Hypoxia induces c-Fos protein expression in NMDA but not AMPA glutamate receptor labeled neurons within the nucleus tractus solitarii of the conscious rat

Neuroscience Letters

Volumn 262, Issue 2, 1999, Pages 93-96

  Gozal, David ^a,b   Xue, Ying Dan ^a   Simakajornboon, Narong ^a  

^a Section of Pediatric Pulmonology Critical Care and Allergy   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate; Cardiovascular regulation; Control of breathing; Glutamate receptors; Hypoxia; N Methyl D aspartate

Indexed keywords

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR; DIZOCILPINE; GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR AUTOREGULATION; CONTROLLED STUDY; HYPOXIA; MALE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; RESPIRATION CONTROL; SOLITARY TRACT NUCLEUS;

AIR; AMINO ACID SEQUENCE; ANIMALS; CELL HYPOXIA; CONSCIOUSNESS; DIZOCILPINE MALEATE; GENE EXPRESSION REGULATION; MALE; MOLECULAR SEQUENCE DATA; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SOLITARY NUCLEUS;

EID: 0033525918     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00065-8     Document Type: Article

References (21)

1. Brew, S., DeCastro, D., Housley, G. D. and Sinclair, J.D., The role of glutamate in the transmission of the hypoxic input to respiration through the nucleus of the tractus solitarius. In H. Acker, A. Trzebki, R.G. O'Rega (Eds.), Chemoreceptors and Chemoreceptor Reflexes, Plenum Press, New York, 1990, pp. 331-338.
2. Chan J.Y., Yang S.M., Chan S.H. Mediation by N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors in the expression of Fos protein at the nucleus tractus solitarii in response to baroreceptor activation in the rat. Neuroscience. 83:1998;93-105.
3. Erickson J.T., Millhorn D.E. Hypoxia and electrical stimulation of the carotid sinus nerve induce Fos-like immunoreactivity within catecholaminergic and serotoninergic neurons of the rat brainstem. J. Comp. Neurol. 348:1994;161-182.
4. Finley J.C.W., Katz D.M. The central organization of carotid body afferent projections to the brainstem of the rat. Brain Res. 572:1992;108-116.
5. Haxhiu M.A., Strohl K.P., Cherniack N.S. The N-methyl-D-aspartate receptor pathway is involved in hypoxia-induced c-Fos protein expression in the rat nucleus of the solitary tract. J. Auton. Nerv. Syst. 55:1995;65-68.
6. Housley G.D., Sinclair J.D. Localization of kainic acid lesions of neurons transmitting the carotid chemoreceptor stimulus for respiration in the rat. J. Physiol. (London). 406:1988;99-114.
7. Jordan D., Spyer K.M. Brainstem integration of cardiovascular and pulmonary afferent activity. Prog. Brain Res. 67:1986;295-314.
8. LeGadoullec E., Merahi N., Laguzzi R. Cardiovascular changes induced by the local application of glutamate-related drugs in the rat nucleus tractus solitarii. Brain Res. 503:1989;322-325.
9. Martin L.J., Blackstone C.D., Levey A.I., Huganir R.L., Price D.L. AMPA glutamate receptor subunits are differentially distributed in rat brain. Neuroscience. 53:1993;327-358.
10. Mizusawa A., Ogawa H., Kikuchi Y., Hida W., Kurosawa H., Okabe S., Takishima T., Shirato K. In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia. J. Physiol. (Lond.). 478:1994;55-65.
11. Morgan J.I., Curran T. Role of ion flux in the control of c-fos expression. Nature. 322:1986;552-555.
12. Ohta H., Talman W.T. Both NMDA and non-NMDA receptors in the NTS participate in the baroreceptor reflex in rats. Am. J. Physiol. 267:1994;R1065-R1070.
13. Ohtake P.J., Torres J.E., Gozal Y.M., Graff G.R., Gozal D. NMDA receptors mediate cardiorespiratory responses to afferent peripheral chemoreceptor input in the conscious rat. J. Appl. Physiol. 84:1998;853-861.
14. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press, New York, 1986.
15. Petralia R.S., Yokotani N., Wenthold R.J. Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody. J. Neurosci. 14:1994;667-696.
16. Soto-Arape I., Burton M.D., Kazemi H. Central amino acid neurotransmitters and the hypoxic ventilatory response. Am. J. Resp. Crit. Care Med. 151:1995;1113-1120.
17. Talman W.T., Perrone M.H., Reis D.J. Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers. Science. 209:1980;813-815.
18. Teppema L.J., Veening J.G., Kranenburg A., Dahan A., Berkenbosch A., Olievier C. Expression of c-fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia. J. Comp. Neurol. 388:1997;169-190.
19. Vardhan A., Kachroo A., Sapru H.N. Excitatory aminoacid receptors in comissural nucleus of the NTS mediate carotid chemoreceptor responses. Am. J. Physiol. 264:1993;R41-R50.
20. Wenthold R.J., Yokotani N., Doi K., Wada K. Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies: evidence for a hetero-oligomeric structure in rat brain. J. Biol. Chem. 267:1992;501-507.
21. Zhou Z., Champagnat J., Poon C.S. Phasic and long-term depression in brainstem nucleus tractus solitarius neurons: differing roles of AMPA receptor desensitization. J. Neurosci. 17:1997;5349-5356.