Theoretical basis for herbal medicines, Tokishakuyaku-San and Sairei-To, in the treatment of autoimmunity-related recurrent abortion by correcting T helper-1/T helper-2 balance

American Journal of Reproductive Immunology

Volumn 44, Issue 6, 2000, Pages 342-346

  Fujii, Tomoyuki ^a   Kanai, Takao ^a   Kozuma, Shiro ^a   Hamai, Yoko ^a   Hyodo, Hironobu ^a   Yamashita, Takahiro ^a   Miki, Akinori ^a   Unno, Nobuya ^a   Taketani, Yuji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Herbal medicine; Human leukocyte antigen G; Recurrent abortion; T helper 1 cytokine; T helper 2 cytokine

Indexed keywords

ALPHA INTERFERON; CYTOKINE; HLA G ANTIGEN; INTERLEUKIN 4; SAI; SAIREI TO; TOKI; TOKISHAKUYAKU SAN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; AUTOIMMUNITY; CELL LINE; CONTROLLED STUDY; CYTOKINE RELEASE; HELPER CELL; HERBAL MEDICINE; HUMAN; HUMAN CELL; MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RECURRENT ABORTION; THEORETICAL STUDY;

ABORTION, HABITUAL; ADULT; AUTOIMMUNITY; BENZOIC ACIDS; BRIDGED COMPOUNDS; CASPASE 1; CYTOKINES; DRUGS, CHINESE HERBAL; FEMALE; GLUCOSIDES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; INTERFERON TYPE II; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034534963     PISSN: 87558920     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.8755-8920.2000.440604.x     Document Type: Article

References (12)

1. Wegmann TG, Athanassakis I, Guilbert L, Branch D, Dy M, Menu E, Chaouat G: The role of M-CSF and GM-CSF in fostering placental growth, fetal growth, and fetal survival. Transpl Proc 1989; 21:566-568.
2. Hamai Y, Fujii T, Kozuma S, Shibata Y, Taketani Y: Secretion of interleukin-2 from imstimulated peripheral blood mononuclear cells is a possible pathogenic mechanism in recurrent abortion. Am J Reprod Immunol 1998; 40:63-64.
3. Lim KJ, Odukoya OA, Li TC, Cooke ID: Cytokines and immuno-endocrine factors in recurrent miscarriage. Hum Reprod Update 1996; 2:469-481.
4. Hill JA, Polger K, Anderson DJ: T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion. J Am Med Assoc 1995; 273:1933-1936.
5. Raghupathy R: Maternal anti-placental cell-mediated reactivity and spontaneous abortions. Am J Reprod Immunol 1997; 37:478-484.
6. Shaarawy M, Nagui AR: Enhanced expression of cytokines may play a fundamental role in the mechanisms of immunologically mediated recurrent spontaneous abortion. Acta Obstet Gynecol Scan 1997; 76:205-211.
7. Romagnani S: Th1 and Th2 in human diseases. Clin Immunol Immunopathol 1996; 80:225-235.
8. Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature 1996; 383:787-793.
9. Wegmann TG, Lin H, Guilbert L, Massmann TR: Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon? Immunol Today 1993; 14:353-356.
10. Hamai Y, Fujii T, Yamashita T, Miki A, Kozuma S, Geraghty DE, Taketani Y: Peripheral blood mononuclear cells from women with recurrent abortion exhibit an aberrant reaction to release cytokines upon the direct contact of human leukocyte antigen (HLA)-G expressing cells. Am J Reprod Immunol 1998; 40:408-413.
11. Chumbley G, King A, Robertson K, Holmes N, Loke YW: Resistance of HLA-G and HLA-A2 transfectants to lysis by decidual NK cells. Cell Immunol 1994; 155:312-322.
12. Miller AD, Miller DG, Garcia JV, Lynch CM: Use of retroviral vectors for gene transfer and expression. Methods Enzymol 1993; 217:581-599.