Topical vanadate optimizes collagen organization within granulation tissue

Wound Repair and Regeneration

Volumn 11, Issue 3, 2003, Pages 204-212

  Mackay, Duncan J D ^b   Moyer, Kurtis E ^b   Saggers, Gregory C ^b   Myers, Roland L ^b   Mackay, Donald R ^b   Ehrlich, H Paul ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; COLLAGEN FIBER; PHALLOIDIN; POLYVINYL ALCOHOL SPONGE; PROTEIN TYROSINE PHOSPHATASE; SODIUM CHLORIDE; VANADIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIREFRINGENCE; CONNECTIVE TISSUE; CONTROLLED STUDY; ELECTRON MICROSCOPY; GRANULATION TISSUE; IMMUNOHISTOLOGY; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; RAT; SCAR FORMATION; VASCULAR SMOOTH MUSCLE;

ADMINISTRATION, TOPICAL; ANIMALS; COLLAGEN; DRUG IMPLANTS; GRANULATION TISSUE; MICROSCOPY, ELECTRON; RATS; VANADATES; WOUND HEALING;

EID: 0038021302     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.2003.11309.x     Document Type: Article

References (19)

1. Darby I, Gabbiani G. α smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest 1990;65:21-9.
2. Van Zuijlen PPM, Angelse AP, Krebs RW, Bos KE, Middelkoop E. Scar assessment tools: implications for current research. Plast Reconstr Surg 2002;109:1108-22.
3. Cohen IK, Keiser HR. Disruption of healed scars in scurvy the result of disequilibrium in collagen metabolism. Plast Reconst Surg 1976;57:213-5.
4. DeClue JE, Martin GS. Phosphorylations of talin at tyrosine in rous sarcoma virus transformed cells. Mol Cell Biol 1987;7:371-8
5. Yang C, Chang J, Gorospe M, Passaniti A. Protein tyrosine phosphatase regulation of endothelial cell apoptosis and differentiation. Cell Grow Differ 1996;7:161-71.
6. Ehrlich HP, Keefer KA, Myers RI, Passaniti A. Wound contraction, vanadate and myofibroblasts. Arch Surg 1999;134:494-501.
7. Ehrlich HP, Keefer KA, Maish GO III, Myers RL, Mackay DR. The increased gain in wound breaking strength associated with more uniform deposited collagen fiber bundles in vanadate treated rats. Plast Reconst Surg 2001;107:471-7.
8. Kornberg L, Earp HS, Parsons JT, Schaller M, Juliano RL. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J Biol Chem 1992;267:23439-42.
9. Retta SF, Barry ST, Critchley DR, Defilippi P, Silengo L, Tarone G. Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity. Exp Cell Res 1996;229:307-17.
10. Sandberg N. Time relationship between administration of cortisone and wound healing in rats. Acta Chir Scand 1964;127:446-55.
11. Mustoe TA, Pierce GF, Thomasen A, Gramates P, Sporn MB, Deuel TF. Accelerated healing of incisional wounds in rats induced by transforming growth factor-β. Science 1997;237:1333-6.
12. Ehrlich HP, Desmouliere A, Diegelmann RF, Cohen IK, Compton CC, Garner WL, Kapanci Y, Gabbiani G. Morphological and immunochemical differences between keloids and hypertrophic scar. Am J Pathol 1994;145:105-13.
13. Dugina V, Jontao L Chaponnier C, Vasiliev J, Gabbiani G. Focal adhesion features during myofibroblastic differentiation are controlled by intracellular and extracellular factors. J Cell Sci 2001;114:3285-96.
14. Tomasek JT, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechanco-regulation of connective tissue remodeling. Nat Rev Mol Cell Biol 2002;3:349-63.
15. Maher PA, Pasquale EB, Wang JYJ, Singer SJ. Phospho-tyrosine containing proteins are concentrated in focal adhesions and intercellular junctions. Proc Nat Acad Sci USA 1985;82:6576-80.
16. Daum G, Levkau B, Chamberlain NL, Wang Y, Clowes AW. The mitogen-activated protein kinase pathway contributes to vanadate toxicity in vascular smooth muscle cells. Mol Cell Biochem 1998;183:97-103.
17. Jin N, Siddiqui RA, English D, Rhoades RA. Communication between tyrosine kinase pathway and myosin light chain kinase pathway in smooth muscle. Am J Physiol 1996;271:H1348-55.
18. Ehrlich HP, Rajaratnam JB. Cell locomotion forces versus cell contraction forces for collagen lattice contraction: an in vitro model of wound contraction. Tiss Cell 1990;22:407-17.
19. McGee GS, Broadley KN, Buckley A, Aquino A, Woodward SC, Demetriou AA, Davidson JM. Recombinant transforming growth factor beta accelerates incisional wound healing. Curr Surg 1989;46:103-6.