메뉴 건너뛰기




Volumn 80, Issue 1, 2003, Pages 99-104

A phase II study of topical ceramides for cutaneous breast cancer

Author keywords

Apoptosis; Ceramides; Clinical trial; Cutaneous cancer; Quality of life

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CERAMIDE DERIVATIVE;

EID: 0038160944     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024409123726     Document Type: Article
Times cited : (25)

References (22)
  • 1
    • 0028841289 scopus 로고
    • Analysis of the factors influencing quality of life of patients with advanced or recurrent breast cancer
    • Shimozuma K, Sonoo H, Ichihara K, et al.: Analysis of the factors influencing quality of life of patients with advanced or recurrent breast cancer. Jpn J Surg 25: 874-882, 1995
    • (1995) Jpn J Surg , vol.25 , pp. 874-882
    • Shimozuma, K.1    Sonoo, H.2    Ichihara, K.3
  • 2
    • 0027296991 scopus 로고
    • Cutaneous metastases in patients with metastatic carcinoma: A retrospective study of 4020 patients
    • Lookingbill DP, Pangler N, Helm KF, et al.: Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol 29: 228-236, 1993
    • (1993) J Am Acad Dermatol , vol.29 , pp. 228-236
    • Lookingbill, D.P.1    Pangler, N.2    Helm, K.F.3
  • 3
    • 0033048898 scopus 로고    scopus 로고
    • Phase II trial with topically applied miltefosine solution in patients with skin-metastasized breast cancer
    • Terwogt JMM, Mandjes IAM, Sindermann H, et al.: Phase II trial with topically applied miltefosine solution in patients with skin-metastasized breast cancer. Br J Cancer 79: 1158-1161, 1999
    • (1999) Br J Cancer , vol.79 , pp. 1158-1161
    • Terwogt, J.M.M.1    Mandjes, I.A.M.2    Sindermann, H.3
  • 4
    • 0035503414 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer
    • Leonard R, Hardy J, van Tienhoven G, et al.: Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer. J Clin Oncol 19: 4150-4159, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 4150-4159
    • Leonard, R.1    Hardy, J.2    Van Tienhoven, G.3
  • 5
    • 0033638448 scopus 로고    scopus 로고
    • Phase II study of miltefosine 6% solution as topical treatment of skin metastases in breast cancer patients
    • Smorenburg CH, Seynaeve C, Bontenbal M, et al.: Phase II study of miltefosine 6% solution as topical treatment of skin metastases in breast cancer patients. Anticancer Drugs 11: 825-828, 2000
    • (2000) Anticancer Drugs , vol.11 , pp. 825-828
    • Smorenburg, C.H.1    Seynaeve, C.2    Bontenbal, M.3
  • 6
    • 0031047459 scopus 로고    scopus 로고
    • Miltefosine in recurrent cutaneous breast cancer
    • Clive S, Leonard RC: Miltefosine in recurrent cutaneous breast cancer. Lancet 349: 621-622, 1997
    • (1997) Lancet , vol.349 , pp. 621-622
    • Clive, S.1    Leonard, R.C.2
  • 8
    • 0030670626 scopus 로고    scopus 로고
    • Activation of CD95 signaling by ceramide mediates cancer therapy-induced apoptosis
    • Herr I, Wilhelm D, Bohler T, et al.: Activation of CD95 signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J 16: 6200-6208, 1997
    • (1997) EMBO J , vol.16 , pp. 6200-6208
    • Herr, I.1    Wilhelm, D.2    Bohler, T.3
  • 9
    • 0026723048 scopus 로고
    • Ceramide stimulates a cytosolic protein phosphatase
    • Dobrowsky RT, Hannun YA: Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem 267: 5048-5051, 1992
    • (1992) J Biol Chem , vol.267 , pp. 5048-5051
    • Dobrowsky, R.T.1    Hannun, Y.A.2
  • 10
    • 0027202552 scopus 로고
    • Ceramide activates a heterotrimeric protein phosphatase A2
    • Dobrowsky RT, Kamibayishi C, Mumby MC, et al.: Ceramide activates a heterotrimeric protein phosphatase A2. J Biol Chem 268: 15523-15530, 1993
    • (1993) J Biol Chem , vol.268 , pp. 15523-15530
    • Dobrowsky, R.T.1    Kamibayishi, C.2    Mumby, M.C.3
  • 11
    • 0028122397 scopus 로고
    • Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
    • Wolff RA, Dobrowsky TR, Bielawska A, et al.: Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem 269: 19609-19609, 1994
    • (1994) J Biol Chem , vol.269 , pp. 19609-19609
    • Wolff, R.A.1    Dobrowsky, T.R.2    Bielawska, A.3
  • 12
    • 0027965006 scopus 로고
    • Protein kinase C is critical for NF kappa B dependent promotor activation by sphingomyelinase
    • Lozano J, Berra E, Muncio MM, et al.: Protein kinase C is critical for NF kappa B dependent promotor activation by sphingomyelinase. J Biol Chem 269: 19200-19202, 1994
    • (1994) J Biol Chem , vol.269 , pp. 19200-19202
    • Lozano, J.1    Berra, E.2    Muncio, M.M.3
  • 13
    • 0029003788 scopus 로고
    • Protein kinase C is a molecular switch in signal transduction of TNF alpha, bifunctionally regulated by ceramide and arachadonic acid
    • Muller G, Ayoub M, Storz P, et al.: Protein kinase C is a molecular switch in signal transduction of TNF alpha, bifunctionally regulated by ceramide and arachadonic acid. EMBO J 14: 1961-1969, 1995
    • (1995) EMBO J , vol.14 , pp. 1961-1969
    • Muller, G.1    Ayoub, M.2    Storz, P.3
  • 14
    • 0027461121 scopus 로고
    • Activation of the sphingomyelin signaling pathway in intact EL4 cells and in cell-free system by IL- 1 beta
    • Mathias S, Younes A, Kan C, et al.: Activation of the sphingomyelin signaling pathway in intact EL4 cells and in cell-free system by IL-1 beta. Science 259: 519-522, 1993
    • (1993) Science , vol.259 , pp. 519-522
    • Mathias, S.1    Younes, A.2    Kan, C.3
  • 15
    • 0027197994 scopus 로고
    • Substrate recognition by ceramide-activated protein kinase: Evidence that kinase activity is protein-directed
    • Joseph CK, Byun HS, Bittman R, et al.: Substrate recognition by ceramide-activated protein kinase: evidence that kinase activity is protein-directed. J Biol Chem 268: 20002-20006, 1993
    • (1993) J Biol Chem , vol.268 , pp. 20002-20006
    • Joseph, C.K.1    Byun, H.S.2    Bittman, R.3
  • 16
    • 0027968517 scopus 로고
    • Renaturation and TNF alpha stimulation of a 97-kDa ceramide-activated protein kinase
    • Liu J, Mathias S, Yang Z, et al.: Renaturation and TNF alpha stimulation of a 97-kDa ceramide-activated protein kinase. J Biol Chem 269: 3047-3052, 1994
    • (1994) J Biol Chem , vol.269 , pp. 3047-3052
    • Liu, J.1    Mathias, S.2    Yang, Z.3
  • 17
    • 0028277981 scopus 로고
    • Direct stimulation of vav guanine nucleotide exchange activity for ras by phorbal diesters and diglyceride
    • Gulbins E, Coggeshall M, Baier G, et al.: Direct stimulation of vav guanine nucleotide exchange activity for ras by phorbal diesters and diglyceride. Mol Cell Biol 14: 4749-4758, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 4749-4758
    • Gulbins, E.1    Coggeshall, M.2    Baier, G.3
  • 18
    • 0347537940 scopus 로고    scopus 로고
    • Requirement for ceramide-initiated stress-activated protein kinase/c-jun aminoterminal kinase signaling in stress-induced apoptosis
    • Verheij M, Bose R, Lin XH, et al.: Requirement for ceramide-initiated stress-activated protein kinase/c-jun aminoterminal kinase signaling in stress-induced apoptosis. Nature 380: 75-79, 1996
    • (1996) Nature , vol.380 , pp. 75-79
    • Verheij, M.1    Bose, R.2    Lin, X.H.3
  • 19
    • 0028981358 scopus 로고
    • Ceramide activates the stress-activated protein kinases
    • Westick JK, Bielawska ARE, Dbaibo GS, et al.: Ceramide activates the stress-activated protein kinases. J Biol Chem 270: 22689-22692, 1995
    • (1995) J Biol Chem , vol.270 , pp. 22689-22692
    • Westick, J.K.1    Bielawska, A.R.E.2    Dbaibo, G.S.3
  • 20
    • 0036290828 scopus 로고    scopus 로고
    • Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis
    • Lopez-Marure R, Guitierrez G, Mendoza C, et al.: Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun 10: 1028-1036, 2002
    • (2002) Biochem Biophys Res Commun , vol.10 , pp. 1028-1036
    • Lopez-Marure, R.1    Guitierrez, G.2    Mendoza, C.3
  • 21
    • 0027477142 scopus 로고
    • Anti-tumor activity of ceramides and glycosphingolipids in a murine tumor system
    • Maru M, Haraguchi M, Higashi H, et al.: Anti-tumor activity of ceramides and glycosphingolipids in a murine tumor system. Int J Cancer 53: 645-650, 1993
    • (1993) Int J Cancer , vol.53 , pp. 645-650
    • Maru, M.1    Haraguchi, M.2    Higashi, H.3
  • 22
    • 0021810417 scopus 로고
    • Defining lipid transport pathways in animal cells
    • Pagano RE, Sleight RG.: Defining lipid transport pathways in animal cells. Science 229: 1051-1057, 1985
    • (1985) Science , vol.229 , pp. 1051-1057
    • Pagano, R.E.1    Sleight, R.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.