Modafinil maintains waking in the fruit fly Drosophila melanogaster

Sleep

Volumn 26, Issue 2, 2003, Pages 139-146

  Hendricks, Joan C ^a,c   Kirk, David ^a   Panckeri, Karen ^a   Miller, Matthew S ^b   Pack, Allan I ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CEPHALON INC   (United States)

^c Sleep Center   (United States)

Author keywords

Drosophila; Modafinil; Sleep like rest; State regulation; Wake promoting

Indexed keywords

MODAFINIL; BENZHYDRYL DERIVATIVE; CENTRAL STIMULANT AGENT;

AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG EFFECT; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; WAKEFULNESS; ANIMAL; DOSE RESPONSE; FEMALE; MALE;

ANIMALS; BENZHYDRYL COMPOUNDS; CENTRAL NERVOUS SYSTEM STIMULANTS; CIRCADIAN RHYTHM; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA MELANOGASTER; FEMALE; LOCOMOTION; MALE; WAKEFULNESS;

EID: 0038240433     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: 10.1093/sleep/26.2.139     Document Type: Article

References (23)

1. Hendricks JC, Finn SM, Panckeri KA et al. Rest in Drosophila is a sleep-like state Neuron 2000;25:129-38.
2. Shaw PJ, Cirelli C, Greenspan RJ, Tononi G. Correlates of sleep and waking in Drosophila melanogaster. Science 2000;287:1834-37.
3. Bastuji H, Jouvet M Treatment of hypersomnia with modafinil. Presse Medicale 1986;15:1330-1.
4. Edgar DM, Seidel WF. Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat. J Pharmacol Experimental Therapeutics 1997;283:757-69
5. Buguet A, Montmayeru A, Pigeau R, Naitoh P. Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. II Effects on two nights of recovery steep. J Sleep Res 1995;4:229-41.
6. Jasinski DR, Kovacevic-Ristanovic R. Evaluation of the abuse potential of modafinil and other drugs for treatment of excessive daytime sleepiness associated with narcolepsy Clin Neuropharmacol 2000;23:149-56.
7. Pigeau R, Naitoh P, Buguet A et al. Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature. J Sleep Res 1995;4:217-28.
8. Lin JS, Gervasoni D, Hou Y et al Effects of amphetamine and modafinil on the sleep/wake cycle during experimental hypersomnia induced by sleep deprivation in the cat. J Sleep Res 2000;9:89-96.
9. Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM Dopaminergic role in modafinil-induced wakefulness. J Neurosci 2001;21:1787-94.
10. Lin JS, Roussel B, Akaoka H, Fort P, BDebilly G, Jouvet M. Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat. Brain Res 1992;591:319-26.
11. Ferraro L, Antonelli T, O'Connor WT, Tanganelli S, Rambert FA, Fuxe K. Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers. Biol Psychiatry 1997;42:1181-3.
12. Lin JS, Hou Y, Jouvet M. Potential brain neuronal targets from amphetamine-, methylphenidate-, and modafinil-induced wakefulness evidenced by c-fos immunocytochemistry in the cat. Proc Natl Acad Sci, USA 1996;93:14128-33.
13. Scammell TE, Estaabrooke IV, McCarthy MT et al. Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci 2000;20:8620-8.
14. Wong YN, Simcoe D, Hartman LN et al. A double-blind, placebo-controlled, ascending dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers. J Clin Pharmacol 1999;39:30-40.
15. Hendricks JC, Williams JA, Pancken K, Kirk D, Yin JC-P, Sehgal A. A non-circadian role for CAMP signaling and CREB activity in waking and rest homeostasis in Drosophila melanogaster. Nature Neurosci 2001;4:1108-15.
16. Brun J, Chamba G, Khalfallah Y et al. Effect of modafinil on plasma melatonin, cortisol and growth hormone rhythms, rectal temperature and performance in healthy subjects during a 36 h sleep deprivation. J Sleep Res 1998;7:105-14.
17. Kopp C, Petit J-M, Magistretti P, Borbely AA and Tobler I. Comparison of the effects of modafinil and sleep deprivation on sleep and cortical EEG spectra in mice. Neuropharmacology, 43:110-118, 2002.
18. Sarov-Blat L, So W, Liu L, Rosbash M. The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior. Cell 2000;101:647-656
19. Hermant JF, Rambert FA, Duteil J. Awakening properties of modafinil. effect on nocturnal activity in monkeys (Macaca mulatta) after acute and repeated administration. Psychopharmacology 1991;103:28-32
20. Baranski JV, Pigeau RA Self-monitoring cognitive performance during sleep deprivation effects of modafinil, d-amphetamine and placebo. J Sleep Res 1997;6:84-91.
21. Sebhan C, Tesolin-Decros B, Millan MJ, Spedding M. Contrasting EEG profiles elicited by antipsychotic agents in the prefrontal cortex of the conscious rat: antagonism of the effects of clozapine by modafinil Brit J Pharmacol 1999;128:1055-63.
22. Rubin GM, Yandell MD, Wortman JR. Comparative genomics of the eukaryotes. Science 2000;287:2204-2215.
23. Walker RJ, Brooks HL, Holden-Dye L. Evolution and overview of classical transmitter molecules and their receptors. Parasitology 1996;113:Suppl:S3-33.