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Volumn 300, Issue 5624, 2003, Pages 1437-1439

Disrupted timing of discontinuous but not continuous movements by cerebellar lesions

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; PATIENT MONITORING; PATIENT TREATMENT;

EID: 0038103613     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083661     Document Type: Article
Times cited : (398)

References (35)
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    • (1993) Attention and Performance XIV , pp. 771-802
    • Ivry, R.B.1    Gopal, H.S.2
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    • J. Requin, G. Stelmach, Eds. (Kluwer, Norwell, MA) NATO Advanced Study Institute series
    • J. Jackson, J. A. Michon, in Tutorials in Motor Neuroscience, J. Requin, G. Stelmach, Eds. (Kluwer, Norwell, MA, 1991), NATO Advanced Study Institute series, vol. 62, pp. 169-198.
    • (1991) Tutorials in Motor Neuroscience , vol.62 , pp. 169-198
    • Jackson, J.1    Michon, J.A.2
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    • note
    • We focus on measures of variable error, operationalized as the standard deviation of the cycle durations. This measure has been commonly used in neuropsychological studies [e.g. (1)] to assess the contribution of different neural structures to timing based on the assumption that lesions add noise to the system.
  • 21
    • 0038150092 scopus 로고    scopus 로고
    • note
    • By "explicit," we mean that the action representation includes the specification of a temporal goal, as opposed to being a conscious representation as this term implies in the memory literature.
  • 22
    • 0038488704 scopus 로고    scopus 로고
    • note
    • Materiais and methods are available as supporting material on Science Online.
  • 24
    • 0038150093 scopus 로고    scopus 로고
    • note
    • Variability due to linear drift in cycle duration was removed by detrending (34). A regression line was fit to the time series for each trial, and the residuals were pooled across trials for each participant in each condition. The standard deviation of these residuals was divided by the mean cycle duration to obtain the coefficient of variation scores.
  • 25
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    • note
    • One concern with our within-subject comparison is that the difference between hands may be related to other factors, such as handedness. However, the lesions affected the dominant hand for five of the six patients; thus, any effect of handedness would work against our hypothesis.
  • 26
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    • G. Holmes, Brain 62, 1 (1939).
    • (1939) Brain , vol.62 , pp. 1
    • Holmes, G.1
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    • note
    • Supported by NSF dissertation improvement grant no. 0121930 (R.M.C.S.) and by NIH grant nos. NS302S6, NS40813, and NS17778. We thank S. Keele and S. Grafton for comments on this manuscript.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.