Inosine and N1-methylinosine within a synthetic oligomer mimicking the anticodon loop of human tRNA(Ala) are major epitopes for anti-PL-12 myositis autoantibodies

RNA

Volumn 5, Issue 7, 1999, Pages 865-875

  Becker, H F ^a,b,c   Corda, Y ^a,b   Mathews, M B ^d   Fourrey, J L ^b   Grosjean, H ^a  

^a LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

^b CNRS   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Antigen; Autoantibodies; Epitope; Immunoprecipitation; Inosine; Myositis; N1 methylinosine; Phosphoramidite; tRNA

Indexed keywords

AUTOANTIBODY; INOSINE; TRANSFER RNA; 1 METHYLINOSINE; 1-METHYLINOSINE; ALANINE TRANSFER RNA; DNA; DRUG DERIVATIVE; EPITOPE; PHOSPHOLIPID ANTIBODY;

ANTICODON; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; HUMAN; IMMUNOPATHOGENESIS; MOLECULAR MIMICRY; MYOSITIS; PRIORITY JOURNAL; RNA STRUCTURE; STRUCTURE ANALYSIS; CHEMISTRY; CONFORMATION; IMMUNOLOGY; METHODOLOGY; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDE SEQUENCE; SERODIAGNOSIS; THIN LAYER CHROMATOGRAPHY;

ANTIBODIES, ANTIPHOSPHOLIPID; ANTICODON; BASE SEQUENCE; CHROMATOGRAPHY, THIN LAYER; DNA; EPITOPES; HUMANS; INOSINE; MOLECULAR MIMICRY; MYOSITIS; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HYBRIDIZATION; PRECIPITIN TESTS; RNA, TRANSFER, ALA;

EID: 0032588113     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838299990118     Document Type: Article

References (61)

1. Auxilien S, Crain PF, Trewyn RW, Grosjean H. 1996. Mechanism, specificity and general properties of the yeast enzyme catalyzing the formation of inosine 34 in the anticodon of transfer RNA. J Mol Biol 262:437-458.
2. Becker HF, Grosjean H, Fourrey J.-L. 1998. Chemical synthesis of 4-thiouridine-containing substrate analogues of tRNA:pseudouridine-55 synthase: Photocross-linking studies. Nucleotides & Nucleosides 17:2403-2416.
3. Björk GR. 1998. Modified nucleosides at positions 34 and 37 of tRNAs and their predicted coding capacities. In: Grosjean H, Benne R, eds. Modification and editing of RNA. Washington, DC: American Society of Microbiology Press. pp 577-581.
4. Boulanger C, Chabot B, Ménard HA, Boire G. 1995. Autoantibodies in human anti-Ro sera specifically recognize deproteinized hY5 Ro RNA. Clin Exp Immunol 99:29-36.
5. Braun RP, Woodsworth ML, Lee JS. 1986. The immunogenic properties of poly(dl).poly(dC) and poly (rl).poly (dC): Analysis of monoclonal antibodies. Mol Immunol 23:685-691.
6. Bredereck H, Martini A. 1947. Uber methylierte nucleoside und purine und ihre pharmakolischen wirkungen I. Methylierung von nucleosiden durch diazomethan. Chem Ber 80:401-405.
7. Brouwer R, Vree Egberts W, Jongen PH, van Engelen BG, van Venrooij WJ. 1998. Frequent occurrence of anti-tRNA(His) autoantibodies that recognize a conformational epitope in sera of patients with myositis. Arthritis Rheum 41:1428-1437.
8. Bunn CC, Bernstein RM, Mathews MB. 1986. Autoantibodies against alanyl-tRNA synthetase and tRNA(Ala) coexist and are associated with myositis. J Exp Med 163:1281-1291.
9. Bunn CC, Mathews MB. 1987a. Autoreactive epitope defined as the anticodon region of alanine transfer RNA. Science 238:1116-1119.
10. Bunn CC, Mathews MB. 1987b. Two human tRNA(Ala) families are recognized by autoantibodies in polymyositis sera. Mol Biol Med 4:21-36.
11. Chu J-L, Brot N, Weissbach H, Elkon K. 1991. Lupus antiribosomal P antisera contain antibodies to a small fragment of 28S rRNA located in the proposed ribosomal GTPase center. J Exp Med 174:507-514.
12. Corda Y, Grosjean H. 1995. Characterization of the epitopes of myositis-specific autoantibodies directed against human tRNA(Ala): An enzymatic approach. Arch Physiol Biochem 103: B74.
13. Crain PF, McCloskey JA. 1997. The RNA modification database. Nucleic Acids Res 25:126-127.
14. D'Ambrosio SM, Gibson DARE, Trewyn RW. 1991. An enzyme-linked immunosorbent assay (ELISA) for the detection and quantitation of the tumor marker 1-methylinosine in human urine. Clin Chim Acta 199:119-128.
15. Damha MJ, Ogilvie KK. 1993. Oligoribonucleotide synthesis. The silyl-phosphoramidite method. Methods Mol Biol 20:81-114.
16. Deutscher SL, Keene JD. 1988. A sequence-specific conformational epitope on U1 RNA is recognized by a unique autoantibody. Proc Natl Acad Sci USA 85:3299-3303.
17. England TE, Bruce AG, Uhlenbeck OC. 1980. Specific labeling of 3′-termini of RNA with T4 RNA ligase. Methods Enzymol 65: 65-74.
18. Fuchs S, Aharonov A, Sela M, Von der Haar F, Cramer F. 1974. Antibodies to yeast phenylalanine tRNA are specific for the odd nucleoside "Y" in the anticodon loop. Proc Natl Acad Sci USA 71:2800-2802.
19. Gait MJ, Pritchard C, Slim G. 1991. Oligonucleotides and analogues: A practical approach. In: Eckstein F, ed. Oligonucleotides and analogues: A practical approach. Oxford, UK: IRL Press. pp 25-48.
20. Garcia-Lozano JR, Gonzalez-Escribano MF, Rodriguez R, Rodriguez-Sanchez JL, Targoff IN, Wichmann I, Nunez-Roldan A. 1998. Detection of anti-PL-12 autoantibodies by ELISA using a recombinant antigen; study of the immunoreactive region. Clin Exp Immunol 114:161-165.
21. Gasparutto D, Livache T, Bazin H, Duplaa AM, Guy A, Khorlin A, Molko D, Roget A, Teoule R. 1992. Chemical synthesis of a biologically active natural tRNA with its minor bases. Nucleic Acids Res 20:5159-5166.
22. Gelpi C, Kanterewicz E, Gratacos J, Targoff IN, Rodriguez-Sanchez JL. 1996. Coexistence of two antisynthetases in a patient with the antisynthetase syndrome. Arthritis Rheum 39:692-697.
23. Gerber A, Grosjean H, Melcher T, Keller W. 1998. Tad1p, a yeast specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR-1 and ADAR-2. EMBO J 17:4780-4789.
24. Green R, Szostak JW, Benner SA, Rich A, Usman N. 1991. Synthesis of RNA containing inosine: Analysis of the sequence requirements for the 5′ splice site of the tetrahymena group I intron. Nucleic Acids Res 19:4161-166.
25. 1-methylinosine in transfer RNAs: A review. Biochimie 78:488-501.
26. Grosjean H, Motorin Y, Morin A. 1998. RNA-modifying and RNA-editing enzymes: Methods for their identification. In: Grosjean H, Benne R, eds. Modification and editing of RNA. Washington, DC: ASM Press. pp 21-46.
27. Hirakata M, Suwa A, Nagai S, Kron MA, Trieu EP, Mimori T, Akizuki M, Targoff IN. 1999. Anti-KS: Identification of autoantibodies to Asparaginyl-tRNA synthetase associated with intestinal lung disease. J Immunol 162:2315-2320.
28. Hoet RM, Van Venrooij WJ. 1992. B-cell epitopes of RNA autoantigens. Mol Biol Rep 16:199-205.
29. Inouye H, Fuchs S, Sela M, Littauer UZ. 1971. Anti-inosine antibodies. Biochem Biophys Acta 240:594-603.
30. Kato T, Sasakawa H, Suzuki S, Shirako M, Toshiro F, Nishioka K, Yamamoto K. 1995. Autoepitopes of the 52 kD SSA/Ro molecule. Arthritis Rheum 38:990-998.
31. Keene JD. 1996. RNA surfaces as functional mimetics of proteins. Chem Biol 3:505-513.
32. Keith G. 1995. Mobilities of modified ribonucleotides on two-dimensional cellulose thin-layer chromatography. Biochimie 77:142-144.
33. Mathews MB, Reichlin M, Hughes GR, Bernstein RM. 1984. Anti-threonyl-tRNA synthetase, a second myositis-related autoantibody. J Exp Med 160:420-434.
34. Matsumura M, Ohosone Y, Miyachi K, Akizuki A, Matsuoka Y, Irimajiri S, Shimizu M, Mimori T. 1996. Novel autoantibodies directed against the common tertiary configuration of transfer RNA in a patient with interstitial lung disease. Arthritis Rheum 39:1308-1312.
35. Miles HT. 1961. The preparation and characterization of 1-methylinosine. J Org Chem 26:4761-4762.
36. Mimori T. 1996. Structures targeted by the immune system in myositis. Curr Opin Rheumatol 8:521-527.
37. Nishikai M, Reichlin M. 1980. Heterogeneity of precipitating antibodies in polymyositis and dermatomyositis. Characterization of the JO-1 antibody system. Arthritis Rheum 23:881-888.
38. Ohosone Y, Matsumura M, Chiba J, Nagaoka S, Matsuoka Y, Irimajiri S, Mimori T. 1998. Anti-transfer RNA antibodies in two patients with pulmonary fibrosis, Raynaud's phenomenon and polyarthritis. Clin Rheumatol 17:144-147.
39. Ohtsuka E, Matsuki S, Ikehara M, Takahashi Y, Matsubara K. 1985. An alternative approach to deoxyoligonucleotides as hybridization probes by insertion of deoxyinosine at ambiguous codon positions. J Biol Chem 260:2605-2608.
40. Okano Y, Medsger TA. 1992. Novel human autoantibodies reactive with 5′-terminal trimethylguanosine CAP structures of U small nuclear RNA. J Immunol 149:1093-1098.
41. Paley EL, Alexandrova N, Smelansky L. 1995. Tryptophanyl-tRNA synthetase as a human autoantigen. Immunol Lett 48:201-207.
42. Plotz PH, Rider LG, Targoff IN, Raben N, O'Hanlon TP, Miller FW. 1995. Myositis: Immunologic contributions to understanding cause, pathogenesis, and therapy. Ann Intern Med 122:715-724.
43. Pokkuluri PR, Bouthillier F, Li Y, Kuderova A, Lee J, Cygler M. 1994. Preparation, characterization and crystallization of an antibody Fab fragment that recognizes RNA. J Mol Biol 243:283-297.
44. Raben N, Nichols R, Dohlman J, McPhie P, Sridhar S, Hyde C, Leff R, Plotz P. 1994. A motif in human histidyl-tRNA synthetase which is shared among several aminoacyl-tRNA synthetases is a coiled-coil that is essential for enzymatic activity and contains the major autoantigenic epitope. J Biol Chem 269:24277-24283.
45. Ramsden DA, Chen J, Miller FW, Misener V, Bernstein RM, Siminovitch KA, Tsui FWL. 1989. Epitope mapping of the cloned human autoantigen, histidyl-tRNA synthetase. J Biol Chem 143:2267-2272.
46. Renaud C, Bruno C, Boullanger P, Grange J, Barbesti S, Niveleau A. 1991. Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies. Cancer Lett 61:255-262.
47. Ripmaster TL, Shiba K, Schimmel P. 1995. Wide cross-species aminoacyl-tRNA synthetase replacement in vivo: Yeast cytoplasmic alanine enzyme replaced by human polymyositis serum antigen. Proc Natl Acad Sci USA 92:4932-4936.
48. Rutjes SA, Vree Egberts WTM, Jongen P, Van Den Hoogen F, Pruijn GJM, Van Venrooij WJ. 1997. Anti-Ro52 antibodies frequently co-occur with anti-Jo-1 antibodies in sera from patients with idiopathic inflammatory myopathy. Clin Exp Immunol 109:32-40.
49. Scheit KH, Holy A. 1967. Die methylierung von inosin und urydyl-(3′-5′)inosin durch dimethylsulfat. Biochim Biophys Acta 140:344-354.
50. 32P]-labeling in the sequence analysis of non radioactive tRNAs. Methods Enzymol 59:58-109.
51. Sprague KU, Hagenbuechle O, Zuniga MC. 1977. The nucleotide sequence of two silk gland alanine tRNAs: Implications for fibroin synthesis and for initiator tRNA structure. Cell 11:561-570.
52. Sprinzl S, Horn C, Brown M, Ioudovitch A, Steinberg S. 1998. Compilation of tRNA sequences and sequences of tRNA genes. Nucleic Acids Res 26:148-153.
53. Targoff IN. 1992. Autoantibodies in polymyositis. Rheum Dis Clin North Am 18:455-482.
54. Targoff IN. 1994. Immune manifestations of inflammatory muscle disease. Rheum Dis Clin North Am 20:857-880.
55. Teunissen SWM, Stassen MHW, Pruijn GJM, Van Venrooij WJ. 1998. Characterization of an anti-RNA recombinant autoantibody fragment (scFv) isolated from a phage display library and detailed analysis of its binding site on U1 snRNA. RNA 4:1124-1133.
56. Tsai DE, Kenan DJ, Keene JD. 1992. In vitro selection of an RNA epitope immunologically cross-reactive with a peptide. Proc Natl Acad Sci USA 89:8864-8868.
57. Vazquez-Abad D, Rothfield NF. 1996. Sensitivity and specificity of anti-Jo-1 antibodies in autoimmune diseases with myositis. Arthritis Rheum 39:292-296.
58. Void BS. 1990. Immunoassays for modified nucleosides of ribonucleic acids. In: Gehrke CW, Kuo KCT, eds. Chromatography and modification of nucleosides. Part A: Analytical methods for major and modified nucleosides. Vol. 45A. Amsterdam: Elsevier. pp 317-344.
59. Westhof E, Dumas P, Moras D. 1988. Restrained refinement of two crystalline forms of yeast aspartic acid and phenylalanine transfer RNA crystals. Acta Crystallogr A 44:112-123.
60. Xue H, Glasser AL, Desgres J, Grosjean H. 1993. Modified nucleotides in Bacillus subtilis tRNA(Trp) hyperexpressed in Escherichia coli. Nucleic Acids Res 21:2479-2486.
61. Yamauchi K, Nakamura K, Kinoshita M. 1978. Methylation of pyrimidines, the corresponding nucleosides, and inosine with trimethyloxosulfonium hydroxide. J Org Chem 43:1593-1595.