P-locus is a target for the melanogenic effects of MC-1R signaling: A possible control point for facultative pigmentation

Annals of the New York Academy of Sciences

Volumn 994, Issue , 2003, Pages 373-377

  Ancans, Janis ^a   Flanagan, Niamh ^b   Hoogduijn, Martin J ^a   Thody, Anthony J ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Melanocortin peptides receptor; P locus; Pigmentation

Indexed keywords

ALPHA INTERMEDIN; BUCLADESINE; CYCLIC AMP DERIVATIVE; GLYCINE CLEAVAGE SYSTEM; MELANOCORTIN 1 RECEPTOR;

CONFERENCE PAPER; FAIR SKIN; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; MELANOCYTE; MELANOGENESIS; P LOCUS; PIGMENTATION; SIGNAL TRANSDUCTION; SKIN COLOR; SKIN PIGMENTATION; ULTRAVIOLET RADIATION;

EID: 0038050981     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb03202.x     Document Type: Conference Paper

References (23)

1. TSATMALI, M. et al. 2002. Melanocyte function and its control by melanocortin peptides. J. Histochem. Cytochem. 50: 125-133.
2. LERNER, A.B. & J.S. MCGUIRE. 1964. Melanocyte-stimulating hormone and adrenocorticotropic hormone. Their relation to pigmentation. N. Engl. J. Med. 270: 539-546.
3. LEVINE, N. et al. 1991. Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin. JAMA 266: 2730-2736.
4. KRUDE, H. et al. 1998. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. Genet. 19: 155-157.
5. TSATMALI, M. et al. 1999. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell. Mol. Biol. (Noisy-le-grand) 45: 1029-1034.
6. BUSCA, R. & R. BALLOTTI. 2000. Cyclic AMP a key messenger in the regulation of skin pigmentation. Pigm. Cell Res. 13: 60-69.
7. REES, J.L. 2000. The melanocortin 1 receptor (MC1R): more than just red hair. Pigm. Cell Res. 13: 135-140.
8. SCHIOTH, H.B. et al. 1999. Loss of function mutations of the human melanocortin 1 receptor are common and are associated with red hair. Biochem. Biophys. Res. Commun. 260: 488-491.
9. BOX, N.F. et al. 1997. Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. Hum. Mol. Genet. 6: 1891-1897.
10. SMITH, R. et al. 1998. Melanocortin 1 receptor variants in an Irish population. J. Invest. Dermatol. 111: 119-122.
11. PALMER, J.S. et al. 2000. Melanocortin-1 receptor polymorphisms and risk of melanoma: is the association explained solely by pigmentation phenotype? Am. J. Hum. Genet. 66: 176-186.
12. BASTIAENS, M.T. et al. 2001. Melanocortin-1 receptor gene variants determine the risk of nonmelanoma skin cancer independently of fair skin and red hair. Am. J. Hum. Genet. 68: 884-894.
13. KENNEDY, C. et al. 2001. Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color. J. Invest. Dermatol. 117: 294-300.
14. HARDING, R.M. 2000. et al. Evidence for variable selective pressures at MC1R. Am. J. Hum. Genet. 66: 1351-1361.
15. STURM, R.A. et al. 2001. Human pigmentation genes: identification, structure and consequences of polymorphic variation. Gene 277: 49-62.
16. ANCANS, J. & A.J. THODY. 2000. Activation of melanogenesis by vacuolar type H(+)-ATPase inhibitors in amelanotic, tyrosinase positive human and mouse melanoma cells. FEBS Lett. 478: 57-60.
17. ANCANS, J. et al. 2001. Melanosomal pH controls rate of melanogenesis, eumelanin/ phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells. Exp. Cell Res. 268: 26-35.
18. FULLER, B.B. et al. 2001. Regulation of the catalytic activity of pre-existing tyrosinase in black and Caucasian human melanocyte cell cultures. Exp. Cell Res. 262: 197-208.
19. ANCANS, J. et al. 2001. Melanosomal pH, pink locus protein and their roles in melanogenesis. J. Invest. Dermatol. 117: 158-159.
20. MANGA, P. & S.J. ORLOW. 2001. Inverse correlation between pink-eyed dilution protein expression and induction of melanogenesis by bafilomycin A1. Pigm. Cell Res. 14: 362-367.
21. BRILLIANT, M.H. 2001. The mouse p (pink-eyed dilution) and human P genes, oculocutaneous albinism type 2 (OCA2), and melanosomal pH. Pigm. Cell Res. 14: 86-93.
22. SUZUKI, I. et al. 2002. Increase of pro-opiomelanocortin mRNA prior to tyrosinase, tyrosinase-related protein 1, dopachrome tautomerase, Pmel-17/gp100, and P-protein mRNA in human skin after ultraviolet B irradiation. J. Invest. Dermatol. 118: 73-78.
23. LEE, S.T. et al. 1995. Organization and sequence of the human P gene and identification of a new family of transport proteins. Genomics 26: 354-363.