Perturbations in the thiol homeostasis following neonatal cerebral hypoxia-ischemia in rats

Neuroscience Letters

Volumn 345, Issue 1, 2003, Pages 65-68

  Dafre, Alcir Luiz ^a   Arteni, Nice S ^b   Siqueira, Ionara R ^b   Netto, Carlos Alexandre ^b  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Glutathione; Glutathione disulphide; Hypoxia ischemia; Newborn rats; Protein mixed disulphide; Protein thiols; S Thiolation

Indexed keywords

DISULFIDE; GLUTATHIONE; GLUTATHIONE DISULFIDE; PROTEIN DERIVATIVE; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN LEVEL; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; HIPPOCAMPUS; HOMEOSTASIS; MALE; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

EID: 0038180777     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(03)00510-X     Document Type: Article

References (24)

1. Akerboom T.P.M., Sies H. Assay of glutathione, glutathione disulphide, and glutathione mixed disulphides in biological samples. Methods Enzymol. 77:1981;373-382.
2. Aksenov M.Y., Markesbery W.R. Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer's disease. Neurosci. Lett. 302:2001;141-145.
3. Bharath S., Hsu M., Kaur D., Rajagopalan S., Andersen J. Glutathione, iron and Parkinson's disease. Biochem. Pharmacol. 64:2002;1037-1048.
4. Brigelius R., Muckel C., Akerboom T.P.M., Sies H. Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide. Biochem. Pharmacol. 32:1983;2529-2534.
5. Cooper A.J., Pulsinelli W.A., Duffy T.E. Glutathione and ascorbate during ischemia and postischemic reperfusion in rat brain. J. Neurochem. 35:1980;1242-1245.
6. Cooper A.J. Role of astrocytes in maintaining cerebral glutathione homeostasis and in protecting the brain against xenobiotics and oxidative stress. Shaw C.A. Glutathione in the Nervous System. 1998;91-115 Taylor and Francis, Bristol.
7. Dringen R. Metabolism and functions of glutathione in brain. Prog. Neurobiol. 62:2000;649-671.
8. Dringen R., Kranich O., Hamprecht B. The gamma-glutamyl transpeptidase inhibitor acivicin preserves glutathione released by astroglial cells in culture. Neurochem. Res. 22:1997;727-733.
9. Eaton D.L., Bammler T.K. Concise review of the glutathione S-transferases and their significance to toxicology. Toxicol. Sci. 49:1999;156-164.
10. Jocelyn P.C. Spectrophotometric assay of thiols. Methods Enzymol. 143:1987;44-67.
11. Klatt P., Lamas S. Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress. Eur. J. Biochem. 267:2000;4928-4944.
12. Kohr G., Eckardt S., Luddens H., Monyer H., Seeburg P.H. NMDA receptor channels: subunit-specific potentiation by reducing agents. Neuron. 12:1994;1031-1040.
13. Murphy T.H., Schnaar R.L., Coyle J.T. Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. FASEB J. 4:1990;1624-1633.
14. Orwar O., Li X., Andine P., Bergstrom C.M., Hagberg H., Folestad S., Sandberg M. Increased intra- and extracellular concentrations of γ-glutamylglutamate and related dipeptides in the ischemic rat striatum: involvement of glutamyl transpeptidase. J. Neurochem. 63:1994;1371-1376.
15. Panigrahi M., Sadguna Y., Shivakumar B.R., Kolluri S.V., Roy S., Packer L., Ravindranath V. α-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 717:1996;184-188.
16. Ravindranath V., Shivakumar B.R., Anandatheerthavarada H.K. Low glutathione levels in brain regions of aged rats. Neurosci. Lett. 101:1989;187-190.
17. Sacchetta P., Di Cola D., Federici G. Alkaline hydrolysis of N-ethylmaleimide allows a rapid assay of glutathione disulfide in biological samples. Anal. Biochem. 154:1986;205-208.
18. Shaw C.A. Glutathione in the Nervous System. 1998;Taylor and Francis, Bristol.
19. Shivakumar B.R., Kolluri S.V., Ravindranath V. Glutathione and protein thiol homeostasis in brain during reperfusion after cerebral ischemia. J. Pharmacol. Exp. Ther. 274:1995;1167-1173.
20. Sriram K., Pai K.S., Boyd M.R., Ravindranath V. Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice. Brain Res. 749:1997;44-52.
21. Thomas J.A., Poland B., Honzatko R. Protein sulfhydryls and their role in the antioxidant function of protein S-thiolation. Arch. Biochem. Biophys. 319:1995;1-9.
22. Vannucci R.C., Connor J.R., Mauger D.T., Palmer C., Smith M.B., Towfighi J., Vannucci S.J. Rat model of perinatal hypoxic-ischemic brain damage. J. Neurosci. Res. 55:1999;158-163.
23. Wallin C., Puka-Sundvall M., Hagberg H., Weber S.G., Sandberg M. Alterations in glutathione and amino acid concentrations after hypoxia-ischemia in the immature rat brain. Brain Res. Dev. Brain Res. 125:2000;51-60.
24. Williams G.D., Towfighi J., Smith M.B. Cerebral energy metabolism during hypoxia-ischemia correlates with brain damage: a 31P NMR study in unanesthetized immature rats. Neurosci. Lett. 170:1994;31-34.