Porcine enamel matrix derivative enhances the formation of reparative dentine and dentine bridges during wound healing of amputated rat molars

Journal of Electron Microscopy

Volumn 52, Issue 2, 2003, Pages 227-236

  Igarashi, Rie ^a   Sahara, Takako ^a   Shimizu Ishiura, Miho ^a   Sasaki, Takahisa ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Dentine bridge; Enamel matrix derivative; Pulp amputation; Rat molars; Reparative dentine

Indexed keywords

ANIMALIA; RATTUS NORVEGICUS; SUIDAE; SUS SCROFA;

ARTIFICIAL LIMBS; BIOMINERALIZATION; BONE; ENAMELS;

BRIDGE-FORMATION; DENTIN WALL; DENTINE BRIDGE; ENAMEL MATRIX DERIVATIVES; MATRIX; PROPYLENE GLYCOL ALGINATES; PULP AMPUTATION; RAT MOLAR; REPARATIVE DENTINE; WOUND HEALING;

RATS;

EID: 0038083106     PISSN: 00220744     EISSN: None     Source Type: Journal    
DOI: 10.1093/jmicro/52.2.227     Document Type: Article

References (45)

1. Cox C F, Bergenholtz G, Fitzgerald M, Heys D R, Heys R J, Avary K, and Baker J A (1982) Capping of the dental pulp mechanically exposed to the oral microflora: a 5 week observation of wound healing in the monkey. J. Oral Pathol. 11: 327-339.
2. Cvek M, Granath L, Cleaton-Jones P, and Austin J (1987) Hard tissue barrier formation in pulpotomized monkey teeth capped with cyanoacrylate or calcium hydroxide for 10 and 60 minutes. J. Dent. Res. 66: 1166-1174.
3. Tziafas D, Smith A J, and Lesot H (2000) Designing new treatment strategies in vital pulp therapy. J. Dentistry 28: 77-92.
4. Smith A J and Lesot H (2001) Induction and regulation of crown dentinogenesis: embryonic events as a template for dental tissue repair? Crit. Rev. Oral Biol. Med. 12: 425-437.
5. Horsted P, El Attar K, and Langeland K (1981) Capping of monkey pulps with Dycal and Ca-eugenol cement. Oral Surg. 52: 531-533.
6. Sele U, Tamori I, Hirschfeld Z, and Bad I ( 1981 ) Transmission electron microscopy of reparative dentin in rat molar pulp. Acta Anat. 109: 247-251.
7. Cox C F and Bergenholtz G (1986) Healing sequence in capped inflamed dental pulps of Rhesus monkeys (Macaca mulatta). Int. Endodont. J. 19: 113-120.
8. Jaber L, Mascres C, and Donohue W B (1991) Electron microscope characteristics of dentin repair after hydroxy-apatite direct pulp capping in rats. J. Oral Med. 20: 502-508.
9. Mjor I A, Dahl E, and Cox C F (1991) Healing of pulp exposures: an ultrastructural study. J. Anat. 192: 400-406.
10. Yoshiba K, Yoshiba N, Nakamura H, Iwaku M, and Ozawa H (1996) Immunolocalization of fibronectin during reparative dentinogenesis in human teeth after pulp capping with calcium hydroxide. J. Dent. Res. 75: 1590-1597.
11. Nakashima M (1990) The induction of reparative dentine in the amputated dental pulp of the dog by bone morphogenetic protein. Archs. Oral Biol. 35: 493-497.
12. Nakashima M (1994) Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic proteins (BMP)-2 and 4. J. Dent. Res. 73: 1515-1522.
13. Rutherford R B, Wahle J, Tucker M, Rueger D, and Charette M (1993) Induction of reparative dentine formation in monkeys by recombinant human osteogenic protein-1. Archs. Oral Biol. 38: 571-576.
14. Hu J C C, Zhang C, Yun S S, Qian Q, and Ranly D D M (1997) Platelet-derived growth factor-BB and epidermal growth factor as pulp capping medicaments in rat incisors. J. Hard Tissue Biol. 6: 121-129.
15. Tziafas D, Alvanou A, Papadimitriou S, Gasic J, and Komnenou A (1998) Effects of recombinant basic fibroblast growth factor, insulin-like growth factor-II and transforming growth factor-β1 on dog dental pulp cells in vivo. Archs. Oral Biol. 43:431-441.
16. Rutherford R B and Gu K (2000) Treatment of inflamed ferret dental pulps with recombinant bone morphogenetic protein-7. Eur. J. Oral Sci. 108: 202-206.
17. Slavkin H C, Bessem C, Fincham A G, Bringas P, Bessem C, Snead L, and Zeichner-David M (1989) Human and mouse cementum proteins are immunologically related to enamel proteins. Biochem. Biophys. Acta 991: 12-18.
18. Fong D C, Slaby I, and Hammarstrom L (1996) Amelin, an enamel related protein, transcribed in the cells of epithelial root sheath. J. Bone Miner. Res. 11: 892-898.
19. Hammarstrom L (1997) Enamel matrix, cementum development and regeneration. J. Clin. Periodontol. 24: 658-668.
20. Hammarstrom L (1997) The role of enamel matrix proteins in the development of cementum and periodontal tissues. Ciba Found. Symp. 105 [Dental Enamel]: 246-260.
21. Hammarstrom L, Heijl L, and Gestrelius S (1997) Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J. Clin. Periodontol. 24: 669-677.
22. Heijl L (1997) Periodontal regeneration with enamel matrix derivative in one human experimental defect. J. Clin. Periodontol. 24: 693-696.
23. Heden G, Wennstrom J, and Lindhe J (1999) Periodontal tissue alternations following Emdogain treatment of periodontal sites with angular bone defects. J. Clin. Periodontol. 26: 855-860.
24. Pontoriero R, Wennstrom J, and Lindhe J (1999) The use of barrier membranes and enamel matrix proteins in the treatment of angular bone defects. J. Clin. Periodontol. 26: 833-840.
25. Mellonig J T (1999) Enamel matrix derivative for periodontal reconstructive surgery: technique and clinical and histologic case report. Int J. Periodont. Dent. 19: 9-19.
26. Sculean A, Donos N, Windisch P, Brecx M, Gera I, Reich E, and Karring T (1999) Healing of human intrabony defects following treatnrent with enamel matrix proteins or guided tissue regeneration. J. Periodont. Res. 34: 310-332.
27. Sculean A, Chiantella G C, Windisch P, and Donos N (2000) Clinical and histological evaluation of human intrabony defects treated with enamel matrix protein derivative (Emdogain). Int. J. Periodont. Rest. Dent. 20: 375-381.
28. Heard R H, Mellonig J T, Brunsvold M A, Lasho D J, Meffert R M, and Cochran D L (2000) Clinical evaluation of wound healing following multiple exposures to enamel matrix protein derivative in the treatment of intrabony periodontal defects. J. Periodontol. 71: 1715-1721.
29. Yukna R A and Mellonig J T (2000) Histological evaluation of periodontal healing in humans following regenerative therapy with enamel matrix derivative. J. Periodontol. 71: 752-759.
30. Kawana F, Sawae Y, Sahara T, Tanaka S, Debari K, Shimizu M, and Sasaki T (2001) Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur. Anat. Rec. 263: 127-138.
31. Shimizu-Ishiura M, Tanaka S, Lee W S, Debari K, and Sasaki T (2002) Effects of enamel matrix derivative to titanium implantation in rat femurs. J. Biomed. Mater. Res. 60: 269-276.
32. Nakamura Y, Hammarstrom L, Lundberg E, Ekdahl H, Matsumoto K, Gestrelius S, and Lyngstadaas S P (2001) Enamel matrix derivative promotes reparative processes in the dental pulp. Adv. Dent. Res. 15: 105-107.
33. Gladys S, van Meerbeek B, Bream M, Lambrechts P, and Vanherle G (1997) Comparative physico-chemical characterization of new hybrid restorative materials with conventional glass-ionomer and resin composite restorative materials. J. Dent. Res. 76: 883-894.
34. Schwartz Z, Carnes D L, Pulliam R, Lohmann C H, Sylvia V L, Liu Y, Dean D D, Cochran D L, and Boyan B D (2000) Porcine enamel matrix derivative stimulates proliferation but not differentiation of pre-oste-oblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells. J. Periodontol. 71: 1287-1296.
35. Tokiyasu Y, Takata T, Saygin E, and Somerman M (2000) Enamel factors regulate expression of genes associated with cementoblasts. J. Periodontol. 71: 1829-1839.
36. van der Pauw M T, van den Bos T, Everts V, and Beertsen W (2000) Enamel matrix-derived protein stimulates attachment of periodontal ligament fibroblasts and enhances alkaline phosphatase activity and transforming growth factor β1 release of periodontal ligament and gingival flbroblasts. J. Periodontol. 71: 31-43.
37. Lyngstadaas S P, Lundberg E, Ekdahl H, Andersson C, and Gestrelins S (2001) Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative. J. Clin. Periodontol. 28: 181-188.
38. Gestrelius S, Andersson C, Lidstrom D, Hammarstrom L, and Somerman M (1997) In vitro studies on periodontal ligament cells and enamel matrix derivative. J. Clin. Periodontol. 24: 685-692.
39. Cam Y, Neuman M R, and Ruch J V (1990) Immunolocalization of transforming growth factor and epidermal growth factor receptor epitopes in mouse incisors and molars with a demonstration of in vitro production of transforming activity. Archs. Oral Biol. 35: 813-822.
40. Cam Y, Lesot H, Colosetti P, and Ruch J V (1997) Distribution of transforming growth factor-β1-binding proteins and low-affinity epidermal receptors during odontoblast differentiation in the mouse. Archs. Oral Biol. 42: 385-391.
41. Vaahtokari A, Vainio S, and Thesleff I (1991) Associations between transforming growth factor-β1 RNA expression and epithelial-mesenchymal interactions during tooth morphogenesis. Development 113: 985-994.
42. Finkelman R D, Mohan S, Jennings J C, Taylor A K, Jepsen S, and Baylink D J (1990) Quantitation of growth factors IGF-I, SGF/IGF-II, and TGF-β in human dentin. J. Bone Miner. Res. 5: 717-723.
43. Cassidy N, Fahey M, Prime S S, and Smith A J (1997) Comparative analysis of transforming growth factor-β isoforms 1-3 in human and rabbit dentine matrices. Archs. Oral Biol. 42: 219-223.
44. Ross R (1987) Platelet-derived growth factor. Ann. Rev. Med. 38: 71-79.
45. Schroder U (1985) Effects of calcium hydroxide-containing pulp-capping agents on pulp cell migration, proliferation, and differentiation. J. Dent. Res. 64: 541-548.