The coxsackievirus and adenovirus receptor acts as a tumour suppressor in malignant glioma cells

British Journal of Cancer

Volumn 88, Issue 9, 2003, Pages 1411-1416

  Kim, M ^a   Sumerel, L A ^a   Belousova, N ^a   Lyons, G R ^a   Carey, D E ^b   Krasnykh, V ^a   Douglas, J T ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

CAR; Glioma; Tumour suppressor

Indexed keywords

ADENOVIRUS RECEPTOR; ADENOVIRUS VECTOR; COXSACKIEVIRUS RECEPTOR; IMMUNOGLOBULIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; VIRUS RECEPTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; BLADDER CANCER; CANCER CELL; CANCER INHIBITION; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; GENE THERAPY; GLIOMA CELL; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DOMAIN;

ANIMALS; BRAIN NEOPLASMS; CLONING, MOLECULAR; DNA, COMPLEMENTARY; FEMALE; FLOW CYTOMETRY; GENES, TUMOR SUPPRESSOR; GENETIC VECTORS; GLIOMA; HUMANS; MICE; MICE, NUDE; MUTAGENESIS; PLASMIDS; RECEPTORS, VIRUS; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0038146845     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600932     Document Type: Article

References (22)

1. Anon (1998) Use and application of adenovirus expression vectors. In Cells: A Laboratory Manual, Leinwand LA (ed) Vol. 2, pp 90.1-90.28. New York: Cold Spring Harbor Laboratory Press
2. Barnett BG, Crews CJ, Douglas JT (2002) Targeted adenoviral vectors. Biochim Biophys Acta 1575: 1-14
3. Bergelson JM, Krithivas A, Celi L, Droguett G, Horwitz MS, Wickham T, Crowell RL, Finberg RW (1998) The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J Virol 71: 415-419
4. Blackwell JL, Miller CR, Douglas JT, Li H, Reynolds PN, Carroll WR, Peters GE, Strong TV, Curiel DT (1999) Retargeting to EGFR enhances adenovirus infection of squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 125: 856-863
5. Dethlefsen LA, Prewitt JM, Mendelsohn ML (1968) Analysis of tumor growth curves. J Natl Cancer Inst 40: 389-405
6. Dmitriev I, Krasnykh V, Miller CR, Wang M, Kashentseva E, Mikheeva G, Belousova N, Curiel DT (1998) An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J Virol 72: 9706-9713
7. Fechner H, Haack A, Wang H, Wang X, Eizema K, Pauschinger M, Schoemaker RG, van Veghel R, Houtsmuller AB, Schultheiss H-P, Lamers JMJ, Poller W (1999) Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers. Gene Therapy 6: 1520-1535
8. Freimuth P, Springer K, Berard C, Hainfeld J, Bewley M, Flanagan J (1999) Coxsackievirus and adenovirus receptor amino-terminal immunoglobulin V-related domain binds adenovirus type 2 and fiber knob from adenovirus type 12. J Virol 73: 1392-1398
9. Graham F, Smiley J, Russell W, Nairn R (1977) Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 36: 59-72
10. Hemmi S, Geertsen R, Mezzacasa A, Peter I, Dummer R (1998) The presence of human coxsackievirus and adenovirus receptor is associated with efficient adenovirus-mediated transgene expression in human melanoma cell cultures. Hum Gene Ther 9: 2363-2373
11. Henry LJ, Xia D, Wilke ME, Deisenhofer J, Gerard RD (1994) Characterization of the knob domain of the adenovirus type 5 fiber protein expressed in Escherichia coli. J Virol 68: 5239-5246
12. Krasnykh V, Belousova N, Korokhov N, Mikheeva G, Curiel DT (2001) Genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage T4 fibritin. J Virol 75: 4176-4183
13. Li D, Duan L, Freimuth P, O'Malley BWJ (1999) Variability of adenovirus receptor density influences gene transfer efficiency and therapeutic response in head and neck cancer. Clin Cancer Res 5: 4175-4181
14. Louis N, Fender P, Barge A, Kitts P, Chroboczek J (1994) Cell-binding domain of adenovirus serotype 2 fiber. J Virol 68: 4104-4106
15. Miller CR, Buchsbaum DJ, Reynolds PN, Douglas JT, Gillespie GY, Mayo MS, Raben D, Curiel DT (1998) Differential susceptibility of primary and established human glioma cells to adenovirus infection: targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer. Cancer Res 58: 5738-5748
16. Okegawa T, Li Y, Pong RC, Bergelson JM, Zhou J, Hsieh JT (2000) The dual impact of coxsackie and adenovirus receptor expression on human prostate cancer gene therapy. Cancer Res 60: 5031-5036
17. Okegawa T, Pong RC, Li Y, Bergelson JM, Sagalowsky AI, Hsieh JT (2001) The mechanism of the growth-inhibitory effect of coxsackie and adenovirus receptor (CAR) on human bladder cancer: a functional analysis of CAR protein structure. Cancer Res 61: 6592-6600
18. Rauen KA, Sudilovsky D, Le JL, Chew KL, Hann B, Weinberg V, Schmitt LD, McCormick F (2002) Expression of the coxsackie adenovirus receptor in normal prostate and in primary and metastatic prostate carcinoma: potential relevance to gene therapy. Cancer Res 62: 3812-3818
19. Tomko RP, Xu R, Philipson L (1997) HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci USA 94: 3352-3356
20. van Raaij MJ, Chouin E, van der Zandt H, Bergelson JM, Cusack S (2000) Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution. Struct Fold Des 8: 1147-1155
21. Vanderkwaak TJ, Wang M, Gomez-Navarro J, Rancourt C, Dmitriev I, Krasnykh V, Barnes M, Siegal GP, Alvarez R, Curiel DT (1999) An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches. Gynecol Oncol 74: 227-234
22. Wang X, Bergelson JM (1999) Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection. J Virol 73: 2559-2562