study of several ingredients after oral dose of Toki-Shakuyaku-San in rats. Jpn Pharmacol Ther 1994; 22:249-254.
22. Ohtsuka T, Kubota A, Hirano T, Watanabe K, Yoshida H, Tsurufuji M, Iizuka Y, Konishi K, Tsurufuji S: Glucocorticoid-mediated gene suppression of rat cytokine-induced neutrophil chemoattractant CINC/gro, a member of the interleukin-8 family, through impairment of NF-kappa B activation. J Biol Chem 1996; 271:1651-1659.
23. Koike K, Zhang ZX, Sakamoto Y, Jikihara H, Masuhara K, Murakami K, Miyake A, Inoue M: The herbal medicine Unkei-to stimulates cytokine-induced neutrophil chemoattractant production in the pituitary folliculo-stellate-like cell line (TtT/GF). Am J Reprod Immunol 1998; 39:249-255.
24. Usuki S: Effects of Toki-shakuyaku-san and its components on rat corpus luteum function in vitro. Am J Chin Med 1988; 16:11-19.
25. Ota H, Tanaka H, Kodama H, Fukuda J, Karube H, Tanaka T: Effect of the kampo prescriptions and crude drugs on the steroidogenesis, particularly on aromatase activity in human granulosa cells. Jpn J Fertil Steril 1995; 40:355-361.