RHCE-D-CE hybrid genes can cause false-negative DNA typing of the Rh e antigen

Vox Sanguinis

Volumn 83, Issue 3, 2002, Pages 268-272

  Hundhausen, Thomas ^a,c   Petershofen, E K ^a   Doescher, A ^a   Bauerfeind, U ^b   Muller T H ^b   Schunter, F ^a  

^a Molecular Diagnostics   (Germany)

^b Institute Springe   (Germany)

^c KLINIKUM OLDENBURG   (Germany)

Author keywords

False negative; Genotype and phenotype; Human blood groups; Rh e; Rhesus (RH) DNA typing

Indexed keywords

BLOOD GROUP E ANTIGEN; RHESUS ANTIGEN;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA FINGERPRINTING; DNA POLYMORPHISM; EXON; GENE; GENOTYPE; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; RHCE D CE HYBRID GENE; SEROTYPING;

BLOOD GROUPING AND CROSSMATCHING; EPITOPES; FALSE NEGATIVE REACTIONS; GENE REARRANGEMENT; GENOTYPE; GLYCOPROTEINS; HUMANS; PEDIGREE; RH-HR BLOOD-GROUP SYSTEM;

EID: 0038052865     PISSN: 00429007     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1423-0410.2002.00220.x     Document Type: Article

References (25)

1. Flegel W, Wagner F: Molecular genetics of RH. Vox Sang 2000; 78:109-115
2. Mouro I, Colin Y, Cherif-Zahar B, Cartron J, Le van Kim C: Molecular genetic basis of the human Rhesus blood group system. Nat Genet 1993; 5:62-65
3. Iwamoto S, Yamasaki M, Kawano M, Okuda H, Omi T, Takahashi J, Tani Y, Omine M, Kajii E: Expression analysis of human Rhesus blood group antigens by gene transduction into erythroid and non-erythroid cells. Int J Hematol 1998; 68:257-268
4. Faas B, Simsek S, Bleeker P, Overbeeke M, von Cuijpers H, dem Borne AE, van der Schoot CE: Rh E/e genotyping by allele-specific primer amplification. Blood 1995; 85:829-832
5. Geifman-Holtzman O, Bernstein I, Berry S, Bianchi D, Holtzman E: Rapid molecular determination of fetal rhesus E type. Prenat Diagn 1996; 16:489-493
6. Rose N, Hurwitz C, Silberstein L, Andovalu R, Stoerker J: Prenatal analysis of rhesus CcDEe blood groups by heteroduplex generator. Am J Obstet Gynecol 1997; 176:1084-1089
7. Beckers EA, von Faas BH, dem Borne AE, Overbeeke MA, van Rhenen DJ, van der Schoot CE: The RoHar RH:33 phenotype results from substitution of exon 5 of the RHCE gene by the corresponding exon of the RHD gene. Br J Haematol 1996; 92:751-757
8. Nance S, Garratty G: A new potentiator of red blood cell antigen-antibody reactions. Am J Clin Pathol 1987; 87:633-635
9. Muller TH, Gassner C, Gran S, Wagner FF, Flegel WA, Schunter F: Semiautomated rhesus DNA-typing by multiplex PCR: 4 reactions with 15 sequence-specific primer pairs. Transfusion 1997; 37:19
10. Poulter M, Kemp T, Carritt B: DNA-based rhesus typing: simultaneous determination of RHC and RHD status using the polymerase chain reaction. Vox Sang 1996; 70:164-168
11. Flegel WA, Wagner FF, Muller TH, Gassner C: Rh phenotype prediction by DNA typing and its application to practice. Transfus Med 1998; 8:281-302
12. Tanaka M, Seno T, Shibata H, Okubo Y, Okuda H, Kajii E, Utsumi R: Genotyping for RhC/c and RhE/e by PCR using allele-specific oligonucleotide primers. Nippon Hoigaku Zasshi 1997; 51:32-38
13. Shields J: Prenatal typing of fetal DNA in cases of potential alloimmune haemolytic disease of the newborn: clinical benefit outweighs disadvantage. Br J Biomed Sci 1999; 56:49-55
14. Doscher A, Petershofen EK, Schunter F, Muller TH: Rhesus-D zygosity assesed by quantitative fluorogenic PCR. Infus Ther Transfus Med 2001; 28:41
15. Huang C, Liu P, Cheng J: Molecular biology and genetics of the Rh blood group system. Semin Hematol 2000; 37:150-165
16. Noizat-Pirenne F, Mouro I, Gane P, Okubo Y, Hori Y, Rouger P, Le PP, Cartron J: Heterogeneity of blood group RhE variants revealed by serological analysis and molecular alteration of the RHCE gene and transcript. Br J Haematol 1998; 103:429-436
17. Cheng GJ, Chen Y, Reid ME, Huang CH: Evans antigen: a new hybrid structure occurring on background of D. and D-Rh complexes. Vox Sang 2000; 78:44-51
18. Noizat-Pirenne F, Mouro I, Le Pennec PY, Ansart-Pirenne H, Juszczak G, Patereau C, Verdier M, Babinet J, Roussel M, Rouger P, Cartron JP: Two new alleles of the RHCE gene in Black individuals: the RHce allele ceMO and the RHCE allele cEMI. Br J Haematol 2001; 113:672-679
19. Hemker MB, Ligthart PC, Berger L, van Rhenen DJ, van der Schoot CE, Wijk PA: DAR, a new RhD variant involving exons 4, 5, and 7, often in linkage with ceAR, a new Rhce variant frequently found in African blacks. Blood; 94:4337-4342
20. Fisk N, Bennett P, Warwick R, Letsky E, Welch R, Vaughan J, Moore G: Clinical utility of fetal RhD typing in alloimmunized pregnancies by means of polymerase chain reaction on amniocytes or chorionic villi. Am J Obstet Gynecol 1994; 171:50-54
21. Chan F, Cowley N, Wolter L, Stone M, Carmody F, Saul A, Hyland C: Prenatal RHD gene determination and dosage analysis by PCR: clinical evaluation. Prenat Diagn 2001; 21:321-326
22. Okuda H, Kawano M, Iwamoto S, Tanaka M, Seno T, Okubo Y, Kajii E: The RHD gene is highly detectable in RhD-negative Japanese donors. J Clin Invest 1997; 100:373-379
23. Denomme GA, Akoury H, Sermer M, Kelton JG: RhD status of a fetus at risk for haemolytic disease with a discrepant maternal DNA-based RhD genotype. Prenat Diagn 1999; 19:424-427
24. Rouillac C, Puillandre P, Brossard Y: Comparison of 2 allele specific PCR methods for RHC fetal genotyping. Vox Sang 2000; 78:91
25. Noizet-Pirenne F, Le Pennec PY, Mouro I, Rouzaud AM, Juszczak G, Roussel M, Lauroua P, Krause C, Rouger P, Cartron JP, Ansart-Pirenne H: Molecular background of D(c)(e) haplotypes within the white population. Transfusion 2002; 42:627-633