Omeprazole reduces clozapine plasma concentrations: A case report

Pharmacopsychiatry

Volumn 36, Issue 3, 2003, Pages 121-123

  Frick, A ^a   Kopitz, J ^a   Bergemann, Niels ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; CLOZAPINE; CYTOCHROME P450 1A2; OMEPRAZOLE; PROTON PUMP INHIBITOR;

ADULT; ARTICLE; CASE REPORT; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG MONITORING; ENZYME INDUCTION; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; MALE; PLASMA CLEARANCE; PRIORITY JOURNAL; SCHIZOAFFECTIVE PSYCHOSIS;

ADULT; ANTIPSYCHOTIC AGENTS; CLOZAPINE; CYTOCHROME P-450 CYP1A2; DRUG ANTAGONISM; ESOPHAGITIS; FEMALE; GASTRITIS; HUMANS; MALE; OMEPRAZOLE; PROTON PUMPS; PSYCHOTIC DISORDERS;

EID: 0038049599     PISSN: 01763679     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-39980     Document Type: Article

References (17)

1. Andersson T. Pharmacokinetics, metabolism and interactions of acid pump inhibitors. Clin Pharmacokinet 1996; 31: 9 - 28
2. Ayrton A, Morgan P. Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica 2001; 31: 469 - 497
3. Edge SC, Markowitz JS, Devane CL. Clozapine drug interactions: a review of the literature. Human Psychopharmacol 1997; 12: 5 - 20
4. Eiermann B, Engel G, Johansson I, Zanger UM, Bertilsson L. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. Br J Clin Pharmacol 1997; 44: 439 - 446
5. Fischer V, Vogels B, Maurer G, Tynes R. The antipsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cyochrome P450 2D6. J Pharmacol Exp Ther 1992; 260: 1355 - 1366
6. Flockhard DA. Drug interactions and the cytochrome P450 system. The role of P450 2C19. Clin Pharmacokinet 1995; 29: 45 - 52
7. Gaertner I, Gaertner HJ, Vonthein R, Dietz K. Therapeutic drug monitoring of clozapine in relapse prevention: a five-year prospective study. J Clin Psychopharmacol 2001; 21: 305 - 310
8. Lane HY, Jann MW, Chang YC, Chiu CC, Huang MC, Lee SH, Chang WH. Repeated ingestion of grapefruit juice does not alter clozapine's steady state plasma levels. J Clin Psychiatry 2001; 62: 812 - 817
9. Linnet K, Olesen OV. Metabolism of clozapine by cDNA-expressed human cytochrome P450 enzymes. Drug Metab Dispos 1997; 25: 1379 - 1382
10. Masubuchi N, Li AP, Okazaki O. An evaluation of cytochrome P450 induction potential of pantoprazole in primary human hepatocytes. Chem Biol Interact 1998; 114: 1 - 13
11. Neuhoff S, Langguth P, Dressler C, Andersson TB, Regardh CG, Spahn-Langguth H. Affinities at the verapamil binding site of MDR1-encoded P-glycoprotein: drugs and analogs, stereoisomers and metabolites. Int J Clin Pharmacol Ther 2000; 38: 168 - 179
12. Olesen OV, Linnet K. Contributions of five human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations. J Clin Pharmacol 2001; 41: 823 - 832
13. Robinson M. New generation proton pump inhibitors: overcoming the limitations of early-generation agents. Eur J Gastroenterol Hepatol 2001; 13: 43 - 47
14. 13C-(N-3-methyl)-caffeine breath test in poor and extensive metabolizers of S-mephenytoin. Clin Pharmacol Ther 1992; 52: 170 - 180
15. Rost KL, Fuhr U, Thomsen T, Zaigler M, Brockmöller J, Bohnemeier H, Roots I. Omeprazole weakly inhibits CYP1A2 activity in man. Int J Clin Pharmacol Ther 1999; 37: 567 - 557
16. Stevens I, Glaenz D, Krauss F, Walz G, Gaertner HJ. Bedeutung des therapeutischen Drug-Monitoring im Rahmen der Rezidivprophylaxe mit Clozapin. In: Naber D, Müller-Spahn F (eds.). Leponex. Pharmakologie und Klinik eines atypischen Neuroleptikums. Berlin, Heidelberg: Springer, 1999: 79 - 89
17. Weigmann H, Hiemke C. Determination of clozapine and its major metabolites in human serum using automated solid-phase extraction and subsequent isocratic high-performance liquid chromatography with ultraviolet detection. J Chromatogr 1992; 583: 209 - 216