Folate deficiency, homocysteine and dementia

Geriatrics and Aging

Volumn 6, Issue 4, 2003, Pages 24-28

  Gill, Sudeep S ^a   Alibhai, Shabbir M H ^b  

^a Kunin Lunenfeld Applied Research Unit and Department of Food and Nutrition Services and Baycrest Centre for Geriatric Care   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Deficiency diseases; Dementia; Folic acid; Homocysteine; Vitamin B12

Indexed keywords

AMINO ACID; CYANOCOBALAMIN; DIHYDROFOLATE REDUCTASE; DNA; FOLIC ACID; HOMOCYSTEINE; PTEROPTIN; PYRIDOXINE; S ADENOSYLMETHIONINE; TETRAHYDROFOLIC ACID; VITAMIN B GROUP;

AGED; AGING; ALCOHOL CONSUMPTION; AMINO ACID METABOLISM; BLOOD ANALYSIS; CHEILITIS; CHRONIC KIDNEY FAILURE; CLINICAL FEATURE; CLINICAL TRIAL; CYANOCOBALAMIN DEFICIENCY; DEMENTIA; DIETARY INTAKE; DNA SYNTHESIS; ELDERLY CARE; ENTEROPATHY; FATIGUE; FOLIC ACID DEFICIENCY; GENETIC DISORDER; HEART PALPITATION; HOMOCYSTINURIA; HORMONE ACTION; HUMAN; HYPERHOMOCYSTEINEMIA; HYPOTHYROIDISM; LABORATORY TEST; MEGALOBLASTIC ANEMIA; MENTAL DISEASE; NEURAL TUBE DEFECT; NEUROLOGIC DISEASE; NUTRITIONAL DISORDER; PALLOR; PATHOPHYSIOLOGY; REVIEW; STOMATITIS; SUPPLEMENTATION;

EID: 0038265261     PISSN: 14888408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Eikelboom JW, Lonn E, Genest J Jr, et al. Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence. Ann Intern Med 1999;131:363-75.
2. Joosten E, Lesaffre E, Riezler R, et al. Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? J Gerontol A Biol Sci Med Sci 1997;52:M76-9.
3. McCaddon A, Davies G, Hudson P, et al. Total serum homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psychiatry 1998;13:235-9.
4. McCaddon A, Hudson P, Davies G, et al. Homocysteine and cognitive decline in healthy elderly Dement Geriatr Cogn Disord 2001;12:309-13.
5. Clarke R, Smith AD, Jobst KA, et al. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55:1449-55.
6. Lehmann M, Gottfries CG, Regland B. Identification of cognitive impairment in the elderly: homocysteine is an early marker. Dement Geriatr Cogn Disord 1999;10:12-20.
7. Seshadri S, Beiser A, Selhus J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346:476-83.
8. Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician. Arch Intern Med 1999;159:1289-98.
9. Bailey LB. New standard for dietary folate intake in pregnant women. Am J Clin Nutr 2000;71:1304S-7S.
10. Tefferi A, Pruthi RK. The biochemical basis of cobalamin deficiency. Mayo Clin Proc 1994;69:181-6.
11. Martin DC. B12 and folate deficiency dementia. Clin Geriatr Med 1988;4: 841-52.
12. Reynolds EH. Folic acid, ageing, depression, and dementia. BMJ 2002;324:1512-5.
13. Hoffbrand V, Provan D. ABC of clinical hematology: macrocytic anemias. BMJ 1997;314:430-3.
14. McMillan SA, Haughton DJ, Biggart JD, et al. Predictive value for coeliac disease of antibodies to gliadin, endomysium, and jejunum in patients attending for jejunal biopsy. BMJ 1991;303:1163-5.
15. Rasmussen K, Moller J. Total homocysteine measurement in clinical practice. Ann Clin Biochem 2000;37:627-48.
16. Hankey GJ, Eikelboom JW. Homocysteine and vascular disease. Lancet 1999;354: 407-13.
17. Patterson CJ, Gauthier S, Bergman H, et al. The recognition, assessment and management of dementing disorders: conclusions from the Canadian Consensus Conference on Dementia. Can Med Assoc J 1999;160:1S-15S.
18. Knopman DS, DeKosky ST, Cummings JL, et al. Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001;56:1143-53.
19. Diaz-Arrastia R. Hyperhomocysteinemia: a new risk factor for Alzheimer disease? Arch Neurol 1998;55:1407-8.
20. Hussein WI, Green R, Jacobsen DK, et al. Normalization of hyperhomocysteinemia with L-thyroxine in hypothyroidism. Ann Intern Med 1999;131:348-51.
21. Selhub J, Jacques PF, Rosenberg IH, et al. Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med 1999;131:331-9.
22. Loscalzo J. Perspective: homocysteine and dementia. N Engl J Med 2002;346: 466-8.
23. Prins ND, Den Heijer T, Hofman A, et al. Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study Neurology 2002;59:1375-80.
24. Kalmijn S, Launer LJ, Lindemans J, et al. Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study. Am J Epidemiol 1999;150:293-9.
25. Schnyder G, Roffi M, Flammer Y, et al. Effect of homocysteine-lowering therapy with folic acid, vitamin B(12), and vitamin B(6) on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial. JAMA 2002;288: 973-9.
26. MacMahon M, Kirkpatrick C, Cummings CE, et al. A pilot study with simvastatin and folic acid/vitamin B12 in preparation for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH). Nutr Metab Cardiovasc Dis 2000;10:195-203.
27. Spence JD, Howard VJ, Chambless LE, et al. Vitamin Intervention for Stroke Prevention (VISP) trial: rationale and design. Neuroepidemiology 2001;20:16-25.
28. Willems HP, den Heijer M, Bos GM. Homocysteine and venous thrombosis: outline of a vitamin intervention trial. Semin Thromb Hemost 2000;26:297-304.
29. Stott D. Pilot study: trial of homocysteine reduction in the prevention of vascular events and dementia in the elderly (THRIVED). Cochrane Central Register of Controlled Trials. Accession Number CN-00342772.
30. Nilsson K, Gustafson L, Hultberg B. Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine. Int J Geriatr Psychiatry, 2001;16:609-14.