메뉴 건너뛰기




Volumn 3, Issue 2, 2003, Pages 101-112

The use of Roxifiban (DMP754), a novel oral platelet glycoprotein IIb/IIIa receptor inhibitor, in patients with stable coronary artery disease

Author keywords

[No Author keywords available]

Indexed keywords

3 [[[3 [4 (AMINOIMINOMETHYL)PHENYL] 4,5 DIHYDRO 5 ISOXAZOLYL]ACETYL]AMINO] N (BUTOXYCARBONYL)ALANINE; ADENOSINE DIPHOSPHATE; ANTIANGINA PECTORIS AGENT; ANTICOAGULANT AGENT; CYCLO(DEXTRO 2 AMINOBUTYRYL 2 N METHYLARGINYLGLYCYLASPARTYL 3 AMINOMETHYLBENZOIC ACID) METHANESULFONATE; FIBRINOGEN RECEPTOR ANTAGONIST; PLACEBO; ROXIFIBAN;

EID: 0037981388     PISSN: 11753277     EISSN: None     Source Type: Journal    
DOI: 10.2165/00129784-200303020-00004     Document Type: Article
Times cited : (18)

References (37)
  • 1
    • 2242477091 scopus 로고
    • Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty
    • EPIC Investigators
    • EPIC Investigators. Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. N Engl J Med 1994; 330: 956-61
    • (1994) N. Engl. J. Med. , vol.330 , pp. 956-961
  • 2
    • 1842369101 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization
    • EPILOG Investigators
    • EPILOG Investigators. Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization. N Engl J Med 1997; 336: 1689-96
    • (1997) N. Engl. J. Med. , vol.336 , pp. 1689-1696
  • 3
    • 0028120906 scopus 로고
    • Collaborative overview of randomised trials of antiplatelet therapy: I. Antiplatelet Trialists' Collaborationprevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients
    • Collaborative overview of randomised trials of antiplatelet therapy: I. Antiplatelet Trialists' Collaborationprevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 1994; 308: 81-106
    • (1994) BMJ , vol.308 , pp. 81-106
  • 4
    • 0033609314 scopus 로고    scopus 로고
    • Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels
    • c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) Study Investigators
    • Hamm CW, Heeschen C, Goldmann B, et al. Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels. c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) Study Investigators. N Engl J Med 1999; 340: 1623-9
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1623-1629
    • Hamm, C.W.1    Heeschen, C.2    Goldmann, B.3
  • 5
    • 0034111390 scopus 로고    scopus 로고
    • Predictive value of C-reactive protein and troponin T in patients with unstable angina: A comparative analysis
    • CAPTURE Investigators. Chimeric c7E3 AntiPlatelet Therapy in Unstable angina Refractory to standard treatment trial
    • Heeschen C, Hamm CW, Bruemmer J, et al. Predictive value of C-reactive protein and troponin T in patients with unstable angina: a comparative analysis. CAPTURE Investigators. Chimeric c7E3 AntiPlatelet Therapy in Unstable angina Refractory to standard treatment trial. J Am Coll Cardiol 2000; 35: 1535-42
    • (2000) J. Am. Coll. Cardiol. , vol.35 , pp. 1535-1542
    • Heeschen, C.1    Hamm, C.W.2    Bruemmer, J.3
  • 6
    • 0032748152 scopus 로고    scopus 로고
    • Aspirin, ticlopidine, and clopidogrel in acute coronary syndromes: Underused treatments could save thousands of lives
    • 615-8, 621-4
    • Tan WA, Moliterno DJ. Aspirin, ticlopidine, and clopidogrel in acute coronary syndromes: underused treatments could save thousands of lives. Cleve Clin J Med 1999; 66: 615-8, 621-4, 627-8
    • (1999) Cleve. Clin. J. Med. , vol.66 , pp. 627-628
    • Tan, W.A.1    Moliterno, D.J.2
  • 7
    • 0031797743 scopus 로고    scopus 로고
    • Results of the CAPRIE trial: Efficacy and safety of clopidogrel. Clopidogrel versus aspirin in patients at risk of ischaemic events
    • Creager MA. Results of the CAPRIE trial: efficacy and safety of clopidogrel. Clopidogrel versus aspirin in patients at risk of ischaemic events. Vasc Med 1998; 3: 257-60
    • (1998) Vasc. Med. , vol.3 , pp. 257-260
    • Creager, M.A.1
  • 8
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee
    • CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996; 348: 1329-39
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 9
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment evaluation
    • Clopidogrel in Unstable Angina to Prevent Events (CURE) Investigators
    • Clopidogrel in Unstable Angina to Prevent Events (CURE) Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment evaluation. N Engl J Med 2001; 345 (7): 494-502
    • (2001) N. Engl. J. Med. , vol.345 , Issue.7 , pp. 494-502
  • 10
    • 0032578441 scopus 로고    scopus 로고
    • Pharmacodynamic efficacy,clinical safety, and outcomes after prolonged platelet glycoprotein iib/iiia receptor blockade with oral xemlofiban
    • Kereiakes D, Kleinman S, Ferguson J, et al. Pharmacodynamic efficacy,clinical safety, and outcomes after prolonged platelet glycoprotein iib/iiia receptor blockade with oral xemlofiban. Circulation 1998; 98: 1268-78
    • (1998) Circulation , vol.98 , pp. 1268-1278
    • Kereiakes, D.1    Kleinman, S.2    Ferguson, J.3
  • 11
    • 0034604123 scopus 로고    scopus 로고
    • Long-term treatment with a platelet glycoprotein-receptor antagonist after percutaneous coronary revascularization
    • for the EXCITE Trial Investigators
    • O'Neill WW, Serruys P, Knudtson M, et al. , for the EXCITE Trial Investigators. Long-term treatment with a platelet glycoprotein-receptor antagonist after percutaneous coronary revascularization. N Engl J Med 2000; 342: 1316-24
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1316-1324
    • O'Neill, W.W.1    Serruys, P.2    Knudtson, M.3
  • 12
    • 0033669932 scopus 로고    scopus 로고
    • Learning from the recently completed oral glycoprotein IIb/IIIa receptor antagonist trials
    • Cannon CP. Learning from the recently completed oral glycoprotein IIb/IIIa receptor antagonist trials. Clin Cardiol 2000; 23 Suppl VI: VI-14-7
    • (2000) Clin. Cardiol. , vol.23 , Issue.SUPPL. VI
    • Cannon, C.P.1
  • 13
    • 0032764887 scopus 로고    scopus 로고
    • Oral blockade of the platelet glycoprotein IIb/IIIa receptor: Fact or fancy?
    • Kereiakes DJ. Oral blockade of the platelet glycoprotein IIb/IIIa receptor: fact or fancy? Am Heart J 1999; 138 (1 Pt 2): S39-46
    • (1999) Am. Heart J. , vol.138 , Issue.1 PART 2
    • Kereiakes, D.J.1
  • 14
    • 0034127789 scopus 로고    scopus 로고
    • Comparative in vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet-mediated clot strength induced by tissue factor with use of thromboelastography: Differentiation among glycoprotein IIb/IIIa antagonists
    • Mousa SA, Bozarth JM, Forsythe MS. Comparative in vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet-mediated clot strength induced by tissue factor with use of thromboelastography: differentiation among glycoprotein IIb/IIIa antagonists. Arterioscler Thromb Vasc Biol 2000; 20: 1162-7
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 1162-1167
    • Mousa, S.A.1    Bozarth, J.M.2    Forsythe, M.S.3
  • 15
    • 0034756284 scopus 로고    scopus 로고
    • Platelet GPIIb/IIIa binding characteristics of small molecule RGD mimetic: Distinct binding profile for Roxifiban
    • Mousa SA, Bozarth JM, Naik UP, et al. Platelet GPIIb/IIIa binding characteristics of small molecule RGD mimetic: distinct binding profile for Roxifiban. Br J Pharmacol 2001; 133: 331-6
    • (2001) Br. J. Pharmacol. , vol.133 , pp. 331-336
    • Mousa, S.A.1    Bozarth, J.M.2    Naik, U.P.3
  • 16
    • 0035998752 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics, and time course of pharmacologic response of the active metabolite of roxifiban, XV459, a glycoprotein IIb/IIIa antagonist, following oral administration in healthy volunteers
    • Pieniaszek Jr HJ, Sy SK, Ebling W, et al. Safety, tolerability, pharmacokinetics, and time course of pharmacologic response of the active metabolite of roxifiban, XV459, a glycoprotein IIb/IIIa antagonist, following oral administration in healthy volunteers. J Clin Pharmacol 2002; 42: 738-53
    • (2002) J. Clin. Pharmacol. , vol.42 , pp. 738-753
    • Pieniaszek H.J., Jr.1    Sy, S.K.2    Ebling, W.3
  • 17
    • 0032886556 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of glycoprotein IIb-IIIa inhibitors
    • Kleiman NS. Pharmacokinetics and pharmacodynamics of glycoprotein IIb-IIIa inhibitors. Am Heart J 1999; 138: 263-75
    • (1999) Am. Heart J. , vol.138 , pp. 263-275
    • Kleiman, N.S.1
  • 18
    • 0030610564 scopus 로고    scopus 로고
    • Effect of Ca2+ on GP IIb-IIIa interactions with integrilin: Enhanced GP IIb-IIIa binding and inhibition of platelet aggregation by reductions in the concentration of ionized calcium in plasma anticoagulated with citrate
    • Phillips DR, Teng W, Arfsten A, et al. Effect of Ca2+ on GP IIb-IIIa interactions with integrilin: enhanced GP IIb-IIIa binding and inhibition of platelet aggregation by reductions in the concentration of ionized calcium in plasma anticoagulated with citrate. Circulation 1997; 96: 1488-94
    • (1997) Circulation , vol.96 , pp. 1488-1494
    • Phillips, D.R.1    Teng, W.2    Arfsten, A.3
  • 19
    • 0033847080 scopus 로고    scopus 로고
    • Differential antiplatelet efficacy for various GPIIb/IIIa antagonists: Role of plasma calcium levels
    • Mousa SA, Bozarth JM, Forsythe MS, et al. Differential antiplatelet efficacy for various GPIIb/IIIa antagonists: role of plasma calcium levels. Cardiovasc Res 2000; 47: 819-26
    • (2000) Cardiovasc. Res. , vol.47 , pp. 819-826
    • Mousa, S.A.1    Bozarth, J.M.2    Forsythe, M.S.3
  • 20
    • 0033566348 scopus 로고    scopus 로고
    • Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa
    • Bednar B, Cook JJ, Holahan MA, et al. Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa. Blood 1999; 94: 587-99
    • (1999) Blood , vol.94 , pp. 587-599
    • Bednar, B.1    Cook, J.J.2    Holahan, M.A.3
  • 21
    • 0037093079 scopus 로고    scopus 로고
    • Evidence that thrombocytopenia observed in humans treated with orally bioavialable glycoprotein IIb/IIIA antagonists is immune mediated
    • May 15
    • Billheimer JT, Dicker IB, Wynn R, et al. Evidence that thrombocytopenia observed in humans treated with orally bioavialable glycoprotein IIb/IIIA antagonists is immune mediated. Blood 2002 May 15; 99 (10): 3540-6
    • (2002) Blood , vol.99 , Issue.10 , pp. 3540-3546
    • Billheimer, J.T.1    Dicker, I.B.2    Wynn, R.3
  • 23
    • 0027320404 scopus 로고
    • Clinical trials of platelet receptor inhibitors
    • Topol EJ, Plow EF. Clinical trials of platelet receptor inhibitors. Thromb Haemost 1993; 70: 94-8
    • (1993) Thromb. Haemost. , vol.70 , pp. 94-98
    • Topol, E.J.1    Plow, E.F.2
  • 24
    • 8044235823 scopus 로고    scopus 로고
    • Novel nonpeptide antiplatelet glycoprotein IIb/IIIa receptor antagonist, DMP754: Receptor binding affinity and specificity
    • Mousa SA, Forsythe M, Lorelli W, et al. Novel nonpeptide antiplatelet glycoprotein IIb/IIIa receptor antagonist, DMP754: receptor binding affinity and specificity. Coron Artery Dis 1996; 7: 767-74
    • (1996) Coron. Artery Dis. , vol.7 , pp. 767-774
    • Mousa, S.A.1    Forsythe, M.2    Lorelli, W.3
  • 25
    • 0032878887 scopus 로고    scopus 로고
    • Intravenous and oral antithrombotic efficacy of the novel platelet GPIIb/IIIa antagonist roxifiban (DMP754) and its free acid form, XV459
    • Mousa SA, Kapil R, Mu DX. Intravenous and oral antithrombotic efficacy of the novel platelet GPIIb/IIIa antagonist roxifiban (DMP754) and its free acid form, XV459. Arterioscler Thromb Vasc Biol 1999; 19: 2535-41
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 2535-2541
    • Mousa, S.A.1    Kapil, R.2    Mu, D.X.3
  • 26
    • 0009499498 scopus 로고
    • Antiplatelet effects of direct thrombi inhibitors versus GPIIb/IIIa receptor antagonists: Comparative analysis
    • Gallo LL, editor. New York (NY): Plenum Press
    • Mousa S, Reilly TM. Antiplatelet effects of direct thrombi inhibitors versus GPIIb/IIIa receptor antagonists: comparative analysis. In: Gallo LL, editor. Cardiovascular disease: cellular and molecular mechanisms, prevention, treatment. New York (NY): Plenum Press, 1995: 255-267
    • (1995) Cardiovascular Disease: Cellular and Molecular Mechanisms, Prevention, Treatment , pp. 255-267
    • Mousa, S.1    Reilly, T.M.2
  • 27
    • 0006870550 scopus 로고    scopus 로고
    • Platelet activation in patients after an acute coronary syndrome: Results from the TIMI-12 trial: Thrombolysis in myocardial infarction
    • Cannon CP, Mitchell J, McCahan J, et al. Platelet activation in patients after an acute coronary syndrome: results from the TIMI-12 trial: thrombolysis in myocardial infarction. J Am Coll Cardiol 1999; 33: 634-9
    • (1999) J. Am. Coll. Cardiol. , vol.33 , pp. 634-639
    • Cannon, C.P.1    Mitchell, J.2    McCahan, J.3
  • 28
    • 0036198867 scopus 로고    scopus 로고
    • Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis
    • Apr
    • Mousa SA, Abulencia JP, McCarty OJ, et al. Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis. J Cardiovasc Pharmacol 2002 Apr; 39 (4): 552-60
    • (2002) J. Cardiovasc. Pharmacol. , vol.39 , Issue.4 , pp. 552-560
    • Mousa, S.A.1    Abulencia, J.P.2    McCarty, O.J.3
  • 29
    • 0032212143 scopus 로고    scopus 로고
    • Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (IIbbeta3) inhibitors
    • Peter K, Schwarz M, Ylanne J, et al. Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (IIbbeta3) inhibitors. Blood 1998; 92: 3240-9
    • (1998) Blood , vol.92 , pp. 3240-3249
    • Peter, K.1    Schwarz, M.2    Ylanne, J.3
  • 30
    • 0035908999 scopus 로고    scopus 로고
    • Dissociation of glycoprotein IIb/IIIa antagonists from platelets does not result in fibrinogen binding or platelet aggregation
    • Sep 18
    • Frelinger III AL, Furman MI, Krueger LA, et al. Dissociation of glycoprotein IIb/IIIa antagonists from platelets does not result in fibrinogen binding or platelet aggregation. Circulation 2001 Sep 18; 104 (12): 1374-9
    • (2001) Circulation , vol.104 , Issue.12 , pp. 1374-1379
    • Frelinger A.L. III1    Furman, M.I.2    Krueger, L.A.3
  • 31
    • 0034604123 scopus 로고    scopus 로고
    • Long-term treatment with a platelet glycoprotein-receptor antagonist after percutaneous coronary revascularization. EXCITE Trial Investigators: Evaluation of oral xemilofiban in controlling thrombotic events
    • O'Neill WW, Serruys P, Knudtson M, et al. Long-term treatment with a platelet glycoprotein-receptor antagonist after percutaneous coronary revascularization. EXCITE Trial Investigators: Evaluation of oral xemilofiban in controlling thrombotic events. N Engl J Med 2000; 342: 1316-24
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1316-1324
    • O'Neill, W.W.1    Serruys, P.2    Knudtson, M.3
  • 32
    • 17944393494 scopus 로고    scopus 로고
    • Oral glycoprotein IIb/IIIa inhibition with orbofiban in patients with unstable coronary syndromes (OPUS-TIMI 16) trial
    • Cannon CP, McCabe CH, Wilcox RG, et al. Oral glycoprotein IIb/IIIa inhibition with orbofiban in patients with unstable coronary syndromes (OPUS-TIMI 16) trial. Circulation 2000; 102: 149-56
    • (2000) Circulation , vol.102 , pp. 149-156
    • Cannon, C.P.1    McCabe, C.H.2    Wilcox, R.G.3
  • 33
    • 0034728088 scopus 로고    scopus 로고
    • Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: A randomised trial
    • SYMPHONY Investigators (9201)
    • SYMPHONY Investigators . Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: a randomised trial. Lancet 2000; 355 (9201): 337-45
    • (2000) Lancet , vol.355 , pp. 337-345
  • 34
    • 0005750230 scopus 로고    scopus 로고
    • BRAVO trial stopped: Lotrafiban increases mortality
    • Available from URL
    • Hughes S. BRAVO trial stopped: lotrafiban increases mortality. Available from URL: http://www.theheart.org/index.cfm
    • Hughes, S.1
  • 35
    • 0037118664 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa inhibitors: Recognition of a two-edged sword?
    • Jul 16
    • Quinn MJ, Plow EF, Topol EJ. Platelet glycoprotein IIb/IIIa inhibitors: recognition of a two-edged sword? Circulation 2002 Jul 16; 106 (3): 379-85
    • (2002) Circulation , vol.106 , Issue.3 , pp. 379-385
    • Quinn, M.J.1    Plow, E.F.2    Topol, E.J.3
  • 36
    • 0031808541 scopus 로고    scopus 로고
    • Oral inhibitors of platelet membrane receptor glycoprotein IIB/IIIa in clinical cardiology: Issues and opportunities
    • May
    • Theroux P. Oral inhibitors of platelet membrane receptor glycoprotein IIB/IIIa in clinical cardiology: issues and opportunities. Am Heart J 1998 May; 135 (5 Pt 2 Su): S107-12
    • (1998) Am. Heart J. , vol.135 , Issue.5 PART 2 SUPPL.
    • Theroux, P.1
  • 37
    • 0032477682 scopus 로고    scopus 로고
    • Oral platelet glycoprotein IIb/IIIa receptor antagonists: The present challenge is safety
    • Vorchheimer DA, Fuster V. Oral platelet glycoprotein IIb/IIIa receptor antagonists: the present challenge is safety. Circulation 1998; 97: 312-4
    • (1998) Circulation , vol.97 , pp. 312-314
    • Vorchheimer, D.A.1    Fuster, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.