Hoxb13 is required for normal differentiation and secretory function of the ventral prostate

Development

Volumn 130, Issue 10, 2003, Pages 2061-2069

  Economides, Kyriakos D ^a,b   Capecchi, Mario R ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Hox genes; Hoxb13; Mouse; Prostate; Secretory proteins

Indexed keywords

ANDROGEN RECEPTOR; BINDING PROTEIN; HOX PROTEIN; PROTEIN HOXB13; PROTEIN P25; PROTEINASE INHIBITOR; SECRETORY PROTEIN; SPERMINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; CELL STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION; GONAD DEVELOPMENT; HOMOZYGOSITY; HOX GENE; HYPOPLASIA; IMMUNOFLUORESCENCE; MORPHOGENESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROSTATE; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; EPITHELIAL CELLS; HOMEODOMAIN PROTEINS; HUMANS; MALE; MICE; MUTATION; PHENOTYPE; PROSTATE; PROSTATIC SECRETORY PROTEINS; TRANSCRIPTION FACTORS;

ANIMALIA; MURINAE;

EID: 0038074197     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.00432     Document Type: Review

References (58)

1. Abate-Shen, C. and Shen, M. M. (2000). Molecular genetics of prostate cancer. Genes Dev. 14, 2410-2434.
2. Abdulkadir, S. A., Magee, J. A., Peters, T. J., Kaleem, Z., Naughton, C. K., Humphrey, P. A. and Milbrandt, J. (2002). Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol. Cell. Biol. 22, 1495-1503.
3. Bhatia-Gaur, R., Donjacour, A. A., Sciavolino, P. J., Kim, M., Desai, N., Young, P., Norton, C. R., Gridley, T., Cardiff, R. D., Cunha, G. R. et al. (1999). Roles for Nkx3.1 in prostate development and cancer. Genes Dev. 13, 966-977.
4. Bieberich, C. J., Fujita, K., He, W. W. and Jay, G. (1996). Prostate-specific and androgen-dependent expression of a novel homeobox gene. J. Biol. Chem. 271, 31779-31782.
5. Bradshaw, B. S. and Wolfe, H. G. (1977). Coagulation proteins in the seminal vesicle and coagulating gland of the mouse. Biol. Reprod. 16, 292-297.
6. Brothman, A. R. (1997). Cytogenetic studies in prostate cancer: are we making progress? Cancer Genet Cytogenet. 95, 116-121.
7. Brothman, A. R., Steele, M. R., Williams, B. J., Jones, E., Odelberg, S., Albertsen, H. M., Jorde, L. B., Rohr, L. R. and Stephenson, R. A. (1995). Loss of chromosome 17 loci in prostate cancer detected by polymerase chain reaction quantitation of allelic markers. Genes Chromosomes Cancer 13, 278-284.
8. Chen, F. and Capecchi, M. R. (1999). Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Proc. Natl. Acad. Sci. USA 96, 541-546.
9. Chen, L. Y., Lin, Y. H., Lai, M. L. and Chen, Y. H. (1998). Developmental profile of a caltrin-like protease inhibitor, P12, in mouse seminal vesicle and characterization of its binding sites on sperm surface. Biol. Reprod. 59, 1498-1505.
10. Chisaka, O., Musci, T. S. and Capecchi, M. R. (1992). Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6. Nature 355, 516-520.
11. Cohen-Tannoudji, M., Vandormael-Pournin, S., Drezen, J., Mercier, P., Babinet, C. and Morello, D. (2000). lacZ sequences prevent regulated expression of housekeeping genes. Mech. Dev. 90, 29-39.
12. Davis, A. P. and Capecchi, M. R. (1994). Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. Development 120, 2187-2198.
13. Davis, A. P., Witte, D. P., Hsieh-Li, H. M., Potter, S. S. and Capecchi, M. R. (1995). Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 375, 791-795.
14. de Groot, N., van Kuik-Romeijn, P., Lee, S. H. and de Boer, H. A. (1999). Over-expression of the murine polymeric immunoglobulin receptor gene in the mammary gland of transgenic mice. Transgenic Res. 8, 125-135.
15. Deubler, D. A., Williams, B. J., Zhu, X. L., Steele, M. R., Rohr, L. R., Jensen, J. C., Stephenson, R. A., Changus, J. E., Miller, G. J., Becich, M. J. et al. (1997). Allelic loss detected on chromosomes 8, 10, and 17 by fluorescence in situ hybridization using single-copy P1 probes on isolated nuclei from paraffin-embedded prostate tumors. Am. J. Pathol. 150, 841-850.
16. Dlouhy, S. R. and Karn, R. C. (1984). Multiple gene action determining a mouse salivary protein phenotype: identification of the structural gene for androgen binding protein (Abp). Biochem. Genet. 22, 657-667.
17. Dlouhy, S. R., Taylor, B. A. and Karn, R. C. (1987). The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located on chromosome 7. Genetics 115, 535-543.
18. Dolle, P., Dierich, A., LeMeur, M., Schimmang, T., Schuhbaur, B., Chambon, P. and Duboule, D. (1993). Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75, 431-441.
19. Donjacour, A. A., Rosales, A., Higgins, S. J. and Cunha, G. R. (1990). Characterization of antibodies to androgen-dependent secretory proteins of the mouse dorsolateral prostate. Endocrinology, 126, 1343-1354.
20. Duboule, D. (1995). Vertebrate Hox genes and proliferation: an alternative pathway to homeosis? Curr. Opin. Genet. Dev. 5, 525-528.
21. Economides, K. D., Zeltser, L. and Capecchi, M. R. (2003). Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae. Dev. Biol. (in press).
22. Garcia-Gasca, A. and Spyropoulos, D. D. (2000). Differential mammary morphogenesis along the anteroposterior axis in Hoxc6 gene targeted mice. Dev. Dyn. 219, 261-276.
23. Greer, J. M. and Capecchi, M. R. (2002). Hoxb8 is required for normal grooming behavior in mice. Neuron 33, 23-34.
24. Kaetzel, C. S. (2001). Polymeric Ig receptor: defender of the fort or Trojan horse? Curr. Biol. 11, R35-38.
25. Kaetzel, C. S., Robinson, J. K., Chintalacharuvu, K. R., Vaerman, J. P. and Lamm, M. E. (1991). The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA. Proc. Natl. Acad. Sci. USA 88, 8796-8800.
26. Karn, R. C. and Russell, R. (1993). The amino acid sequence of the alpha subunit of mouse salivary androgen-binding protein (ABP), with a comparison to the partial sequence of the beta subunit and to other ligand-binding proteins. Biochem. Genet. 31, 307-319.
27. Kaushic, C., Richardson, J. M. and Wira, C. R. (1995). Regulation of polymeric immunoglobulin A receptor messenger ribonucleic acid expression in rodent uteri: effect of sex hormones. Endocrinology 136, 2836-2844.
28. Kaushic, C., Frauendorf, E. and Wira, C. R. (1997). Polymeric immunoglobulin A receptor in the rodent female reproductive tract: influence of estradiol in the vagina and differential expression of messenger ribonucleic acid during estrous cycle. Biol. Reprod. 57, 958-966.
29. Kim, M. J., Cardiff, R. D., Desai, N., Banach-Petrosky, W. A., Parsons, R., Shen, M. M. and Abate-Shen, C. (2002). Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Proc. Natl. Acad. Sci. USA 99, 2884-2889.
30. Kondo, T., Zakany, J., Innis, J. W. and Duboule, D. (1997). Of fingers, toes and penises. Nature 390, 29.
31. Krumlauf, R. (1994). Hox genes in vertebrate development. Cell 78, 191-201.
32. Lagorce-Pages, C., Paraf, F., Dubois, S., Belghiti, J. and Flejou, J. F. (1998). Expression of CD44 in premalignant and malignant Barrett's oesophagus. Histopathology 32, 7-14.
33. Lamm, M. E., Mazaneca, M. B., Nedrud, J. G. and Kaetzel, C. S. (1995). New functions for mucosal IgA. Adv. Exp. Med. Biol. 371A, 647-650.
34. Maccioni, M., Riera, C. M. and Rivero, V. E. (2001). Identification of rat prostatic steroid binding protein (PSBP) as an immunosuppressive factor. J Reprod. Immunol. 50, 133-149.
35. Mansour, S. L., Goddard, J. M. and Capecchi, M. R. (1993). Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development 117, 13-28.
36. Mills, J. S., Needham, M. and Parker, M. G. (1987a). A secretory protease inhibitor requires androgens for its expression in male sex accessory tissues but is expressed constitutively in pancreas. EMBO J. 6, 3711-3717.
37. Mills, J. S., Needham, M. and Parker, M. G. (1987b). Androgen regulated expression of a spermine binding protein gene in mouse ventral prostate. Nucleic Acids Res. 15, 7709-7724.
38. Mills, J. S., Needham, M., Thompson, T. C. and Parker, M. G. (1987c). Androgen-regulated expression of secretory protein synthesis in mouse ventral prostate. Mol. Cell Endocrinol. 53, 111-118.
39. Mirosevich, J., Bentel, J. M., Zeps, N., Redmond, S. L., D'Antuono, M. F. and Dawkins, H. J. (1999). Androgen receptor expression of proliferating basal and luminal cells in adult murine ventral prostate. J. Endocrinol. 162, 341-350.
40. Mirosevich, J., Bentel, J. M. and Dawkins, J. S. (2001). Regulation of caltrin mRNA expression by androgens in the murine prostate. J. Androl. 22. 449-457.
41. Mostov, K. E. (1994). Transepithelial transport of immunoglobulins. Annu. Rev. Immunol. 12, 63-84.
42. Paradis, V., Eschwege, P., Loric, S., Dumas, F., Ba, N., Benoit, G., Jardin, A. and Bedossa, P. (1998). De novo expression of CD44 in prostate carcinoma is correlated with systemic dissemination of prostate cancer. J. Clin. Pathol. 51, 798-802.
43. Patterson, L. T., Pembaur, M. and Potter, S. S. (2001). Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney. Development 128, 2153-2161.
44. Podlasek, C. A., Duboule, D. and Bushman, W. (1997). Male accessory sex organ morphogenesis is altered by loss of function of Hoxd-13. Dev. Dyn. 208, 454-465.
45. Podlasek, C. A., Clemens, J. Q. and Bushman, W. (1999). Hoxa-13 gene mutation results in abnormal seminal vesicle and prostate development. J. Urol. 161, 1655-1661.
46. Prinsac, G. S., Birch, L., Habermann, H., Chang, W. Y., Tebeau, C., Putz, O. and Bieberich, C. (2001). Influence of neonatal estrogens on rat prostate development. Reprod. Fertil. Dev. 13, 241-252.
47. Richardson, J. M., Kaushic, C. and Wira, C. R. (1995). Polymeric immunoglobin (Ig) receptor production and IgA transcytosis in polarized primary cultures of mature rat uterine epithelial cells. Biol. Reprod. 53, 488-498.
48. Schwenk, F., Baron, U. and Rajewsky, K. (1995). A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23, 5080-5081.
49. Sciavolino, P. J., Abrams, E. W., Yang, L., Austenberg, L. P., Shen, M. M. and Abate-Shen, C. (1997). Tissue-specific expression of murine Nkx3.1 in the male urogenital system. Dev. Dyn. 209, 127-138.
50. Sreenath, T., Orosz, A., Fujita, K. and Bieberich, C. J. (1999). Androgen-independent expression of hoxb-13 in the mouse prostate. Prostate 41, 203-207.
51. Sugar, J., Vereczkey, I., Toth, J., Peter, I. and Banhidy, F. (1997). New aspects in the pathology of the preneoplastic lesions of the larynx. Acta Otolaryngol. Suppl. 527, 52-56.
52. Sugimura, Y., Cunha, G. R. and Donjacour, A. A. (1986). Morphogenesis of ductal networks in the mouse prostate. Biol. Reprod. 34, 961-971.
53. Takeda, H., Suematsu, N. and Mizuno, T. (1990). Transcription of prostatic steroid binding protein (PSBP) gene is induced by epithelial-mesenchymal interaction. Development 110, 273-281.
54. Thorey, I. S., Meneses, J. J., Neznanov, N., Kulesh, D. A., Pedersen, R. A. and Oshima, R. G. (1993). Embryonic expression of human keratin 18 and K18-beta-galactosidase fusion genes in transgenic mice. Dev. Biol. 160, 519-534.
55. Warot, X., Fromental-Ramain, C., Fraulob, V., Chambon, P. and Dolle, P. (1997). Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts. Development 124, 4781-4791.
56. Wellik, D. M., Hawkes, P. J. and Capecchi, M. R. (2002). Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev. 16, 1423-1432.
57. Wimmel, A., Kogan, E., Ramaswamy, A. and Schuermann, M. (2001). Variant expression of CD44 in preneoplastic lesions of the lung. Cancer 92, 1231-1236.
58. Zeltser, L., Desplan, C. and Heintz, N. (1996). Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. Development 122, 2475-2484.