The effect of inhaled heparin on airway responsiveness to histamine and leukotriene D4

Allergy and Asthma Proceedings

Volumn 24, Issue 1, 2003, Pages 59-65

  Stelmach, Iwona ^a   Jerzynska, Joanna ^a   Stelmach, Wlodzimierz ^b   Majak, Pawel ^a   Brzozowska, Agnieszka ^a   Gorski, Pawel ^c   Kuna, Piotr ^c  

^a M Curie Hospital   (Poland)

^b Regional Health Authority   (Poland)

^c MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; HISTAMINE; LEUKOTRIENE D4; PLACEBO; ANTIINFLAMMATORY AGENT; BRONCHOCONSTRICTING AGENT;

ADOLESCENT; ADULT; AIRWAY; ALLERGIC ASTHMA; ANAMNESIS; ARTICLE; BRONCHUS HYPERREACTIVITY; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; MALE; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; CHEMICALLY INDUCED DISORDER; CHILD WELFARE; COMPARATIVE STUDY; DOSE RESPONSE; FORCED EXPIRATORY VOLUME; INHALATION TEST; INHALATIONAL DRUG ADMINISTRATION; NOSE PROVOCATION TEST; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; ADOLESCENT; ANTI-INFLAMMATORY AGENTS; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTOR AGENTS; CHILD; CHILD WELFARE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FORCED EXPIRATORY VOLUME; HEPARIN; HISTAMINE; HUMANS; LEUKOTRIENE D4; MALE; NASAL PROVOCATION TESTS; PREDICTIVE VALUE OF TESTS; TREATMENT OUTCOME;

EID: 0038161147     PISSN: 10885412     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. American Thoracic Society Workshop. Medical Section of The American Lung Association. Immunobiology of asthma and rhinitis. Pathogenic factors and therapeutic options. Am J Respir Crit Care Med 160:1778-1787, 1999.
2. Ferguson AC, Whitelaw M, and Brown H. Correlation of bronchial eosinophil and mast cell activation with bronchial hyperresponsiveness in children with asthma. J Allergy Clin Immunol 90:609-613, 1992.
3. Arm JP. O'Hickey SP, Hawksworth RJ, et al. Asthmatic airways have a disproportionate hyperresponsiveness to LTE4, as compared with normal airways, but not to LTC4, LTD4, methacholine, and histamine. Am Rev Respir Dis 142:1112-1118, 1990.
4. Bisgaard H, Groth S, and Madsen F. Bronchial hyperreactivity to leukotriene D4 and histamine in exogenous asthma. BMJ 290:1468-1471, 1985.
5. Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220:568-575, 1983.
6. Kalpaklioglu AF, Saryal S, and Demirel YS. Effect of pretreatment with heparin on airway resistance and cutaneous response. J Asthma 34:337-343, 1997.
7. Polosa R, Magri S. Vancheri C, et al. Time course of changes in adenosine 5′-monophosphate airway responsiveness with inhaled heparin in allergic asthma. J Allergy Clin Immunol 99:338-344, 1997.
8. Ceyhan B, and Celikel T. Effect of inhaled heparin on methacholine-induced bronchial hyperreactivity. Chest 107:1009-1012, 1995.
9. National Institutes of Health (NIH). Guidelines for the diagnosis and management of asthma. Highlights of the Expert Panel Report 2, NIH Publication No. 97-4051A, May 1997.
10. Crapo RO, Hankinson JL, and Irvin C. Standardization of spirometry. Am J Respir Crit Care Med 152:1107-1136, 1995.
11. Cockcroft DW, Murdock KY, and Mink JT. Determination of histamine PC20. Chest 54:505-506, 1983.
12. Ahmed T, Abraham WM, and D'Brot J. Effects of inhaled heparin on immunologic and nonimmunologic bronchoconstrictor responses in sheep. Am Rev Respir Dis 145:566-570, 1992.
13. Tutluoglu B, Gurbuz N, Atis S, et al. Effects of heparin on hypertonic potassium chloride-induced bronchoconstriction. Ann Pharmacother 35:1161-1165, 2001.
14. Tranfa CM, Vatrella A, Parrella R, et al. Effect of inhaled heparin on water-induced bronchoconstriction in allergic asthmatics. Eur J Clin Pharmacol 57:5-9, 2001.
15. Bendstrup KE, Newhouse MT, Pedersen OF, et al. Characterization of heparin aerosols generated in jet and ultrasonic nebulizers. J Aerosol Med 12:17-25, 1999.
16. Bendstrup KE, Chambers CB, Jensen JI, et al. Lung deposition and clearance of inhaled (99m)Tc-heparin in healthy volunteers. Am J Respir Crit Care Med. 160:1653-1658, 1999.
17. Barnes PJ. Effect of corticosteroids on airway hyperresponsiveness. Am Rev Respir Dis 141(suppl):S70-S76, 1990.
18. Boushey HA, Holtzman MJ, Sheller JR, et al. Bronchial hyperreactivity. Am Rev Respir Dis 121:389-413, 1980.
19. Ahmed T, Syriste T, Mendelssohn R, et al. Heparin prevents antigen-induced airway hyperresponsiveness: interference with IP3-mediated mast cell degranulation? J Appl Physiol 76:893-901, 1994.
20. Ahmed T, Syriste T, Lucio J, et al. Inhibition of antigen-induced airway and cutaneous responses by heparin: a pharmacodynamic study. J Appl Physiol 74:1492-1498, 1993.
21. Ahmed T, Garrigo J, and Danta I. Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N Engl J Med 329: 90-95, 1993.
22. Chilvers ER, Challiss RAJ, Willcocks AL, et al. Characterisation of stereospecific binding sites for inositol 1,4,5-triphosphate in airway smooth muscle. Br J Pharmacol 99:297-302, 1990.
23. Okona-Mensah KB, Shittu E, Page C, et al. Inhibition of serum and transforming growth factor beta (TGF-beta 1)-induced DNA synthesis in confluent airway smooth muscle by heparin. Br J Pharmacol 125:599-606, 1998.