Involvement of N-methyl-D-aspartate receptors in post-hypoxic depression of the dorsomedial medulla in cats

Neuroscience Letters

Volumn 343, Issue 3, 2003, Pages 190-194

  Hong, Ling Zong ^a   Chai, Chok Yung ^b  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Hypoxia; Medulla; N Methyl D aspartate; Pressor response; Sympathoexcitatory response

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; GLUTAMATE RECEPTOR AGONIST; KYNURENIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; N METHYLASPARTIC ACID;

ARTERIAL PRESSURE; ARTICLE; BLOOD GAS; CAT; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HEART RATE; HYPOXIA; MALE; MEAN ARTERIAL PRESSURE; MEDULLA OBLONGATA; NERVE EXCITABILITY; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; ANIMAL; ANOXIA; BLOOD GAS ANALYSIS; BLOOD PRESSURE; CHEMICAL PHENOMENA; DOSE RESPONSE; DRUG EFFECT; MICROINJECTION; PATHOPHYSIOLOGY; PHYSIOLOGY; SPINAL NERVE;

2-AMINO-5-PHOSPHONOVALERATE; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANOXIA; BLOOD GAS ANALYSIS; BLOOD PRESSURE; CATS; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HEART RATE; KYNURENIC ACID; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; N-METHYLASPARTATE; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL NERVES;

EID: 0038209655     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(03)00400-2     Document Type: Article

References (15)

1. Goodchild A.K., Dampney R.A. A vasopressor cell group in the rostral dorsomedial medulla of the rabbit. Brain Res. 360:1985;24-32.
2. Gozal D., Xue Y.D., Simakajornboon N. Hypoxia induces c-Fos protein expression in NMDA but not AMPA glutamate receptor labeled neurons within the nucleus tractus solitarii of the conscious rat. Neurosci. Lett. 262:1999;93-96.
3. Hirooka Y., Polson J.W., Dampney R.A. Pressor response from rostral dorsomedial medulla is mediated by excitatory amino acid receptors in rostral VLM. Am. J. Physiol. 267:1994;R309-R315.
4. Hong L.Z., Kuo J.S., Yen M.H., Chai C.Y. Dorsomedial medulla is more susceptible than rostral ventrolateral medulla to hypoxic insult in cats. J. Appl. Physiol. 90:2001;248-260.
5. Hoop B., Masjedi M.R., Shih V.E., Kazemi H. Brain glutamate metabolism during hypoxia and peripheral chemodenervation. J. Appl. Physiol. 69:1990;147-154.
6. Kogan J.H., Aghajanian G.K. Long-term glutamate desensitization in locus coeruleus neurons and its role in opiate withdrawal. Brain Res. 689:1995;111-121.
7. Krnjevic K. Anoxia and NMDA receptors. Adv. Exp. Med. Biol. 268:1990;475-479.
8. Martin R.L., Lloyd H.G., Cowan A.I. The early events of oxygen and glucose deprivation: setting the scene for neuronal death? Trends Neurosci. 17:1994;251-257.
9. Mironov S.L., Richter D.W. L-Type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J. Physiol. Lond. 512:1998;75-87.
10. Miyawaki T., Minson J., Arnolda L., Llewellyn Smith I., Chalmers J., Pilowsky P. AMPA/kainate receptors mediate sympathetic chemoreceptor reflex in the rostral ventrolateral medulla. Brain Res. 726:1996;64-68.
11. Rothman S.M., Olney J.W. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann. Neurol. 19:1986;105-111.
12. Su C.K., Lin A.M., Lin R.H., Kuo J.S., Chai C.Y. Contribution between dorsal and ventrolateral regions of medulla oblongata in vasomotor function of cats. Brain Res. Bull. 23:1989;447-456.
13. Sun M.K., Reis D.J. Central neural mechanisms mediating excitation of sympathetic neurons by hypoxia. Prog. Neurobiol. 44:1994;197-219.
14. Sun M.K., Reis D.J. NMDA receptor-mediated sympathetic chemoreflex excitation of RVL- spinal vasomotor neurones in rats. J. Physiol. Lond. 482:1995;53-68.
15. Tsuchihashi T., Liu Y., Kagiyama S., Matsumura K., Abe I., Fujishima M. Metabotropic glutamate receptor subtypes involved in cardiovascular regulation in the rostral ventrolateral medulla of rats. Brain Res. Bull. 52:2000;279-283.