Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency

Journal of Biological Chemistry

Volumn 278, Issue 28, 2003, Pages 26127-26134

  Leimkühler, Silke ^a   Freuer, Andrea ^a   Araujo, José Angel Santamaria ^a   Rajagopalan, K V ^b   Mendel, Ralf R ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYME KINETICS; ESCHERICHIA COLI; MOLYBDENUM; PATIENT TREATMENT; PROTEINS;

HOMOLOGY;

MUTAGENESIS;

BACTERIAL PROTEIN; CARBOXYLIC ACID DERIVATIVE; MOLYBDENUM; MOLYBDOPTERIN; MOLYBDOPTERIN SYNTHASE; PROTEIN MOAD; PROTEIN MOAE; THIOCARBOXYLATE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; ENZYME KINETICS; ENZYME MECHANISM; ENZYME PURIFICATION; ESCHERICHIA COLI; GENE MUTATION; HUMAN; METABOLIC DISORDER; MOLECULAR CLONING; MOLECULAR INTERACTION; MOLYBDENUM COFACTOR DEFICIENCY; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; PROTEIN ASSEMBLY; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; CLONING, MOLECULAR; COENZYMES; DNA, COMPLEMENTARY; ESCHERICHIA COLI; GENE LIBRARY; GENETIC COMPLEMENTATION TEST; HUMANS; METALLOPROTEINS; MOLECULAR SEQUENCE DATA; MOLYBDENUM; MUTAGENESIS, SITE-DIRECTED; MUTATION; NITRATE REDUCTASE; NITRATE REDUCTASES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PTERIDINES; SEQUENCE HOMOLOGY, AMINO ACID; SULFURTRANSFERASES; TIME FACTORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0038168025     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303092200     Document Type: Article

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