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Volumn 8, Issue 7-8, 1998, Pages 392-399

Rational drug design of orally active influenza neuraminidase inhibitors: Discovery and development of GS 4104

Author keywords

[No Author keywords available]

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; GLYCEROL; OSELTAMIVIR; PRODRUG; SIALIC ACID; SIALIDASE INHIBITOR; VIRUS SIALIDASE;

EID: 0037976524     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (7)

References (13)
  • 1
    • 0020334815 scopus 로고
    • Serious morbidity and mortality associated with influenza epidemics
    • Glezan, W. P. Serious morbidity and mortality associated with influenza epidemics. Epidemiol. Rev. 1982, 4, 25-44.
    • (1982) Epidemiol. Rev. , vol.4 , pp. 25-44
    • Glezan, W.P.1
  • 2
    • 0002988267 scopus 로고
    • The action of adamantamines against influenza A viruses: Inhibition of the M2 ion channel protein
    • Hay, A. J. The action of adamantamines against influenza A viruses: Inhibition of the M2 ion channel protein. Semin. Virol. 1992, 3, 21-30.
    • (1992) Semin. Virol. , vol.3 , pp. 21-30
    • Hay, A.J.1
  • 4
    • 0016272701 scopus 로고
    • Characterization of temperature sensitive influenza virus mutants defective in neuraminidase
    • Palese, P.; Tobita, K.; Ueda, M.; Compans, R.W. Characterization of temperature sensitive influenza virus mutants defective in neuraminidase. Virol. 1974, 61, 397-410
    • (1974) Virol. , vol.61 , pp. 397-410
    • Palese, P.1    Tobita, K.2    Ueda, M.3    Compans, R.W.4
  • 5
    • 0027930960 scopus 로고
    • Structure of influenza virus neuraminidase B/Lee/40 complexed with sialic acid and a dehydro analog at 1.8Å resolution: Implication for the catalytic mechanism
    • Janakiraman, M. N.; White, C. L.; Laver, W. G.; Air, G. M. Structure of influenza virus neuraminidase B/Lee/40 complexed with sialic acid and a dehydro analog at 1.8Å resolution: Implication for the catalytic mechanism. Biochemistry 1994, 33, 8172-8179.
    • (1994) Biochemistry , vol.33 , pp. 8172-8179
    • Janakiraman, M.N.1    White, C.L.2    Laver, W.G.3    Air, G.M.4
  • 7
    • 0028325249 scopus 로고
    • Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis
    • Taylor, N. R.; Von Itzstein, M. Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis. J. Med. Chem. 1994, 37, 616-624.
    • (1994) J. Med. Chem. , vol.37 , pp. 616-624
    • Taylor, N.R.1    Von Itzstein, M.2
  • 10
  • 11
    • 0031048319 scopus 로고    scopus 로고
    • Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity
    • Kim, C. U.; Lew, W.; Williams, M. A.; Liu, H.; Zhang, L.; Swaminathan, S.; Bischofberger, N.; Chen, M. S.; Mendel, D. B.; Tai, C. Y.; Laver, W. G.; Stevens, R. C. Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J. Amer, Chem. Soc. 1997, 119, 681-690.
    • (1997) J. Amer, Chem. Soc. , vol.119 , pp. 681-690
    • Kim, C.U.1    Lew, W.2    Williams, M.A.3    Liu, H.4    Zhang, L.5    Swaminathan, S.6    Bischofberger, N.7    Chen, M.S.8    Mendel, D.B.9    Tai, C.Y.10    Laver, W.G.11    Stevens, R.C.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.