Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: Kinetics and warfarin inhibition

Toxicology

Volumn 189, Issue 3, 2003, Pages 191-198

  Wilson, Christina R ^a   Sauer, John Michael ^b   Carlson, Gary P ^c   Wallin, Reidar ^d   Ward, Michael P ^a   Hooser, Stephen B ^a  

^a PURDUE UNIVERSITY   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c PURDUE UNIVERSITY   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Human; In vitro; Michaelis Menten kinetics; Species comparison; Vitamin K; Vitamin K epoxide reductase; Warfarin

Indexed keywords

OXIDOREDUCTASE; PHYTOMENADIONE OXIDE; UNCLASSIFIED DRUG; VITAMIN K1 2,3 EPOXIDE REDUCTASE; WARFARIN;

ANIMAL TISSUE; ARTICLE; CATTLE; DOG; DRUG INHIBITION; DRUG SENSITIVITY; ENZYME ACTIVITY; HORSE; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY; KINETICS; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT; SHEEP; SPECIES COMPARISON; SWINE;

BOVINAE; EQUIDAE; MURINAE; OVIS; SUIDAE;

EID: 0038121764     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(03)00133-1     Document Type: Article

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