Preliminary efficacy of levetiracetam in children

Epileptic Disorders

Volumn 5, Issue SUPPL. 1, 2003, Pages

  Glauser, Tracy A ^a   Dulac, Olivier ^b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b HÔPITAL SAINT VINCENT DE PAUL   (France)

Author keywords

Efficacy; Levetiracetam; Pediatric; Pharmacokinetics; Safety; Seizure

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETIRACETAM; FELBAMATE; GABAPENTIN; LAMOTRIGINE; PRIMIDONE; TOPIRAMATE; VALPROIC ACID;

AGE DISTRIBUTION; ANOREXIA; BEHAVIOR DISORDER; CHILD; CLINICAL TRIAL; DATA ANALYSIS; DOSE CALCULATION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG INFORMATION; DRUG SAFETY; DRUG TOLERABILITY; EPILEPSY; EXPERIENCE; FOCAL EPILEPSY; FOLLOW UP; GRAND MAL SEIZURE; HEADACHE; HUMAN; INFECTION; IRRITABILITY; LENNOX GASTAUT SYNDROME; LETHARGY; MEDICAL RECORD; MYOCLONIC ASTATIC EPILEPSY; PEDIATRICS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSYCHOSIS; RETROSPECTIVE STUDY; REVIEW; SEIZURE; SIDE EFFECT; SOMNOLENCE; WEIGHT GAIN; WEIGHT REDUCTION;

ANTICONVULSANTS; CHILD; DRUG ADMINISTRATION SCHEDULE; EPILEPSY; HUMANS; PIRACETAM; PROSPECTIVE STUDIES; SEIZURES;

EID: 0038045659     PISSN: 12949361     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Pellock JM, Appleton R. Use of new antiepileptic drugs in the treatment of childhood epilepsy. Epilepsia 1999; 40(Suppl 6): S29-38.
2. Shields WD. Catastrophic epilepsy in childhood. Epilepsia 2000; 41 (Suppl 2): S2-6.
3. Amann JP, Dulac O. Trials in children. Epilepsy Res 2001; 45: 133-6.
4. Dulac O, Guerrini R. Seizure types and syndromes: lumping or splitting. Epilepsy Res 2001; 45: 37-40.
5. Pellock JM. Treatment of seizures and epilepsy in children and adolescents. Neurology 1998; 51 (Suppl 4): S8-14.
6. Pellock JM. Managing pediatric epilepsy syndromes with new antiepileptic drugs. Pediatrics 1999; 104: 1106-16.
7. Pellock JM. Drug treatment in children. In: Engel J Jr, Pedley TA. Epilepsy: A Comprehensive Textbook. Philadelphia: Lippincott-Raven Publishers, 1997: 1205-10.
8. Hovinga CA. Levetiracetam: a novel antiepileptic drug. Pharmacotherapy 2001; 21: 1375-88.
9. Glauser TA, Pellock JM, Bebin EM. Efficacy and safety of levetiracetam in children with partial seizures: an open-label trial. Epilepsia 2002; 43: 518-24.
10. Harden C. Safety profile of levetiracetam. Epilepsia 2001; 42(Suppl 4): 36-9.
11. Crumrine PK. Lennox-Gastaut syndrome. J Child Neurol 2002; 17(Suppl 1): S70-5.
12. Kaminska A, Ickowicz A, Plouin P, et al. Delineation of cryptogenic Lennox-Gastaut syndrome and myoclonic astatic epilepsy using multiple correspondence analysis. Epilepsy Res 1999; 36: 15-29.
13. Doose H. Myoclonic-astatic epilepsy. Epilepsy Res 1992; 6(Suppl): 163-8.
14. de los Reyes EC, Sharp GB, Hale SE. Levetiracetam in the treatment of Lennox-Gastaut syndrome. Ann Neurol 2001; 50(Suppl 1): S108.
15. Berg AT, Shinnar S, Levy SR, et al. Newly diagnosed epilepsy in children: presentation at diagnosis. Epilepsia 1999; 40: 445-52.
16. Bebin M. Pediatric partial and generalized seizures. J Child Neurol 2002; 17(Suppl 1): S65-9.
17. Barron TF, Faircloth VC, Yuncker LA, et al. Levetiracetam adjunct therapy for refractory pediatric generalized epilepsies. Epilepsia 2001; 42(Suppl 7): 53.
18. Bourgeois BFD, Holder DL, Valencia I, et al. Open-label assessment of levetiracetam efficacy and adverse effects in a pediatric population. Epilepsia 2001; 42(Suppl 7): 53-4.
19. Mandelbaum DE, Kugler SL, Wenger EC, etal. Clinical experience with levetiracetam and zonisamide in children with uncontrolled epilepsy. Epilepsia 2001; 42(Suppl 7): 182.
20. Ng Y, Wheless JW. Levetiracetam: pediatric experience. Epilepsia 2001; 42(Suppl 7): 55-6.
21. Gustafson MC, Ritter FJ, Frost MD, etal. Clinical experience with levetiracetam treating refractory, symptomatic seizures in children. Epilepsia 2001; 42(Suppl 7): 55.
22. Hovinga C, Morris H, Holland K, etal. Levetiracetam efficacy in adults and children. Epilepsia 2001; 42(Suppl 7): 213.
23. Strunc MJ, Levisohm PM. Tolerability and efficacy of levetiracetam in children. Epilepsia 2001; 42(Suppl 7): 92.
24. Faircloth VC, Hunt SL, Yuncker LA, et al. Levetiracetam adjunctive therapy for refractory pediatric focal-onset epilepsy. Epilepsia 2001; 42(Suppl 7): 54.
25. Wannag E, Eriksson A-S, Brockmeier K. Tolerability of levetiracetam in children with refractory epilepsy. Epilepsia 2001; 42(Suppl 7): 57.
26. Kossoff EH, Bergey GK, Freeman JM, et al. Levetiracetam psychosis in children with epilepsy. Epilepsia 2001; 42: 1611-13.
27. Pellock JM, Glauser TA, Bebin EM, et al. Pharmacokinetic study of levetiracetam in children. Epilepsia 2001; 42: 1574-79.
28. Patsalos PN. Pharmacokinetic profile of levetiracetam: toward ideal characteristics. Pharmacol Ther 2000; 85: 77-85.
29. Wallace SJ. A comparative review of the adverse effects of anticonvulsants in children with epilepsy. Drug Saf 1996; 15: 378-93.
30. Glauser TA. Expending first-line therapy options for children with partial seizures. Neurology 2000; 55(Suppl 3): S30-7.