Dynamic combinatorial optimization of a neutral receptor that binds inorganic anions in aqueous solution

Journal of the American Chemical Society

Volumn 125, Issue 26, 2003, Pages 7804-7805

  Otto, Sijbren ^a   Kubik, Stefan ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANION; CYCLOPEPTIDE; HALIDE; HEXAPEPTIDE; SULFATE;

AQUEOUS SOLUTION; ARTICLE; COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; COMPLEX FORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RECEPTOR BINDING; THERMODYNAMICS;

EID: 0038203167     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0351589     Document Type: Article

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21. 4 is rather erratic, however, and more reproducible results are obtained with KI.
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23. For reviews on anion receptors, see: (a) Schmidtchen, F. P.; Berger, M. Chem. Rev. 1997, 97, 1609-1646. (b) Antonisse, M. M. G.; Reinhoudt, D. N. Chem. Commun. 1998, 443-448. (c) Snowden, T. S.; Anslyn, E. V. Curr. Opin. Chem. Biol. 1999, 3, 740-746. (d) Beer, P. D.; Gale, P. A. Angew. Chem., Int. Ed. 2001, 40, 486-516. For studies on neutral synthetic anion receptors in aqueous mixtures see: (e) Fan, E.; Van Arman, S. A.; Kincaid, S.; Hamilton, A. D. J. Am. Chem. Soc. 1993, 115, 369-370. (f) Jagessar, R. C.; Shang, M.; Scheidt, W. R.; Burns, D. H. J. Am. Chem. Soc. 1998, 120, 11684-11692. (g) Anzenbacher, P., Jr.; Jursíková, K.; Sessler, J. L. J. Am. Chem. Soc. 2000, 122, 9350-9351.
24. For reviews on anion receptors, see: (a) Schmidtchen, F. P.; Berger, M. Chem. Rev. 1997, 97, 1609-1646. (b) Antonisse, M. M. G.; Reinhoudt, D. N. Chem. Commun. 1998, 443-448. (c) Snowden, T. S.; Anslyn, E. V. Curr. Opin. Chem. Biol. 1999, 3, 740-746. (d) Beer, P. D.; Gale, P. A. Angew. Chem., Int. Ed. 2001, 40, 486-516. For studies on neutral synthetic anion receptors in aqueous mixtures see: (e) Fan, E.; Van Arman, S. A.; Kincaid, S.; Hamilton, A. D. J. Am. Chem. Soc. 1993, 115, 369-370. (f) Jagessar, R. C.; Shang, M.; Scheidt, W. R.; Burns, D. H. J. Am. Chem. Soc. 1998, 120, 11684-11692. (g) Anzenbacher, P., Jr.; Jursíková, K.; Sessler, J. L. J. Am. Chem. Soc. 2000, 122, 9350-9351.
25. For reviews on anion receptors, see: (a) Schmidtchen, F. P.; Berger, M. Chem. Rev. 1997, 97, 1609-1646. (b) Antonisse, M. M. G.; Reinhoudt, D. N. Chem. Commun. 1998, 443-448. (c) Snowden, T. S.; Anslyn, E. V. Curr. Opin. Chem. Biol. 1999, 3, 740-746. (d) Beer, P. D.; Gale, P. A. Angew. Chem., Int. Ed. 2001, 40, 486-516. For studies on neutral synthetic anion receptors in aqueous mixtures see: (e) Fan, E.; Van Arman, S. A.; Kincaid, S.; Hamilton, A. D. J. Am. Chem. Soc. 1993, 115, 369-370. (f) Jagessar, R. C.; Shang, M.; Scheidt, W. R.; Burns, D. H. J. Am. Chem. Soc. 1998, 120, 11684-11692. (g) Anzenbacher, P., Jr.; Jursíková, K.; Sessler, J. L. J. Am. Chem. Soc. 2000, 122, 9350-9351.
26. For reviews on anion receptors, see: (a) Schmidtchen, F. P.; Berger, M. Chem. Rev. 1997, 97, 1609-1646. (b) Antonisse, M. M. G.; Reinhoudt, D. N. Chem. Commun. 1998, 443-448. (c) Snowden, T. S.; Anslyn, E. V. Curr. Opin. Chem. Biol. 1999, 3, 740-746. (d) Beer, P. D.; Gale, P. A. Angew. Chem., Int. Ed. 2001, 40, 486-516. For studies on neutral synthetic anion receptors in aqueous mixtures see: (e) Fan, E.; Van Arman, S. A.; Kincaid, S.; Hamilton, A. D. J. Am. Chem. Soc. 1993, 115, 369-370. (f) Jagessar, R. C.; Shang, M.; Scheidt, W. R.; Burns, D. H. J. Am. Chem. Soc. 1998, 120, 11684-11692. (g) Anzenbacher, P., Jr.; Jursíková, K.; Sessler, J. L. J. Am. Chem. Soc. 2000, 122, 9350-9351.
27. For reviews on anion receptors, see: (a) Schmidtchen, F. P.; Berger, M. Chem. Rev. 1997, 97, 1609-1646. (b) Antonisse, M. M. G.; Reinhoudt, D. N. Chem. Commun. 1998, 443-448. (c) Snowden, T. S.; Anslyn, E. V. Curr. Opin. Chem. Biol. 1999, 3, 740-746. (d) Beer, P. D.; Gale, P. A. Angew. Chem., Int. Ed. 2001, 40, 486-516. For studies on neutral synthetic anion receptors in aqueous mixtures see: (e) Fan, E.; Van Arman, S. A.; Kincaid, S.; Hamilton, A. D. J. Am. Chem. Soc. 1993, 115, 369-370. (f) Jagessar, R. C.; Shang, M.; Scheidt, W. R.; Burns, D. H. J. Am. Chem. Soc. 1998, 120, 11684-11692. (g) Anzenbacher, P., Jr.; Jursíková, K.; Sessler, J. L. J. Am. Chem. Soc. 2000, 122, 9350-9351.
28. For reviews on anion receptors, see: (a) Schmidtchen, F. P.; Berger, M. Chem. Rev. 1997, 97, 1609-1646. (b) Antonisse, M. M. G.; Reinhoudt, D. N. Chem. Commun. 1998, 443-448. (c) Snowden, T. S.; Anslyn, E. V. Curr. Opin. Chem. Biol. 1999, 3, 740-746. (d) Beer, P. D.; Gale, P. A. Angew. Chem., Int. Ed. 2001, 40, 486-516. For studies on neutral synthetic anion receptors in aqueous mixtures see: (e) Fan, E.; Van Arman, S. A.; Kincaid, S.; Hamilton, A. D. J. Am. Chem. Soc. 1993, 115, 369-370. (f) Jagessar, R. C.; Shang, M.; Scheidt, W. R.; Burns, D. H. J. Am. Chem. Soc. 1998, 120, 11684-11692. (g) Anzenbacher, P., Jr.; Jursíková, K.; Sessler, J. L. J. Am. Chem. Soc. 2000, 122, 9350-9351.