Effect of pretreatment with heparin on pulmonary and cutaneous response

Journal of Asthma

Volumn 34, Issue 4, 1997, Pages 337-343

  Kalpaklioglu A F ^a,b   Demirel, Y S ^a   Saryal, S ^a   Misirligil, Z ^a  

^a ANKARA UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

Airway resistance; Bronchial hyperreactivity; Heparin; Methacholine; Skin test

Indexed keywords

CALCIUM; HEPARIN; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; METHACHOLINE;

ADULT; AGED; AIRWAY CONDUCTANCE; AIRWAY RESISTANCE; ALLERGIC ASTHMA; ARTICLE; BRONCHOSPASM; CALCIUM TRANSPORT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; INFLAMMATION; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG FUNCTION; MALE; MAST CELL; NEBULIZER; PRICK TEST; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; SKIN MANIFESTATION; SKIN TEST;

EID: 0030748641     PISSN: 02770903     EISSN: None     Source Type: Journal    
DOI: 10.3109/02770909709067224     Document Type: Article

References (29)

1. Dolowitz DA, Dougherty TF: The use of heparin as an anti-inflammatory agent. Laryngoscope 70:873 (1960).
2. Dolowitz DA, Dougherty TF: The use of heparin in the control of allergies. Ann Allergy 23:309 (1965).
3. Berridge MJ, Irvine RF: Inositol triphosphate, a novel second messenger in cellular signal transduction. Nature 312:315 (1984).
4. Ghosh TK, Eis PS, Mullaney JM, Ebert CL, Gill DL: Competitive reversible and potent antagonism of inositol 1,4,5-triphosphate activated calcium release by heparin. J Biol Cliem 263:11075 (1988).
5. Ahmed T, Abraham WM, D'Brot J: Effects of inhaled heparin on immunologic and nonimmunologic bronchoconstrictor responses in sheep. Am Rev Respir Dis 145:566 (1992).
6. Bowler SD, Smith SM, Lavercombe PS: Heparin inhibits the immediate response to antigen in the skin and lungs of allergic subjects. Am Rev Respir Dis 147:160 (1993).
7. O'Donnell WJ, Rosenberg MA, Kelleher K, Drazen JM, Israel E: Inhaled heparin does not protect asthmatics against antigen-induced bronchoconstriction. Arn Rev Respir Dis 145(Part 2):A422 (1992) (abstract).
8. Ahmed T, Syriste T, Lucio J, Abraham WM, Robinson MJ, D'Brot J: Inhibition of antigen-induced airway and cutaneous responses by heparin: A pharmacodynamic study. J Appl Physiol 74:1492 (1993).
9. Ceyhan B, Çelikel T: Effect of inhaled heparin on methacholine-induced bronchial hyperreactivity. Chest 107:1009 (1995).
10. Pavord I, Mudassar T, Bennett J, Wilding P, Knox A: The effect of inhaled heparin on bronchial reactivity to sodium metabisulphite and methacholine in patients with asthma. Eur Respir J 9:217 (1996).
11. Ahmed T, Garrigo J, Danta I: Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N Engl J Med 329:90 (1993).
12. Cockroft DW, Hargreave FE: Airway hyperresponsiveness: Definition, measurement and clinical relevance. In Asthma: Its Pathology and Treatment (Kaliner MA, Barnes P, Persson CGA, editors), Marcel Dekker, New York, 1991, 51-64.
13. Sterk PJ, Fabbri LM, Quanter J, Cockroft DW, O'Byrne PM, Anderson SD, Juniper EF, Malo JL: Airways responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Official statement of the European Respiratory Society. Eur Respir J 6(Suppl 16):53 (1993).
14. DuBois AB, Botelho SY, Comroe JH: A new method for measuring airway resistance in man using a body plethysmograph: Values in normal subjects and in patients with respiratory disease. J Clin Invest 35:327 (1956).
15. Lucio J, D'Brot J, Guo C, Abraham WM, Lichtenstein LM, Kagey-Sobotka A, Ahmed T: Immunologic mast cell-mediated responses and histamine release are attenuated by heparin. J Appl Physiol 73:1093 (1992).
16. Lane DA, Adams L: Non-anticoagulant uses of heparin. N Engl J Med 329:129 (1993).
17. Page CP: Are mast cells all bad? Postgrad Med J 67(Suppl 4):S6-S12 (1991).
18. Lessof MH, Gant V, Hinuma K, Murphy GM, Dowling RH: Recurrent urticaria and reduced diamine oxidase activity. Clin Exp Allergy 22:373 (1989).
19. Fredens K, Dahl R, Venge P: In vitro studies of the interaction between heparin and eosinophil cationic protein. Allergy 46:27 (1991).
20. Bowler S: Heparin, allergy, mast cells and asthma. In Heparin and Related Polysaccharides: New Directions for Old Drugs. Conference documentation from meeting organized by IBC Technical Services, London, Dec 29/30, 1988.
21. Szczeklik A, Schmitz-Schumann M, Krzanowski M, Virchow SR: Delayed generation of thrombin in clotting blood of atopic patients with hayfever and asthma. Clin Exp Allergy 21:411 (1991).
22. Lasser EC, Simon RA, Lyon SG, Hamblin AE, Stein R: Heparin-like anticoagulants in asthma. Allergy 42:619 (1987).
23. Lasser EC, Berry C, Kortman K: Diminished atherosclerotic arterial calcifications in asthma. Allergy 42:549 (1987).
24. 2-agonists. Lancet 337:717 (1991).
25. Fryer AD, Jacoby DB: Function of pulmonary M2 receptors in antigen-challenged guinea-pigs is restored by heparin and poly-L-glutamate. J Clin Invest 90:2292 (1992).
26. Coyle AJ, Mintner W, Irwin CG: Cationic proteins alter smooth muscle function by an epithelium-dependent mechanism. J Appl Physiol 74:1761 (1993).
27. Ahmed T, Syriste T, Mendelssohn R, Sorace D, Mansour E, Lansing M, Abraham M, Robinson MJ: Heparin prevents antigen-induced airway hyperresponsiveness: Interference with IPs-mediated mast cell degranulation? J Appl Physiol 76:893 (1994).
28. Ruppel G: Pulmonary mechanics. In Normal of Pulmonary Testing, 5th ed. CV Mosby, St Louis, 1991.
29. Jaques LB: Heparins-anionic poly electrolyte drugs. Pharmacol Rev 31:99 (1979).