A phase I/II study of CHARTWEL with concurrent chemotherapy in locally advanced, inoperable carcinoma of the oesophagus

Clinical Oncology

Volumn 15, Issue 3, 2003, Pages 109-114

  Harney, J ^a   Goodchild, K ^a   Phillips, H ^a   Glynne Jones, R ^a   Hoskin, P J ^a   Saunders, M I ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

CHARTWEL accelerated hyperfractionation; Chemoradiation; Oesophageal cancer

Indexed keywords

ANALGESIC AGENT; CISPLATIN; FLUOROURACIL; OPIATE;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; DYSPHAGIA; ESOPHAGITIS; ESOPHAGUS BIOPSY; ESOPHAGUS CARCINOMA; ESOPHAGUS STRICTURE; FEMALE; HUMAN; INOPERABLE CANCER; MALE; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DOSE FRACTIONATION; SURVIVAL RATE; SURVIVAL TIME;

EID: 0038069201     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1053/clon.2003.0200     Document Type: Article

References (37)

1. CancerStats - Mortality U.K. Cancer Research U.K., June 2002.
2. Flores AD. Cancer of the oesophagus and cardia: overview of radiotherapy. Can J Surg 1989;32:404-409.
3. Minsky BD. Nonsurgical treatment approaches for oesophageal cancer. In: Perry M, ed. American Society of Clinical Oncology Educational Book. New York: American Society of Clinical Oncology, 1997;164-174.
4. Earlam R. An MRC prospective randomised trial of radiotherapy versus surgery for inoperable squamous cell carcinoma of the oesophagus. Ann R Coll Surg Engl 1995;73:8-12.
5. Earlam R, Cunha-Melo JR. A critical view of radiotherapy. Br J Surg 1980;67:457-461.
6. Earlam R, Cunha-Melo JR. A critical overview of surgery. Br J Surg 1980;67:381-390.
7. Smith TJ, Ryan LM, Douglas HO, et al. Combined chemoradiotherapy versus radiotherapy alone for early stage squamous cell carcinoma of the oesophagus: a study of the Eastern Co-operative Oncology Group. Int J Radiat Oncol Biol Phys 1998;42:269-276.
8. Roussel A, Haegele P, Paillot B, et al. Results of the EORTC-GTCCG phase 111 trial of irradiation versus irradiation and CDDP in inoperable oesophageal cancer. Proc Ann Meet Soc Clin Oncol 1994;13:A583.
9. Al-Sarraf M, Matz K, Herskovic A, et al. Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with oesophageal cancer: an Intergroup Study. J Clin Oncol 1997;15:277-284.
10. Cooper JS, Gio MD, Herskovic A, et al. Chemoradiotherapy of locally advanced oesophageal cancer. Long term follow-up of a prospective randomised trial (RTOG 85-01). JAMA 1999;281:1623-1627.
11. Wong R, Malthaner R. Combined chemotherapy and radiotherapy (without surgery) compared radiotherapy alone in localised carcinoma of the oesophagus (Cochrane Review). In: The Cochrane Library, Issue 4, 2002. Oxford: Update Software.
12. Saunders MC, Dische D, Barrett A. Continuous, hyperfractionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multi-center trial. Radiother Oncol 1999;52:137-148.
13. Dische S, Saunders MC, Barrett A, et al. A randomised multicenter trial of CHART versus conventional radiotherapy in head and neck cancer. Radiother Oncol 1997;44:123-136.
14. Laing JHE, Rew DA, Wilson GD. Cell kinetics of human solid tumours. Br J Radiol 1993;24(Suppl.): 163-167.
15. Nishimura Y, Ono K, Tsutsui N, et al. Oesophageal cancer treated with radiotherapy. Impact of total treatment time and fractionation. Int J Radiat Oncol Biol Phys 1994;30:1099-1105.
16. De Paoli A, Boz G, Trovo MG, et al. Multiple fraction per day radiation therapy for inoperable oesophageal cancer. Int J Radiat Oncol Biol Phys 1998;19:61-67.
17. Kikuchi Y. Study on clinical application of multiple fractions per day radiation therapy with concomitant boost technique for oesophageal cancer. Hokkaido Igaku Zasshi 1993;68:537-556.
18. Powell MEB, Hoskin PJ, Saunders MI, et al. Continuous, hyperfractionated, accelerated radiotherapy (CHART) in localised cancer of the oesophagus. Int J Radiat Oncol Biol Phys 1997;38:133-136.
19. Jeremic B, Shibamoto Y, Acimovic L, et al. Accelerated, hyperfractionated radiation therapy and concurrent 5-FU/Cisplatin chemotherapy for loco-regional squamous cell carcinoma of the thoracic oesophagus. Int J Radiat Oncol Biol Phys 1998;40:1061-1066.
20. Chidel MA, Rice TW, Adelstein DG, et al. Resectable oesophageal carcinoma: local control with neoadjuvant chemotherapy and radiation therapy. Radiology 1999;213:67-72.
21. LePrise EA, Etienne PL, Meunier BC, et al. A randomised study of chemotherapy, radiation therapy and surgery versus surgery alone for localised squamous cell carcinoma of the oesophagus. Cancer 1994;73:1779-1784.
22. Walsh TN, Noonan N, Hollywood D, et al. A Comparison of multimodal therapy and surgery for oesophageal cancer. N Engl J Med 1996;335:462-467.
23. Bosset JF, Gigroux M, Triboulet JP, et al. Chemoradiotherapy followed by surgery compared with surgery alone in squamous cell cancer of the oesophagus. N Engl J Med 1997;337:161-167.
24. Coia LR, Engstrom PF, Paul AR, et al. Long term infusional 5-FU, mitomycin-C and radiation as primary management of oesophageal carcinoma. Int J Radiat Oncol Biol Phys 1991;20:29-36.
25. Sur RJ, Levin CV, Donde B, et al. Prospective randomised trial of HDR brachytherapy as a sole modality in palliation of advanced oesophageal carcinoma - an International Atomic Energy Study. Int J Radiat Oncol Biol Phys 2002;53:127-133.
26. Dische S, Warburten MF, Jones D, Lartigau E. The recording of morbidity related to radiotherapy. Radiother Oncol 1989;16:103-108.
27. Kaplan HS, Meier P. Non-parametric estimations from incomplete observations. Am Stat Assoc J 1958;53:457-480.
28. Ohtsu A, Boku N, Muro K, et al. Definitive chemoradiotherapy for T4 and/or M1 lymph node squamous cell carcinoma of the oesophagus. J Clin Oncol 1999;17:2915-2921.
29. Wobbes T, Baron B, Paillot B, et al. Prospective randomised study of split course radiotherapy versus cisplatin plus split course radiotherapy in inoperable squamous cell carcinoma of the oesophagus. Eur J Cancer 2001;37:470-477.
30. Tannock IF. Treatment of cancer with radiation and drugs. J Clin Oncol 1996;14:3156-3174.
31. Locich JJ, Ahlgren JD, Gullo JJ, et al. A prospective randomised comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colo-rectal carcinoma: a Mid-Atlantic Oncology Program Study. J Clin Oncol 1989;7:425-432.
32. Thomas GM. Improved treatment for cervical cancer - concurrent chemotherapy and radiotherapy. N Engl J Med 1999;340:1198-1199.
33. Rose PC, Bundy BN, Watkins EB, et al. Concurrent cisplatin based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 1999;340:1144-1153.
34. Schaake-Koning C, van de Boogaert W, Dalesio O, et al. Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer. N Engl J Med 1992;326:524-530.
35. Nishimura Y, Suzuki M, Nakamatsu K, et al. Prospective trial of concurrent chemoradiotherapy with protracted infusion of 5-Fluorouracil and cisplatin for T4 oesophageal cancer with or without fistula. Int J Radiat Oncol Biol Phys 2002;53:134-139.
36. Beatty JD, De Boer G, Rider WD, et al. Carcinoma of the oesophagus: Pre-treatment assessment, correlation of radiation treatment parameters with survival and identification and management of radiation treatment failure. Cancer 1979;43:2254-2267.
37. Sule-Suso J, Brunt AM, Lindup R, et al. Hyperfractionated accelerated radiotherapy for carcinoma of he oesophagus. Clin Oncol 1991;3:209-213.