Dietary low-dose sucrose modulation of IQ-induced genotoxicity in the colon and liver of Big Blue™ rats

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 527, Issue 1-2, 2003, Pages 91-97

  Møller, Peter ^a   Hansen, Max ^b   Autrup, Herman ^c   Bornholt, Jette ^d   Vogel, Ulla ^d   Mølck, Anne Marie ^b,e   Wallin, Håkan ^d   Dragsted, Lars O ^b   Risom, Lotte ^a   Poulsen, Henrik E ^a   Loft, Steffen ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b DANISH VETERINARY AND FOOD ADMINISTRATION   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^e NOVO NORDISK A S   (Denmark)

Author keywords

Apoptosis; BigBlue rat; DNA adducts; DNA repair; Mutations; Strand breaks

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 2 AMINOADIPIC SEMIALDEHYDE; 7 HYDRO 8 OXO 2' DEOXYGUANOSINE; ALDEHYDE DERIVATIVE; ASCORBIC ACID; BIOLOGICAL MARKER; DEOXYGUANOSINE DERIVATIVE; DNA GLYCOSYLTRANSFERASE; ENDONUCLEASE; GAMMA GLUTAMYLSEMIALDEHYDE; MALONALDEHYDE; SUCROSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON; COLON MUCOSA; CONTROLLED STUDY; DIETARY INTAKE; DNA ADDUCT; DNA DAMAGE; DNA STRAND BREAKAGE; GENE EXPRESSION; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; LIVER TOXICITY; MALE; MUTATION RATE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PLASMA; PRIORITY JOURNAL; RAT; SUGAR INTAKE;

EID: 0038022956     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(03)00058-7     Document Type: Article

References (13)

1. Doll R., Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst. 66:1981;1191-1308.
2. Skog K.I., Johansson M.A.E., Jägerstad M.I. Carcinogenic heterocyclic amines in model systems and cooked foods: a review on formation, occurrence and intake. Fed. Chem. Toxicol. 36:1998;879-896.
3. IARC, IQ (2-amino-3-methylimidazo[4,5-f]quinoline), in: IARC (Ed.), IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins, IARC, Lyon, 1993, pp. 165-195.
4. J. Alexander, H. Wallin, Metabolic fate of heterocyclic amines from cooked food, in: H. Hayatsu (Ed.), Mutagens in Food: Detection and Prevention, CRC Press, Boca Raton, FL, 1991, pp. 143-152.
5. Slattery M.L., Benson J., Berry T.D., Duncan D., Edwards S.L., Caan B.J., Potter J.D. Dietary sugar and colon cancer. Cancer Epidemiol. Biomarkers Prev. 6:1997;677-685.
6. Stamp D., Zhang X.-M., Medline A., Bruce W.R., Archer M.C. Sucrose enhancement of the early steps of colon carcinogenesis in mice. Carcinogenesis. 14:1993;777-779.
7. Kristiansen E., Meyer O., Thorup I. Refined carbohydrate enhancement of aberrant crypt foci (ACF) in rat colon induced by the food-borne carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Cancer Lett. 105:2001;147-151.
8. Poulsen M., Mølck A.-M., Thorup I., Breinholt V., Meyer O. The influence of simple sugars and starch given during pre- or post-initiation on aberrant crypt foci in rat colon. Cancer Lett. 167:2001;135-143.
9. Dragsted L.O., Daneshvar B., Vogel U., Autrup H., Wallin H., Risom L., Møller P., Mølck A.-M., Hansen M., Poulsen H.E., Loft S. A sucrose-rich diet-induced mutations in the rat colon. Cancer Res. 62:2002;4339-4345.
10. Møller P., Wallin H., Vogel U., Autrup H., Risom L., Hald M.T., Daneshvar B., Dragsted L.O., Poulsen H.E., Loft S. Mutagenecity of 2-amino-3-methylimidazo[4,5-f]quinoline in colon and liver of Big Blue™ rats: role of DNA adducts, strand breaks and oxidative stress. Carcinogenesis. 23:2002;1379-1385.
11. Turesky R.J., Markovic J. DNA adduct formation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline at the C-8 and N-2 atoms of guanine. Chem. Res. Toxicol. 7:1994;752-761.
12. Turesky R.J., Markovic J. DNA adduct formation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in liver, kidney and colo-rectum of rats. Carcinogenesis. 16:1995;2275-2279.
13. Bruce W.R., Giaccia A., Medline A. Possible mechanisms relating diet and risk of colon cancer. Cancer Epidemiol. Biomarkers Prev. 9:2000;1271-1279.