Histamine n-methyltransferase gene polymorphisms in chinese and their relationship with enzyme activity in erythrocytes

Pharmacogenetics

Volumn 13, Issue 7, 2003, Pages 389-397

  Chen, Guo Lin ^a   Wang, Haijian ^b,c   Wang, Wei ^a   Xu, Zhen Hua ^a   Zhou, Gan ^a   He, Fuchu ^b,c,d   Zhou, Hong Hao ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^c CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^d TSINGHUA UNIVERSITY   (China)

Author keywords

Chinese; Genotype phenotype correlation; Histamine; Histamine N methyltransferase; HNMT; Single nucleotide polymorphism

Indexed keywords

HISTAMINE METHYLTRANSFERASE; S ADENOSYLMETHIONINE;

ADULT; ARTICLE; CHINESE; DNA FLANKING REGION; ENZYME ACTIVITY; ERYTHROCYTE MEMBRANE; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC REGULATION; GENETIC SCREENING; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; METHYLATION; NEUROTRANSMITTER RELEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOOTH MUSCLE CONTRACTION; STOMACH ACID SECRETION;

3' UNTRANSLATED REGIONS; 5' FLANKING REGION; ADOLESCENT; ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; ERYTHROCYTES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC SCREENING; HAPLOTYPES; HISTAMINE N-METHYLTRANSFERASE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS; VARIATION (GENETICS);

EID: 0038180259     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200307000-00004     Document Type: Article

References (42)

1. Maslinski C. Histamine and its metabolism in mammals. Part 2. Catabolism of histamine and histamine liberation. Agents Actions 1975; 5:183-225.
2. Novak I, Falus A. Molecular biology and role of histamine in physiological and pathological reactions. A review. Acta Biol Hung 1997; 48:385-394.
3. Okinaga S, Ohrui T, Nakazawa H, Yamauchi K, Sakurai E, Watanabe T, et al. The role of HMT (histamine N-methyltransferase) in airways: a review. Methods Find Exp Clin Pharmacol 1995; 17 (suppl C):16-20.
4. Schwartz JC, Arrang MM, Garbarg M, Pollaed H, Ruat M. Histaminergic transmission in the mammalian brain. Physiol Rev 1991; 71:1-51.
5. Barnes PJ, Chung KF, Page CP. Inflammatory mediators of asthma: an update. Pharmacol Rev 1998; 50:515-596.
6. Yan L, Galinsky RE, Bernstein JA, Liggett SB, Weinshilboum RM. Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. Pharmacogenetics 2000; 10:261-266.
7. Fernandez-Novoa L, Cacabelos R. Histamine function in brain disorders. Behav Brain Res 2001; 124:213-233.
8. Yan L, Szumlanski CL, Rice SR, Sobell JL, Lachman HM, Weinshilboum RM. Histamine N-methyltransferase functional polymorphism: lack of association with schizophrenia. Am J Med Genet 2000; 96:404-406.
9. Schneider C, Risser D, Kirchner L, Kitzmuller E, Cairns N, Prast H, et al. Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease. Neurosci Lett 1997; 222:183-186.
10. Kim SH, Krapfenbauer K, Cheon MS, Fountoulakis M, Cairns NJ, Lubec G. Human brain cytosolic histamine-N-methyltransferase is decreased in Down syndrome and increased in Pick's disease. Neurosci Lett 2002; 321:169-172.
11. Passani MB, Bacciottini L, Mannaioni PF, Blandina P. Central histaminergic system and cognition. Neurosci Biobehav Rev 2000; 24:107-113.
12. Smith IR. Sidechain-modified histamine analogues as substrates for histamine N-methyltransferase. Biochem Pharmacol 1982; 31:2297-2300.
13. 3 receptor agonists and antagonists. Trends Pharmacol Sci 1998; 19:177-183.
14. 3 receptor agonist prodrug. J Pharmacol Exp Ther 1997; 281:1085-1094.
15. Fozard JR. BP-294 Ste Civile Bioprojet. Curr Opin Investig Drugs 2000; 1:86-89.
16. Scott MC, Van Loon JA, Weinshilboum RM. Pharmacogenetics of N-methylation: heritability of human erythrocyte histamine N-methylfransferase activity. Clin Pharmacol Ther 1988; 43:256-262.
17. Price RA, Scott MC, Weinshilboum RM. Genetic segregation analysis of red blood cell (RBC) histamine N-methyltransferase (HNMT) activity. Genet Epidemiol 1993; 10:123-131.
18. De Santi C, Donatelli P, Giulianotti PC, Pietrabissa A, Mosca F, Pacifici GM. Interindividual variability of histamine N-methyltransferase in the human liver and kidney. Xenobiotica 1998; 28:571-577.
19. Preuss CV, Wood TC, Szumlanski CL, Raftogianis RB, Otterness DM, Girard B, et al. Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity. Mol Pharmacol 1998; 53:708-717.
20. Pang YP, Zheng XE, Weinshilboum RM. Theoretical 3D model of histamine N-methyltransferase: insights into the effects of a genetic polymorphism on enzymatic activity and thermal stability. Biochem Biophys Res Commun 2001; 287:204-208.
21. Horton JR, Sawada K, Nishibori M, Zhang X, Cheng X. Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Structure 2001; 9:837-849.
22. Chen GL, Wang W, Xu ZH, Wang LS, Zhou G, Wang D, et al. Genotype-phenotype correlation for histamine N-methyltransferase in a Chinese Han population. Clin Chim Acta 2003; in press.
23. Chen GL, Xu ZH, Wang W, Wang GP, Zhou G, Wang D, et al. Analysis of the C314T and A595G mutations in histamine N-methyltransferase gene in a Chinese population. Clin Chim Acta 2002; 326:163-167.
24. Wang L, Thomae B, Eckloff B, Wieben E, Weinshilboum R. Human histamine N-methyltransferase pharmacogenetics: gene resequencing, promoter characterization, and functional studies of a common 5′-flanking region single nucleotide polymorphism (SNP). Biochem Pharmacol 2002; 64:699-710.
25. Pazmino PA, Weinshilboum RM. Human erythrocyte phenol O-methyltransferase: radiochemical microassay and biochemical properties. Clin Chim Acta 1978; 89:317-329.
26. Van Loon JA, Pazmiño PA, Weinshilboum RM. Human erythrocyte histamine N-methyltransferase: radiochemical microassay and biochemical properties. Clin Chim Acta 1985; 149:237-251.
27. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction form population data. Am J Hum Genet 2001; 68:978-989.
28. Rozas J, Rozas R. DnaSP version 3: An integrated program for molecular population genetics and molecular evolution analysis. Bioinformatics 1999; 15:174-175.
29. Saito S, Iida A, Sekine A, Miura Y, Sakamoto T, Ogawa C, et al. Identification of 197 genetic variations in six human methyltransferase genes in the Japanese population. J Hum Genet 2001; 46:529-537.
30. Floderus Y, Ross SB, Wetterberg L. Erythrocyte catechol-O-methyltransferase activity in a Swedish population. Clin Genet 1981; 19:389-392.
31. Boudikova B, Szumlanski C, Maidak B, Weinshilboum R. Human liver catechol-O-methyltransferase pharmacogenetics. Clin Pharmacol Ther 1990; 48:381-389.
32. Klemetsdal B, Straume B, Giverhaug T, Aarbakke J. Low catechol-O-methyltransferase activity in a Saami population. Eur J Clin Pharmacol 1994; 46:231-235.
33. Szumlanski CL, Honchel R, Scott MC, Weinshilboum RM. Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes. Pharmacogenetics 1992; 2:148-159.
34. Klemetsdal B, Straume B, Wist E, Aarbakke J. Identification of factors regulating thiopurine methyltransferase activity in a Norwegian population. Eur J Clin Pharmacol 1993; 44:147-152.
35. Jang IJ, Shin SG, Lee KH, Yim DS, Lee MS, Koo HH, et al. Erythrocyte thiopurine methyltransferase activity in a Korean population. Br J Clin Pharmacol 1996; 42:638-641.
36. Xie T, Ho SL, Ramsden D. Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription. Mol Pharmacol 1999; 56:31-38.
37. Kato S, Tora L, Yamauchi J, Masushige S, Bellard M, Chambon P. A far upstream estrogen response element of the ovalbumin gene contains several half-palindromic 5′-TGACC-3′ motifs acting synergistically. Cell 1992; 68:731-742.
38. Jonassen F, Granerus G, Wetterqvist H. Histamine metabolism and female sex hormones in women. Acta Obstet Gynecol Scand 1976; 55:387-394.
39. Axelrod J, Vesell ES. Heterogeneity of N- and O-methyltransferases. Mol Pharmacol 1970; 6:78-84.
40. Verburg KM, Henry DP. Histamine N-methyltransferase. In: Boulton AA, Baker GB, Yu PH (editors): Neuromethods: neurotransmitter enzymes. Clifton, NJ: Humana Press; 1986, pp. 147-204.
41. Barnes WG, Hough LB. Membrane-bound histamine N-methyltransferase in mouse brain: possible role in the synaptic inactivation of neuronal histamine. J Neurochem 2002; 82:1262-1271.
42. Okayama M, Yamauchi K, Sekizawa K, Okayama H, Sasaki H, Inamura N, et al. Localization of histamine N-methyltransferase messenger RNA in human nasal mucosa. J Allergy Clin Immunol 1995; 95:96-102.