Molecular dynamics, free energy, and SPR analyses of the interactions between the SH2 domain of Grb2 and ErbB phosphotyrosyl peptides

Biochemistry

Volumn 42, Issue 18, 2003, Pages 5195-5200

  Suenaga, Atsushi ^a   Hatakeyama, Mariko ^a   Ichikawa, Mio ^a   Yu, Xiaomei ^a   Futatsugi, Noriyuki ^a   Narumi, Tetsu ^a   Fukui, Kazuhiko ^b   Terada, Takaho ^a   Taiji, Makoto ^a   Shirouzu, Mikako ^a   Yokoyama, Shigeyuki ^a,c,d   Konagaya, Akihiko ^a  

^a RIKEN YOKOHAMA INSTITUTE   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c RIKEN HARIMA INSTITUTE   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; FREE ENERGY; MOLECULAR DYNAMICS; SURFACE PLASMON RESONANCE; VAN DER WAALS FORCES;

BINDING AFFINITY;

PROTEINS;

ALANYLGLYCYLSERYLVALYLGLUTAMINYLASPARAGINYLPROLYLVALYLPHOSPHOTYROSYLHISTIDY LASPARAGINYLGLUTAMINYLPROLYLLEUCYLASPARAGINYLPROLYLALANYLPROLINE; ASPARTYLASPARTYLVALYLVALYLASPARTYLALANYLASPARTYLGLUTAMYLPHOSPHOTYROSYLLEUCY LISOLEUCYLPROLYLGLUTAMINYLGLUTAMINYLGLYCYLPHENYLALANYLPHENYLALANYLPHENYLALANYLSE RINE; ASPARTYLTHREONYLPHENYLALANYLLEUCYLPROLYLVALYLPROLYLGLUTAMYLPHOSPHOTYROSYLIS OLEUCYLASPARAGINYLGLUTAMINYLSERYLVALYLPROLYLLYSYLARGININE; GLUTAMINYLISOLEUCYLSERYLLEUCYLASPARTYLASPARAGINYLPROLYLASPARTYLPHOSPHOTYROS YLGLUTAMINYLGLUTAMINYLASPARTYLPHENYLALANYLPHENYLALANYLPROLYLLYSYLGLUTAMYLALANYLL YSINE; GLYCYLSERYLTHREONYLALANYLGLUTAMYLASPARAGINYLALANYLGLUTAMYLPHOSPHOTYROSYLLEU CYLARGINYLVALYLALANYLPROLYLGLUTAMINYLSERYLSERYLGLUTAMIC ACID; GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HISTIDYLSERYLPROLYLPROLYLPROLYLALANYLPHOSPHOTYROSYLPROLYLMETHIONYLSERYLGLYC YLASPARAGINYLGLUTAMINE; LYSYLASPARAGINYLGLYCYLASPARTYLLEUCYLGLUTAMINYLALANYLLEUCYLASPARTYLASPARAGIN YLPROLYLGLUTAMYLPHOSPHOTYROSYLHISTIDYLASPARAGINYLALANYLSERYLASPARAGINYLGLYCYLPRO LINE; LYSYLGLUTAMYLASPARTYLSERYLPHENYLALANYLLEUCYLGLUTAMINYLARGINYLPHOSPHOTYROSYL SERYLSERYLASPARTYLPROLYLTHREONYLGLYCYLALANINE; PEPTIDE; PHOSPHOTYROSYL PEPTIDE; PROLYLGLUTAMYLLYSYLALANYLLYSYLLYSYLALANYLPHENYLALANYLASPARTYLASPARAGINYLPRO LYLASPARTYLPHOSPHOTYROSYLTRYPTOPHYLASPARAGINYLHISTIDYLSERYLLEUCYLPROLYLPROLINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CORRELATION COEFFICIENT; ENERGY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; SURFACE PLASMON RESONANCE; TECHNIQUE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; COMPUTER SIMULATION; GLUTATHIONE TRANSFERASE; GRB2 ADAPTOR PROTEIN; HUMANS; KINETICS; LIGANDS; PEPTIDE FRAGMENTS; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; SRC HOMOLOGY DOMAINS; THERMODYNAMICS; TYROSINE;

UNIDENTIFIED AGENTS;

EID: 0038219754     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034113h     Document Type: Article

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