Comparing the effects of stage and duration of retinoic acid exposure on amphibian limb development: Chronic exposure results in mortality, not limb malformations

Toxicological Sciences

Volumn 74, Issue 1, 2003, Pages 139-146

  Degitz, Sigmund J ^a   Holcombe, Gary W ^a   Kosian, Patricia A ^a   Tietge, Joseph E ^a   Durham, Elizabeth J ^a   Ankley, Gerald T ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Amphibian limb development; Limb malformations; Retinoic acid exposure; Retinoid signaling pathways

Indexed keywords

RETINOIC ACID; RETINOID; WATER; XENOBIOTIC AGENT;

AMPHIBIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; EMBRYO DEVELOPMENT; FREQUENCY ANALYSIS; HINDLIMB; LARVAL STAGE; LIFE CYCLE; LIMB BUD; LIMB DEVELOPMENT; LIMB MALFORMATION; LONG TERM EXPOSURE; METAMORPHOSIS; MORTALITY; NONHUMAN; PRENATAL EXPOSURE; SIGNAL TRANSDUCTION; SURVIVAL; TADPOLE; TAIL; TERATOLOGY; UNITED STATES; XENOPUS LAEVIS;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; BODY WEIGHT; EMBRYONIC AND FETAL DEVELOPMENT; EXTREMITIES; LARVA; METAMORPHOSIS, BIOLOGICAL; RECEPTORS, RETINOIC ACID; TRETINOIN; WATER; XENOPUS LAEVIS;

AMPHIBIA; ANIMALIA; VERTEBRATA; XENOPUS LAEVIS;

EID: 0038155493     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg098     Document Type: Article

References (31)

1. Ankley, G. T., Diamond, S. A., Tietge, J. E., Holcombe, G. W., Jensen, K. M., DeFoe, D. L., and Peterson, R. (2002). Assessment of the risk of solar ultraviolet radiation to amphibians. I. Dose-dependent induction of hindlimb malformation in Northern leopard frog (Rana Pipiens). Environ. Sci. Technol. 36, 2853-2858.
2. Ankley, G. T., Tietge, J. E., DeFoe, D. L., Jensen, K. M., Holcombe, G. W., Durhan, E. J., and Diamond, S. A. (1998). Effects of ultraviolet light and methoprene on survival and development of Rana pipiens. Environ. Toxicol. Chem. 17, 2530-2542.
3. Ankley, G. T., Tietge, J. E., Holcombe, G. W., DeFoe, D. L., Diamond, S. A., Jensen, K. M., and Degitz, S. J. (2000). Effects of laboratory ultraviolet radiation and natural sunlight on survival and development of Rana pipiens. Can. J. Zool. /Rev. Can. Zool. 78, 1092-1100.
4. Creech Kraft, J., and Juchau, M. R. (1995). Xenopus laevis: A model system for the study of embryonic retinoid metabolism. III. Isomerization and metabolism of all-trans retinoic acid and 9-cis-retinoic acid and their dysmorphogenic effects in embryos during neurulation. Drug. Metab. Dispos. 23, 1058-1071.
5. Creech Kraft, J., Kimelman, D., and Juchau, M. R. (1995). Xenopus laevis: a model system for the study of embryonic retinoid metabolism. I. Embryonic metabolism of 9-cis-and all-trans-retinals and retinols to their corresponding acid forms. Drug Metab. Dispos. 23, 72-82.
6. Dawid, I. B., Otani, H., Curtiss, P., and Taira, M. (1993). Regulatory interactions during embryogenesis in Xenopus laevis. C. R. Acad. Sci. III 316, 945-958.
7. Degitz, S. J., Kosian, P. A., Makynen, E. A., Jensen, K. M., and Ankley, G. T. (2000). Stage- and species-specific developmental toxicity of all-trans retinoic acid in four native North American ranids and Xenopus laevis. Toxicol. Sci. 57, 264-274.
8. Gardiner, D. M., and Hoppe, D. M. (1999). Environmentally induced limb malformation in mink frogs (Rana septentrionalis). J. Exp. Zool. 284, 207-216.
9. Johnson, P. T. J., Lunde, K. B., Haight, R. W., Bowerman, J., and Blaustein, A. R. (2001). Ribeiroia ondatrae (Trematoda: Digenea) infection induces severe limb malformations in western toads (Bufo boreas) Can. J. Zool. 79, 370-379,
10. Johnson, P. T. J., Lunde, K. B., Ritche, E. G., and Launer, A. E. (1999). The effect of trematode infection on amphibian limb development and survivorship. Science 284, 802-804.
11. Johnson, P. T. J., Lunde, K. B., Thurman, E. M., Ritchie, E. G., Wray, S. N., Sutherland, D. R., Kapfer, J. M., Frest, T. J., Bowerman, J., and Blaustein, A. R. (2002). Parasite (Ribeiroia ondatrae) infection linked to amphibian malformations in the western United States. Ecol. Monogr. 72, 151-168.
12. Kahl, M. D., Russom, C. L., DeFoe, D. L., and Hammermeister, D. E. (1999). Saturation units for use in aquatic bioassays. Chemosphere 39, 539-551.
13. Kaplan, E. L. (1958). Nonparametric estimation from incomplete observations, J. Am. Stat. Assoc. 53, 457-481.
14. Kiesecker, J. M. (2002) Synergism between trematode infection and pesticide exposure: A link to amphibian limb deformities in nature? Proc. Natl. Acad. Sci. 99, 9900-9904.
15. Kochhar, D. M. (1977). Cellular basis of congenital limb deformity induced in mice by vitamin A. In Morphogenesis and Malformation of the Limb (D. Bergsma and W. Lenz, Eds.), pp. 111-154. A. R. Liss, New York, NY.
16. Kochhar, D. M., Penner, J. D., and Tellone, C. I. (1984). Comparative teratogenic activity of two retinoids: Effects on palate and limb development. Terat. Carcin. Mutag. 4, 377-387.
17. Leroy, P., and De Robertis, E. M. (1992). Effects of lithium chloride and retinoic acid on the expression of genes from the Xenopus laevis Hox 2 complex. Dev. Dyn. 194, 21-32.
18. Maden, M. (1983). The effects of vitamin A on limb regeneration in Rana temporaria. Dev. Biol. 98, 409-416.
19. Maden, M. (1985). Retinoids and the control of pattern in regenerating limbs. Ciba. Found. Symp. 113, 132-155.
20. Nieuwkoop, P. D., and Faber, F. (1994). Normal table of Xenopus laevis. Garland Publishing, New York.
21. Rutledge, J. C., Shourbaji, A. G., Hughes, L. A., Polifka, J. E., Cruz, Y. P., and Bishop, J. B. (1994). Limb and lower-body duplications induced by retinoic acid in mice. Proc. Natl. Acad. Sci. 91, 5436-5440.
22. Scadding, S. R., and Maden, M. (1986a). Comparison of the effects of vitamin A on limb development and regeneration in the axolotl, Ambystoma mexicanum. J. Embryol. Exp. Morph. 91, 19-34.
23. Scadding, S. R., and Maden, M. (1986b). Comparison of the effects on vitamin A on limb development and regeneration in Xenopus laevis tadpoles. J. Embryol. Exp. Morphol. 91, 35-53.
24. Sulik, K. K., Cook, C. S., and Webster, W. S. (1988). Teratogens and craniofacial malformation: relationships to cell death. Development 103(Suppl.), 213-232.
25. Sulik, K. K., Dehart, D. B., Rogers, J. M., and Chernoff, N. (1995). Teratogenicity of low doses of all-trans retinoic acid in presomite mouse embryos. Teratology 51, 398-403.
26. Summerbell, D. (1983). The effect of local application of retinoic acid to the anterior margin of the developing chick limb. J. Embryol. Exp. Morph. 78, 269-289.
27. Sucov, H. M., and Evans, R. M. (1995). Retinoic acid and retinoic acid receptors in development. Mol. Neurobiol. 10, 169-84.
28. Thoms, S. D., and Stocum, D. L. (1984). Retinoic acid induced pattern duplication in regenerating urodele limbs. Dev. Biol. 103, 319-328.
29. Tickle, C., Alberts, B., Wolpert, L., and Lee, J. (1982). Local application of retinoic acid to the limb bud mimics the action of the polarizing region. Nature 296, 564-566.
30. Tickle, C., Lee, J., and Eichele, G. (1985). A quantitative analysis of the effect of all-trans-retinoic acid on the pattern of chick wing development. Dev. Biol. 109, 82-95.
31. Vickers, T. H. (1985). Embryo lethality in rats caused by retinoic acid. Teratology 31, 19-33.