Role of endogenous glucocorticoids in the healing of gastric erosions and chronic gastric ulcers in rats

Inflammopharmacology

Volumn 10, Issue 4-6, 2002, Pages 401-412

  Filaretova, L ^a   Bagaeva, T ^a   Podvigina, T ^a  

^a PAVLOV INSTITUTE OF PHYSIOLOGY   (Russian Federation)

Author keywords

Acetic acid; Adrenalectomy; Coldrestraint stress; Gastric lesions; Glucocorticoids; Healing; Indomethacin

Indexed keywords

ACETIC ACID; CORTICOSTERONE; GLUCOCORTICOID; INDOMETACIN; PROSTAGLANDIN;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLD STRESS; CONTROLLED STUDY; DISEASE SEVERITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH EROSION; STOMACH MUCOSA; STOMACH PROTECTION; STOMACH ULCER; ULCER HEALING; ULCEROGENESIS;

EID: 0038105848     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1163/156856002321544873     Document Type: Article

References (24)

1. Akana, S. F., et al. (1985). Corticosterone: narrow range required for normal body and thymus weight and ACTH, Am. J. Physiol. 249, R527-R532.
2. Black, H. E. (1988). The effects of steroids upon the gastrointestinal tract, Toxicol. Pathol. 16, 213-222.
3. Brzozowski, T., et al. (2001). Classic NSAID and selective cyclooxygenase (COX-1) and COX-2 inhibitors in healing of chronic gastric ulcers, Microsc. Res. Techn. 53, 343-353.
4. Carpani de Kaski, T., et al. (1995). Corticosteroids reduce regenerate repair of epithelium in experimental gastric ulcer, Gut 37, 613-616.
5. Filaretova, L. P., et al. (1998). Corticosterone increase inhibits stress-induced gastric erosions in rats, Am. J. Physiol. 274, G1024-G1030.
6. Filaretova, L. P., et al. (2001a). Various ulcerogenic stimuli are potentiated by glucocorticoid deficiency in rat, J. Physiol. (Paris) 95, 59-65.
7. Filaretova, L. P., et al. (2001b). Gastroprotective action of glucocorticoids during the formation and the healing of indomethacin-induced gastric erosions in rats, J. Physiol. (Paris) 95, 201-208.
8. Filaretova, L. P., et al. (2002a). Aggravation of nonsteroidal antiinflammatory drug gastropathy by glucocorticoid deficiency or blockade of glucocorticoid receptor in rats, Life Sci. 71, 2457-2468.
9. Filaretova, L., et al. (2002b). Mechanisms underlying protective action of endogenous glucocorticoids against indomethacin induced gastric injury in rats, Am. J. Physiol. 283, G1082-G1089.
10. Filaretova, L., et al. (2002c). Selective cyclooxygenase-2 inhibitor induced gastric mucosal damage in adrenalectomized rats, Inflammopharmacology 10, 413-422.
11. Ito, M., et al. (1990). Effect of N-(3-aminopropionyl)-L-histidinato zinc (Z-103) on healing and hydrocortisone-induced relapse of acetic acid ulcers in rats with limited food-intake time, Jpn. J. Pharmacol. 52, 513-521.
12. Lechin, F., et al. (1990). Plasma neurotransmitters and cortisol in duodenal ulcer patients. Role of stress, Dig. Dis. Sci. 35, 1313-1319.
13. 2 accelerate mucosal recovery from stress-induced gastric lesions via inhibition of apoptosis, J. Physiol. (Paris) 95, 361-367.
14. Kuwayama, H., et al. (1988). Effect of parenteral hydrocortisone sodium succinate on epithelial renewal in hamster gastric mucosa, Dig. Dis. Sci. 33, 1064-1069.
15. Kuwayama, H., et al. (1991). Effect of prostaglandin on hydrocortisone-induced delayed healing of chronic gastric ulcers in the rats, J. Clin. Gastroenterology 13 (Suppl.), 54-57.
16. Masferrer, J. L. and Seibert, K. (1994). Regulation of prostaglandin synthesis by glucocorticoids, Receptors 4, 25-30.
17. Mozsik, G., et al. (2001). The key-role of vagal nerve and adrenals in the cytoprotection and general gastric mucosal integrity, J. Physiol. (Paris) 95, 229-237.
18. Shigeta, J., et al. (1998). Role of cyclooxygenase-2 in the healing of gastric ulcers in rats, J. Pharmacol. Exp. Ther. 286, 1386-1390.
19. Szabo, S., et al. (1983). Role of the adrenal cortex in gastric mucosal protection by prostaglandins, sulfhydryls, and cimetidine in the rat, Gastroenterology 85, 1384-1390.
20. Takeuchi, K., et al. (1989). Bilateral adrenalectomy worsens gastric lesions induced by indomethacin in rats; Role of enhanced gastric motility, Gastroenterology 97, 284-293.
21. Takeuchi, K., et al. (2001). Gastrointestinal sparing anti-inflammatory drugs - effects on ulcerogenic and healing responses, Curr. Pharm. Des. 7, 49-69.
22. Tarnawski, A., et al. (2001). Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways, J. Physiol. (Paris) 95, 337-344.
23. Tsukimi, Y., et al. (2001). Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats, J. Physiol. Pharmacol. 52, 391-406.
24. Weusten, B. L., et al. (1993). Corticosteroid pulse therapy in active rheumatoid arthritis. Semin. Arthritis Rheum. 23, 183-192.