Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin

Annals of Anatomy

Volumn 185, Issue 3, 2003, Pages 233-238

  Haninec, Pavel ^a   Houšt'ava, Ladislav ^a   Stejskal, Lubomír ^a   Dubový, Petr ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Apoptosis; Neuron supporting effects; Neurotrophic

Indexed keywords

CEREBROLYSIN; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AVULSION INJURY; CELL DEATH; CELL LOSS; CELL SURVIVAL; CERVICAL SPINAL CORD; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL MODEL; FEMALE; NONHUMAN; RAT; SPINAL CORD MOTONEURON; SPINAL CORD VENTRAL HORN; TREATMENT OUTCOME; VENTRAL ROOT;

ANIMALIA;

EID: 0038203257     PISSN: 09409602     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-9602(03)80030-4     Document Type: Article

References (27)

1. Bertelli JA, Mira JC (1993) Behavioral evaluating methods in the objective clinical assessment of motor function after experimental brachial plexus reconstruction in the rat. J Neurosci Meth 46: 203-208
2. Bertelli JA, Mira JC (1994) Brachial plexus repair by peripheral nerve grafts directly into the spinal cord in rats. J Neurosurg 81: 107-114
3. Butt AJ, Firth SM, Baxter RC (1999) The IGF axis and programmed cell death. Immunol Cell Biol 77: 256-262
4. Carlstedt T, Linda H, Cullheim S, Risling M (1986) Reinnervation of hind limb muscles after ventral root avulsion and implantation in the lumbar spinal cord. Acta Physiol Scand 128: 645-646
5. Carlstedt T, Grane P, Hallin RG, Norén G (1995) Return of function after spinal cord implantation of avulsed spinal nerve roots. Lancet 346: 1323-1325
6. Cruz R, Francis L, Diaz-Suarez CM, Gonzalez-Fraguela ME (1998) Short-term effects of septo-hippocampal pathway transsection and cerebrolysin effects on glutathione-related enzymes in the rat brain. Rev Neurol 26: 551-554
7. Cullheim S, Carlstedt T, Linda H, Risling M, Ulfhake B (1989) Motoneurons reinnervate skeletal muscle after ventral root implantation into the spinal cord of the cat. Neuroscience 29: 725-733
8. Hallin RG, Carlstedt T, Nilsson-Remahl I, Risling M (1999) Spinal cord implantation of avulsed ventral roots in primates; correlation between restored motor function and morphology. Exp Brain Res 124: 304-310
9. Haninec P, Dubovy P, Houšt'ava L, Stejskal L (1996) Alternative methods of the brachial plexus reconstruction - An experimental study. Scripta Med 69: 221-226
10. Haninec P, Dubovy P, Houšt'ava L, Stejskal L (1997) Reconstructive operations of brachial plexus injury and the experimental model of their management. In: 11th Intern Congr Neurol Surg, Amsterdam 1997. Monduzzi Editore, Bologna, pp 2103-2107
11. Haninec P, Dubovy P, Houšt'ava L, Stejskal L (1998) Surgical management of brachial plexus injuries and the experimental reinnervation of the biceps brachii muscle by the spinal motor neurons through acellular nerve graft. In: Roth JH, Richards RS (eds) 7th Congr. IFSSH, Vancouver 1998. Monduzzi Editore, Bologna, pp 77-80
12. Haninec P, Dubovy P, Houšt'ava L, Stejskal L (2000) Acellular nerve graft re-seeded by Schwann cells migrating from the nerve stump can stimulate spinal motoneurons for functional reinnervation of the rat muscle. Anat Anz 182: 123-131
13. Horvat JC, Pecot-Deachavassine M, Mira JC (1988) Functional reinnervation of a denervated skeletal muscle of the adult rat by axons regenerating from the spinal cord through a peripheral nervous system graft. Progr Brain Res 78: 219-224
14. Hughes RA, Sendtner M, Thoenen H (1993) Members of several gene families influence survival of rat motoneurons in vitro and in vivo. J Neurosci Res 36: 663-671
15. Koliatsos VE, Price WL, Pard CA, Price DL (1994) Ventral root avulsion - an experimental model of death of adult motor neurons. J Comp Neurol 324: 35-44
16. Li LX, Wu WT, Lin LFH, Lei M, Oppenheim RW, Houenou LJ (1995) Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor. Proc Natl Acad Sci USA 92: 9771-9775
17. Moissonnier P, Reviron T, Ye JH, Horvat JC (1996) Motoneurons of the injured spinal cord of the adult dog can grow lengthy axons into an autologous peripheral nerve graft. A retrograde axonal tracing study. Spinal Cord 34: 320-325
18. Neff NT, Prevette D, Hounnenou LJ, Lewis ME, Glicksman MA, Yin QW, Oppenheim RW (1993) Insulin-like growth factors: putative muscle-derived trophic agents that promote motoneuron survival. J Neurobiol 24: 1578-1588
19. Novikov L, Novikova L, Kellerth JO (1995) Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral root avulsion. Neurosci Lett 200: 45-48
20. Oorschot DE, McLennan IS (1998) The trophic requirements of mature motoneurons. Brain Res 789: 315-321
21. Oppenheim RW, Prevette D, Haverkamp LJ, Houenou L, Yin QW, McManaman J (1993) Biological studies of a putative avian muscle-derived neurotrophic factor that prevents naturally occurring motoneuron death in vivo. J Neurobiol 24: 1065-1079
22. Oppenheim RW (1996) Neurotrophic survival molecules for motoneurons: An embarrassment of riches. Neuron 17: 195-197
23. Sugita Y, Kondo T, Kanazawa A, Itou T, Mizuno Y (1993) Protective effect of FPF 1070 (cerebrolysin) on delayed neuronal death in the gerbil - detection of hydroxyl radicals with salicylic acid. No To Shinkei 45: 325-331
24. Vergani L, Di Giulio AM, Losa M, Rossoni G, Muller EE, Gorio A (1998) Systemic administration of insulin-like growth factor decreases motor neuron cell death and promotes muscle reinnervation. J Neurosci Res 54: 840-847
25. Wu W (1993) Expression of nitric-oxide synthase (NOS) in injured CNS neurons as shown by NADPH diaphorase histochemistry. Exp Neurol 120: 153-159
26. Yan Q, Elliott JL, Matheson C, Sun J, Zhang L, Mu X, Rex KL, Snider WD (1993) Influences of neurotrophins on mammalian motoneurons in vivo. J Neurobiol 24: 1555-1577
27. Zamboni L, DeMartino C (1967) Buffered picric acid-formaldehyde: a new, rapid fixative for electron microscopy. J Cell Biol 35: 14