Changes in the refractive index of lens fibre membranes during maturation - Impact on lens transparency

Experimental Eye Research

Volumn 77, Issue 1, 2003, Pages 93-99

  Michael, Ralph ^a,b   Van Marle, Jan ^c   Vrensen, Gijs F J M ^d   Van Den Berg, Thomas J T P ^a  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b INSTITUT UNIVERSITARI BARRAQUER   (Spain)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cataractogenesis; Lens ultrastructure; Membrane structure; Refractive index; Transparency

Indexed keywords

BOVINE SERUM ALBUMIN; OIL;

ARTICLE; CYTOPLASM; DONOR; FREEZING; HUMAN; HUMAN TISSUE; LENS; LENS EPITHELIUM; LENS FIBER; LIGHT; LIGHT SCATTERING; MATURATION; PRIORITY JOURNAL; REFRACTION INDEX; REFRACTOMETRY;

EID: 0038095218     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4835(03)00065-4     Document Type: Article

References (40)

1. Alberts B., Bray D., Lewis J., Raff M., Roberts K., Watson J.D. Molecular Biology of the Cell. Molecular Biology of the Cell. 1994;Garland, New York. pp. 89-138.
2. Alberts B., Bray D., Lewis J., Raff M., Roberts K., Watson J.D. Molecular Biology of the Cell. Molecular Biology of the Cell. 1994;Garland, New York. pp. 477-495.
3. Al-Ghoul K.J., Costello M.J. Light microscopic variation of fibre cell size, shape and ordering in the equatorial plane of bovine and human lenses. Mol. Vis. 3:1997;2. http://www.molvis.org/molvis/v3/a2/.
4. Al-Ghoul K.J., Lane C.W., Taylor V.L., Fowler W.C., Costello M.J. Distribution and type of morphological damage in human nuclear age-related cataracts. Exp. Eye Res. 62:1996;237-251.
5. Al-Ghoul K.J., Nordgren R.K., Kuszak A.J., Freel C.D., Costello M.J., Kuszak J.R. Structural evidence of human nuclear fibre compaction as a function of ageing and cataractogenesis. Exp. Eye Res. 72:2001;199-214.
6. Babizhayev M.A., Costa E.B. Lipid peroxide and reactive oxygen species generating systems of the crystalline lens. Biochim. Biophys. Acta. 1225:1994;326-337.
7. Barer R. Phase contrast and interference microscopy in cytology. Pollister A.W. Physical Techniques in Biological Research. 1966;1-55 Academic Press, New York.
8. Barer R., Joseph S. Refractometry of living cells. Q. J. Microsc. Sci. 95:1954;399-423.
9. Benedek G.B. Cataract as a protein condensation disease. Invest. Ophthalmol. Vis. Sci. 38:1997;1911-1921.
10. van den Berg T. Light scattering by donor lenses as a function of depth and wavelength. Invest. Ophthalmol. Vis. Sci. 38:1997;1321-1332.
11. van den Berg T., Hagenouw M. Ciliary corona and lenticular halo. J. Cataract Refract. Surg. 27:2001;10-11.
12. van den Berg T., Spekreijse H. Light scattering model for donor lenses as a function of depth. Vision Res. 39:1999;1437-1445.
13. Bettelheim F.A. Physical basis of lens transparency. Maisel H. The Ocular Lens, Structure, Function and Pathology. 1985;265-295 Marcel Dekker, New York.
14. Bettelheim F.A., Wang T.J. Topographic distribution of refractive indices in bovine lenses. Exp. Eye Res. 18:1974;351-356.
15. Beuthan J., Minet O., Helfmann J., Herrig M., Muller G. The spatial variation of the refractive index in biological cells. Phys. Med. Biol. 41:1996;369-382.
16. Duindam J.J., Vrensen G.F., Otto C., Greve J. Aging affects the conformation of cholesterol in the human eye lens. Ophthalmic Res. 28:(Suppl. 1):1996;86-91.
17. Duindam H.J., Vrensen G.F., Otto C., Puppels G.J., Greve J. New approach to assess the cholesterol distribution in the eye lens: confocal Raman microspectroscopy and filipin cytochemistry. J. Lipid Res. 36:1995;1139-1146.
18. Fagerholm P.P., Philipson B.T., Lindström B. Normal human lens - the distribution of protein. Exp. Eye Res. 33:1981;615-620.
19. Gilliland K.O., Freel C.D., Lane C.W., Fowler W.C., Costello M.J. Multilamellar bodies as potential scattering centers in human age-related nuclear cataracts. Mol. Vis. 7:2001;120-130.
20. Greiner J.V., Auerbach D.B., Leahy C.D., Glonek T. Distribution of membrane phospholipids in the crystalline lens. Invest. Ophthalmol. Vis. Sci. 35:1994;3739-3746.
21. Gullstrand A. Die optische Abbildung in heterogenen Medien und die Dioptrik der Kristallinse des Menschen. 1908;Almqvist and Wiksell, Uppsala and Stockholm.
22. Hecht E. Optics. Optics. 1998;Addison-Wesley, Reading, MA. pp. 433-511.
23. Hemenger R.P. Small-angle intraocular light scatter: a hypothesis concerning its source. J. Opt. Soc. Am. [A]. 5:1988;577-582.
24. Hightower K.R., McCready J.P., Borchman D. Membrane damage in UV-irradiated lenses. Photochem. Photobiol. 59:1994;485-490.
25. Jacob R.F., Cenedella R.J., Mason R.P. Direct evidence for immiscible cholesterol domains in human ocular lens fibre cell plasma membranes. J. Biol. Chem. 274:1999;31613-31618.
26. Johnsen S., Widder E.A. The physical basis of transparency in biological tissue: ultrastructure and the minimization of light scattering. J. Theor. Biol. 199:1999;181-198.
27. Li L.K., So L., Spector A. Membrane cholesterol and phospholipid in consecutive concentric sections of human lenses. J. Lipid Res. 26:1985;600-609.
28. Philipson B. Distribution of protein within the normal rat lens. Invest. Ophthalmol. 8:1969;258-270.
29. Philipson B. Changes in the lens related to the reduction of transparency. Exp. Eye Res. 16:1973;29-39.
30. Roth E.H., Kluxen G. In-vivo-Messung der Brechungsindex-Verteilung der menschlichen Linse mit Hilfe eines Scheimpflug-Fotos des vorderen Augenabschnitts und einem Helium-Neon-Laserstrahl. Fortschritte der Ophthalmologie. 87:1990;312-316.
31. Salamon Z., Tollin G. Optical anisotropy in lipid bilayer membranes: coupled plasmon-waveguide resonance measurements of molecular orientation, polarizability, and shape. Biophys. J. 80:2001;1557-1567.
32. Siebinga I., Vrensen G.F., De Mul F.F., Greve J. Age-related changes in local water and protein content of human eye lenses measured by Raman microspectroscopy. Exp. Eye Res. 53:1991;233-239.
33. Simpson G.C. Ocular halos and coronas. Br. J. Ophthalmol. 37:1953;450-486.
34. Sivak J.G., Herbert K.L., Peterson K.L., Kuszak J.R. The interrelationship of lens anatomy and optical quality. I. Non-primate lenses. Exp. Eye Res. 59:1994;505-520.
35. Smith G., Pierscionek B.K. The optical structure of the lens and its contribution to the refractive status of the eye. Ophthalmic Physiol. Opt. 18:1998;21-29.
36. Taylor V.L., Al-Ghoul K.J., Lane C.W., Davis V.A., Kuszak J.R., Costello M.J. Morphology of the normal human lens. Invest. Ophthalmol. Vis. Sci. 37:1996;1396-1410.
37. Trokel S. The physical basis for transparency of the crystalline lens. Invest. Ophthalmol. 1:1962;493-501.
38. Vinciguerra M.J., Bettelheim F.A. Packing and orientation of fibre cells. Exp. Eye Res. 11:1971;214.
39. Vrensen G., Kappelhof J., Willekens B. Morphology of the aging human lens. II. Ultrastructure of clear lenses. Lens Eye Toxic. Res. 7:1990;1-30.
40. Zernike F. Phase contrast, a new method for the microscopic observation of transparent objects. Physica. 9:1942;686.