Synthesis of new 14-membered macrolide antibiotics via a novel ring contraction metathesis

Organic Letters

Volumn 5, Issue 4, 2003, Pages 443-445

  Lazarova, Tsvetelina I ^a   Binet, Sophie M ^a   Vo, Nha H ^a   Chen, Jason S ^a   Phan, Ly T ^a   Or, Yat Sun ^a  

^a Enanta Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE DERIVATIVE; ERYTHROMYCIN; JOSAMYCIN; MACROLIDE; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL INFECTION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; RING CLOSING METATHESIS; RING OPENING METATHESIS POLYMERIZATION; CHEMISTRY; DRUG EFFECT; DRUG RESISTANCE; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE; ERYTHROMYCIN; JOSAMYCIN; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038002450     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol027322n     Document Type: Article

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23. The MIC assays were performed in accordance with the National Committee of Clinical Laboratory Standards (NCCLS) guidelines: (a) NCCLS Document M7-A5 (Vol. 20: No. 2). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, 5th ed., Jan 2000. (b) NCCLS Document M100-S11 (Vol. 21: No. 1). Performance Standards for Antimicrobial Susceptibility Testing: Eleventh Informational Supplement, Jan. 2001. (c) Amsterdam, D. Susceptibility Testing of Antimicrobials in Liquid Media. In Lorain, V. Antibiotics in Laboratory Medicine, 4th ed.; Williams & Wilkins: Baltimore, MD, 1996; pp 52-111.
24. The MIC assays were performed in accordance with the National Committee of Clinical Laboratory Standards (NCCLS) guidelines: (a) NCCLS Document M7-A5 (Vol. 20: No. 2). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, 5th ed., Jan 2000. (b) NCCLS Document M100-S11 (Vol. 21: No. 1). Performance Standards for Antimicrobial Susceptibility Testing: Eleventh Informational Supplement, Jan. 2001. (c) Amsterdam, D. Susceptibility Testing of Antimicrobials in Liquid Media. In Lorain, V. Antibiotics in Laboratory Medicine, 4th ed.; Williams & Wilkins: Baltimore, MD, 1996; pp 52-111.
25. The MIC assays were performed in accordance with the National Committee of Clinical Laboratory Standards (NCCLS) guidelines: (a) NCCLS Document M7-A5 (Vol. 20: No. 2). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, 5th ed., Jan 2000. (b) NCCLS Document M100-S11 (Vol. 21: No. 1). Performance Standards for Antimicrobial Susceptibility Testing: Eleventh Informational Supplement, Jan. 2001. (c) Amsterdam, D. Susceptibility Testing of Antimicrobials in Liquid Media. In Lorain, V. Antibiotics in Laboratory Medicine, 4th ed.; Williams & Wilkins: Baltimore, MD, 1996; pp 52-111.