Heme-iron absorption is saturable by heme-iron dose in women

Journal of Nutrition

Volumn 133, Issue 7, 2003, Pages 2214-2217

  Pizarro, Fernando ^a   Olivares, Manuel ^a   Hertrampf, Eva ^a   Mazariegos, Dora Inés ^a   Arredondo, Miguel ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Heme iron absorption; Iron bioavailability; Iron forcification; Iron status

Indexed keywords

FERROUS SULFATE; HEME; HEMOGLOBIN; IRON; IRON 55; IRON 59;

ADULT; ARTICLE; BIOAVAILABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; GEOMETRY; HUMAN; INTESTINE ABSORPTION; IRON ABSORPTION; IRON INTAKE; MEAT; NORMAL HUMAN; QUANTITATIVE ANALYSIS; RABBIT;

ORYCTOLAGUS CUNICULUS;

EID: 0038267394     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.7.2214     Document Type: Article

References (30)

1. Bothwell, T. H., Charlton, R. W., Cook, J. D. & Finch, C. A. (1979) Iron metabolism in Man. Blackwell Scientific Publications, Oxford, UK.
2. Cook, J. D., Layrisse, M. & Finch, C. A. (1969) The measurement of ion absorption. Blood 33: 421-429.
3. Cook, J. D., Dassenko, S. A. & Lynch, S. R. (1991) Assessment of the role of non-heme iron availability in iron balance. Am. J. Clin. Nutr. 54: 717-722.
4. Layrisse, M., Cook, J. D., Martinez-Torres, C., Roche, M., Kuhn, I. N., Walker, R. B. & Finch, C. A. (1969) Food iron absorption: a comparison of vegetables and animal foods. Blood 33: 430-443.
5. Hallberg, L. & Bjorn-Rasmussen, E. (1972) Determination of iron absorption from the whole diet. A new two-pool model using two radioiron isotopes given as haem and non-haem iron. Scand. J. Haematol. 9: 193-197.
6. Conrad, M. E., Weintraub, L. R., Sears, D. A. & Crosby, W. H. (1966) Absorption of hemoglobin iron. Am. J. Physiol. 211: 1123-1130.
7. Raffin, S. B., Woo, C. H., Roost, K. T., Price, D. C. & Schmid, R. (1974) Intestinal absorption of hemoglobin heme iron cleavage by mucosal heme oxygenase. J. Clin. Invest. 54: 1344-1352.
8. Bothwell, T. H. (1983) Iron absorption. Ann. Rev. Med 34: 55-68.
9. Asenjo, J. A., Amar, M., Cartagena, N., King, J., Hiche, E. & Stekel, A. (1985) Use of a bovine heme iron concentrate in the fortification of biscuits. J. Food. Sci. 50: 795-799.
10. International Anemia Consultative Group (INACG). (1985) Measurement of Iron Status: A Report of the International Anemia Consultative Group, pp. 1-49. The Nutrition Foundation, Washington, DC.
11. Eakins, I. & Brown, D. (1966) An improved method for the simultaneous determinations of 55-iron and 59-iron in blood by liquid scintillation counting. Int. J. Appl. Radiat. Isotopes 17: 391-397.
12. Nadler, S. B., Hidalgo, I. V. & Block, T. (1962) The Tulane table of blood volume in normal men. Surgeon 51: 224-232.
13. Beard, J. L., Dawson, H. & Pinero, D. J. (1996) Iron metabolism: a comprehensive review. Nutr. Rev. 54: 295-317.
14. Roy, C. N. & Enns, C. A. (2000) Iron homeostasis: new tales from the crypt. Blood 96: 4020-4027.
15. Conrad, M. E. & Umbreit, J. N. (2000) Iron absorption and transport - an update. Am. J. Hematol. 64: 287-298.
16. Philpott, C. C. (2002) Molecular aspects of iron absorption: insights into the role of HFE in hemochromatosis. Hepatology 35: 993-1001.
17. Wyllie, J. C. & Kaufman, M. D. (1982) An electron microscopy study of heme uptake by rat duodenum. Lab. Invest. 47: 471-476.
18. Parmley, R. T., Barton, J. C., Conrad, M. E., Austin, R. L. & Holland, R. M. (1981) Ultraestructural cytochemistry and radioautography of hemoglobin-iron absorption. Exp. Mol. Pathol. 34: 131-134.
19. Grasbeck, R., Majuri, R., Kouvonen, I. & Tenhunen, R. (1982) Spectral and other studies on the intestinal haem receptor of the pig. Biochem. Biophys. Acta 700: 137-142.
20. Wheby, M. S., Jones, L. G. & Vrosby, W. H. (1964) Studies on iron absorption: intestinal regulatory mechanisms. J. Clin. Invest. 43: 1433-1442.
21. Weintraub, L. R., Weinstein, M. B., Huser, H. J. & Rafal, S. (1968) Absorption of hemoglobin iron: the role of a heme-splitting substance in the intestinal mucosa. J. Clin. Invest. 47: 531-539.
22. Wheby, M. S. & Spyker, D. A. (1981) Hemoglobin iron absorption kinetics in the iron-deficient dog. Am. J. Clin. Nutr. 34: 1686-1693.
23. Rosenberg, D. W. & Kappas, A. (1989) Characterization of heme oxygenase in the small intestinal epithelium. Arch. Biochem. Biophys. 274: 471-480.
24. Cable, J. W., Cable, E. E. & Bonkovsky, H. L. (1993) Induction of heme oxigenase in intestinal ephithelial cells: studies in caco-2 cell cultures. Mol. Cell. Biochem. 129: 93-98.
25. Boni, R. E., Hugh-Boni, R. A., Galbraith, R. A., Drummom, G. S. & Kappas, A. (1993) Tin-mesoporphyrin inhibits heme oxygenase activity and heme-iron absorption in the intestine. Pharmacology 47: 318-329.
26. Hallberg, L. & Solvell, L. (1967) Absorption of haemoglobin iron in man. Acta Med. Scand. 181: 335-355.
27. Bjorn-Rasmussen, E., Hallberg, L., Isaksson, B., Arridsson, B. (1974) Food iron absorption in man. Application of the two pool extrinsic tag method to measure haem and non-haem iron absorption from the whole diet. J. Clin. Invest. 53:247-255.
28. Turnbull, A., Cleton, F. & Finch C. A. (1962) Iron absorption. IV. The absorption of hemoglobin iron. J. Clin. Invest. 41: 1897-1907.
29. Young, G. P., Rose, I. S. & St John, D.J.B. (1989) Heme in the gut. I. Fate of hemeproteins and the absorption of heme. J. Gastroenterol. Hepatol. 4: 537-545.
30. Roberts, S. K., Henderson, R. W. & Young, G. P. (1993) Modulation of uptake of heme by rat small intestinal mucosa in iron deficiency. Am. J. Physiol. Gastrointest. Liver Physiol. 28: G712-G718.