Studies on genotoxic effects of iron overload and alcohol in an animal model of hepatocarcinogenesis

Journal of Hepatology

Volumn 27, Issue 3, 1997, Pages 562-571

  Stål, Per ^d   Olsson, Jerker ^a   Svoboda, Peter ^b   Hultcrantz, Rolf ^c   Harms Ringdahl, Mats ^b   Eriksson, Lennart C ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d NONE

Author keywords

Ethanol; Genotoxicity; Hemochromatosis; Hepatocarcinogenesis; Initiation; Iron; Li ver damage

Indexed keywords

ALANINE AMINOTRANSFERASE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; GENOTOXICITY; IRON METABOLISM; IRON OVERLOAD; LIVER CARCINOGENESIS; LIVER INJURY; LIVER PARENCHYMA; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT;

EID: 0038066066     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(97)80362-5     Document Type: Article

References (51)

1. Niederau C, Fischer R, Sonnenberg A, Stremmel W, Trampisch HJ, Strohmeyer G. Survival and causes of death in cirrhotic and noncirrhotic patients with primary hemochromatosis. N Engl J Med. 313:1985;1256-1262.
2. Adami HO, Hsing AW, McLaughlin JK, Trichopoulos D, Hacker D, Ekbom A, et al. Alcoholism and liver cirrhosis in the etiology of primary liver cancer. Int J Cancer. 51:1992;898-902.
3. LeSage GD, Baldus WP, Fairbanks VF, Baggenstoss AH, McCall JT, Moore SB, et al. Hemochromatosis: genetic or alcohol-induced? Gastroenterology. 84:1983;1471-1477.
4. Irving MG, Halliday JW, Powell LW. Association between alcoholism and increased hepatic iron stores. Alcohol Clin Exp Res. 12:1988;7-13.
5. Fargion S, Mandelli C, Piperno A, Cesana B, Fracanzani AL, Fraquelli M, et al. Survival and prognostic factors in 212 Italian patients with genetic hemochromatosis. Hepatology. 15:1992;655-659.
6. Deugnier YM, Guyader G, Crantock L, Lopez JM, Yaouana J, Jouanolle H, et al. Primary liver cancer in genetic hemochromatosis: a clinical, pathological and pathogenic study of 54 cases. Gastroenterology. 104:1993;228-234.
7. Stål P, Hultcrantz R. Iron increases ethanol toxicity in rat liver. J Hepatol. 17:1993;108-115.
8. Olynyk J, Hall P, Reed W, Williams P, Kerr R, Mackinnon M. A long-term study of the interaction between iron and alcohol in an animal model of iron overload. J Hepatol. 22:1995;671-676.
9. Stål P, Johansson I, Ingelman-Sundberg M, Hagen K, Hultcrantz R. Hepatotoxicity induced by iron overload and alcohol. Studies on the role of chelatable iron, cytochrome P450 2E1 and lipid peroxidation. J Hepatol. 25:1996;538-546.
10. Tsukamoto H, Horne W, Kamimura S, Niemelä O, Parkkila S, Ylä-Herttuala S, et al. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest. 96:1995;620-630.
11. Nordmann R, Ribière C, Rouach H. Involvement of iron and iron-catalysed free radical production in ethanol metabolism and toxicity. Enzyme. 37:1987;57-69.
12. Shaw S, Jayatilleke E, Lieber CS. Lipid peroxidation as a mechanism of alcoholic liver injury: role of iron mobilization and microsomal induction. Alcohol. 5:1988;135-140.
13. Fletcher LM, Roberts FD, Irving MG, Powell LW, Halliday JW. Effects of iron loading on free radical scavenging enzymes and lipid peroxidation in rat liver. Gastroenterology. 97:1989;1011-1118.
14. Ingelman-Sundberg M, Johansson I. Mechanism of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450. J Biol Chem. 259:1984;6447-6458.
15. Dresow B, Albert C, Zimmerman I, Nielsen P. Ethane exhalation and vitamin E/ubiquinol status as markers of lipid peroxidation in ferrocene iron-loaded rats. Hepatology. 21:1995;1099-1105.
16. Loeb LA, James EA, Waltersdorph AM, Klebanoff SJ. Mutagenesis by the autoxidation of iron with isolated DNA. Proc Natl Acad Sci USA. 85:1988;3918-3922.
17. Imlay JA, Chin SM, Linn S. Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Science. 240:1988;640-642.
18. Vaca CE, Harms-Ringdahl M. Interaction of lipid peroxidation products with nuclear macromolecules. Biochim Biophys Acta. 1001:1989;35-43.
19. Kasai H, Crain PF, Kuchino Y, Nishimura S, Ootsuyama A, Tanooka H. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis. 7:1986;1849-1851.
20. Farber E, Sarma DSR. Hepatocarcinogenesis: a dynamic cellular perspective. Lab Invest. 56:1987;4-22.
21. Ito N, Tsuda H, Tatematsu M, Inoue T, Tagawa Y, Aoki T, et al. Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats - an approach for a new medium-term bioassay system. Carcinogenesis. 9:1988;387-394.
22. Rotstein J, Sarma DSR, Farber E. Sequential alterations in growth control and cell dynamics of rat hepatocytes in early precancerous steps in hepatocarcinogenesis. Cancer Res. 46:1986;2377-2385.
23. Solt DB, Farber E. New principle for the analysis of chemical carcinogenesis. Nature. 263:1976;702-703.
24. Stål P, Hultcrantz R, Möller L, Eriksson LC. The effects of dietary iron on initiation and promotion in chemical hepatocarcinogenesis. Hepatology. 21:1995;521-528.
25. Park CH, Bacon BR, Brittenham GM, Tavill AS. Pathology of dietary carbonyl iron overload in rats. Lab Invest. 57:1987;555-563.
26. Lieber CS, DeCarli LM. The feeding of ethanol in liquid diets. Alcohol Clin Exp Res. 10:1986;550-553.
27. Weibel ER, Kistler GS, Scherle WF. Practical stereological methods for morphometric cytology. J Cell Biol. 30:1966;23-38.
28. Hultcrantz R, Glaumann H. Studies on the rat liver following iron overload. Biochemical studies after iron removal. Lab Invest. 46:1982;383-393.
29. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 193:1951;265-275.
30. Beland FA, Dooley KL, Casciano DA. Rapid isolation of carcinogen-bound DNA and RNA by hydroxyapatite chromatography. J Chromatogr. 174:1979;177-186.
31. Park JW, Cundy KC, Ames BN. Detection of DNA adducts by high-performance liquid chromatography with electrochemical detection. Carcinogenesis. 10:1989;827-832.
32. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:1979;351-358.
33. Åberg F, Appelkvist E-L, Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. Arch Biochem Biophys. 295:1992;230-234.
34. Bacon BR, Britton RS. The pathology of hepatic iron overload: a free radical mediated process? Hepatology. 11:1990;127-137.
35. Britton RS, Ferrali M, Magiera CJ, Recknagel RO, Bacon BR. Increased prooxidant action of hepatic cytosolic low-molecular-weight iron in experimental iron overload. Hepatology. 11:1990;1038-1043.
36. Kawase T, Kato S, Lieber CS. Lipid peroxidation and anti-oxidant defense systems in rat liver after chronic ethanol feeding. Hepatology. 10:1989;815-821.
37. Kamimura S, Gaal K, Britton RS, Bacon BR, Triadafilopoulos G, Tsukamoto H. Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis. Hepatology. 16:1992;448-453.
38. Teare JP, Greenfield SM, Watson D, Punchard NA, Miller N, Rice-Evans CA, et al. Lipid peroxidation in rats chronically fed ethanol. Gut. 35:1994;1644-1647.
39. Topham R, Goger M, Pearce K, Schultz P. The mobilization of ferritin iron by liver cytosol. A comparison of xanthine and NADH as reducing substances. Biochem J. 261:1989;137-143.
40. Sergent O, Morel I, Cogrel P, Chevanne M, Pasdeloup N, Brissot P, et al. Increase in cellular pool of low-molecular weight iron during ethanol metabolism in rat hepatocyte cultures. Relationship with lipid peroxidation. Biol Trace Elem Res. 47:1995;185-192.
41. Bacon BR, Britton RS, O'Neill R. Effects of vitamin E deficiency on hepatic mitochondrial lipid peroxidation and oxidative metabolism in rats with chronic dietary iron overload. Hepatology. 9:1989;398-404.
42. Sadrzadeh SM, Nanji AA, Meydani M. Effect of chronic ethanol feeding on plasma and liver alpha- and gamma-tocopherol levels in normal and vitamin E-deficient rats. Relationship to lipid peroxidation. Biochem Pharmacol. 47:1994;2005-2010.
43. Faux SP, Francis JE, Smith AG, Chipman JK. Induction of 8-hydroxydeoxyguanosine in Ah-responsive mouse liver by iron and Aroclor 1254. Carcinogenesis. 13:1992;247-250.
44. Lieber CS, Garro A, Leo MA, Mak KM, Worner T. Alcohol and cancer. Hepatology. 6:1986;1005-1019.
45. Tsutsumi M, Matsuda Y, Takada A. Role of ethanol-inducible cytochrome P-450 2E1 in the development of hepatocellular carcinoma by the chemical carcinogen, N-nitrosodimethylamine. Hepatology. 18:1993;1483-1489.
46. Diehl AM, Bisgaard HC, Kren BT, Steer CJ. Ethanol interferes with regeneration-associated changes in biotransformating enzymes: a potential mechanism underlying ethanol's carcinogenicity? Hepatology. 13:1991;722-727.
47. Baroni GS, Marucci L, Benedetti A, Mancici R, Jezequel AM, Orlandi F. Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver. J Hepatol. 20:1994;508-513.
48. 1-induced hepatocarcinogenesis in male ACI/N rats. Jpn J Cancer Res. 80:1989;526-530.
49. Yamauchi M, Nakahara M, Maezawa Y, Satoh S, Nishikawa F, Ohata M, et al. Prevalence of hepatocellular carcinoma in patients with alcoholic cirrhosis and prior exposure to hepatitis C. Am J Gastroenterol. 88:1993;39-43.
50. Takada A, Nei J, Takase S, Matsuda Y. Effects of ethanol on experimental hepatocarcinogenesis. Hepatology. 6:1986;65-72.
51. Ballardini G, Groff P, Zoli M, Bianchi GP, Giostra F, Francesconi R, et al. Increased risk of hepatocellular carcinoma development in patients with cirrhosis and with high hepatocellular proliferation. J Hepatol. 20:1994;218-222.