Evaluation of fusidic acid in therapy of experimental Staphylococcus aureus meningitis

Journal of Antimicrobial Chemotherapy

Volumn 51, Issue 5, 2003, Pages 1301-1305

  Østergaard, Christian ^a   Yieng Kow, Runa Vavia ^a   Knudsen, Jenny Dahl ^a   Frimodt Møller, Niels ^a   Espersen, Frank ^a  

^a STATENS SERUM INSTITUT   (Denmark)

Author keywords

Antagonism; Fusidic acid; Meningitis; Methicillin; Staphylococcus aureus

Indexed keywords

ANTIINFECTIVE AGENT; FUSIDIC ACID; GLUCOSE; INTERLEUKIN 8; LACTIC ACID; METICILLIN; PLASMA PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BACTERIAL MENINGITIS; BACTERICIDAL ACTIVITY; CEREBROSPINAL FLUID; CONTROLLED STUDY; DOSE RESPONSE; DRUG CEREBROSPINAL FLUID LEVEL; DRUG EFFICACY; EXPERIMENTAL MODEL; GLUCOSE BLOOD LEVEL; LACTATE BLOOD LEVEL; LEUKOCYTE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN BLOOD LEVEL; RABBIT; STAPHYLOCOCCUS AUREUS; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG THERAPY, COMBINATION; FUSIDIC ACID; GLUCOSE; INTERLEUKIN-8; LEUKOCYTE COUNT; MENINGITIS, BACTERIAL; METHICILLIN; MICROBIAL SENSITIVITY TESTS; PENICILLINS; RABBITS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 0038101648     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkg231     Document Type: Article

References (10)

1. Jensen, A. G., Espersen, F., Skinhøj, P., Rosdahl, V. T. & Frimodt-Møller, N. (1993). Staphylococcus aureus meningitis. A review of 104 nationwide, consecutive cases. Archives of Internal Medicine 153, 1902-8.
2. Collignon, P. & Turnidge, J. (1999). Fusidic acid in vitro activity. International Journal of Antimicrobial Agents 12, S45-58.
3. Turnidge, J. (1999). Fusidic acid pharmacology, pharmacokinetics and pharmacodynamics. International Journal of Antimicrobial Agents 12, S23-34.
4. Christiansen, K. (1999). Fusidic acid non-antibacterial activity. International Journal of Antimicrobial Agents 12, S73-8.
5. Østergaard, C., Benfield, T., Gesser, B., Kharazmi, A., Frimodt-Møller, N., Espersen, F. et al. (1999). Pretreatment with granulocyte colony-stimulating factor attenuates the inflammatory response but not the bacterial load in cerebrospinal fluid during experimental pneumococcal meningitis in rabbits. Infection and Immunity 67, 3430-6.
6. Lepper, M. H. & Dowling, H. F. (1951). Treatment of pneumococcic meningitis with penicillin compared with penicillin plus aureomycin. Archives of Internal Medicine 88, 489-94.
7. Fantin, B., Leclercq, R., Duval, J. & Carbon, C. (1993). Fusidic acid alone or in combination with vancomycin for therapy of experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 37, 2466-9.
8. Genovese, F., Mancuso, G., Cuzzola, M., Cusumano, V., Nicoletti, F., Bendtzen, K. et al. (1996). Improved survival and antagonistic effect of sodium fusidate on tumor necrosis factor alpha in a neonatal mouse model of endotoxin shock. Antimicrobial Agents and Chemotherapy 40, 1733-5.
9. Osman, M. O., ElSefi, T., Lausten, S. B., Jacobsen, N. O., Larsen, C. G. & Jensen, S. L. (1998). Sodium fusidate and the cytokine response in an experimental model of acute pancreatitis. British Journal of Surgery 85, 1487-92.
10. Mindermann, T., Zimmerli, W., Rajacic, Z. & Gratzl, O. (1993). Penetration of fusidic acid into human brain tissue and cerebrospinal fluid. Acta Neurochirurgica (Wien) 121, 12-4.