3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: Synthesis and evaluation as CFTR activators

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 15, 2003, Pages 2509-2512

  Sammelson, Robert E ^a   Ma, T ^b   Galietta, Luis J V ^c   Verkman, A S ^b   Kurth, Mark J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c G GASLINI INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE; CHEMICAL COMPOUND; CHLORIDE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; HALIDE; ISOXAZOLE DERIVATIVE; ISOXAZOLINE DERIVATIVE; OXIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ALKYLATION; ANIMAL; ARTICLE; BINDING SITE; BIOTRANSFORMATION; CELL ASSAY; CHLORIDE TRANSPORT; CYCLOADDITION; DRUG EFFECT; ELECTRON TRANSPORT; EVALUATION; FLUORESCENCE; GENETICS; HUMAN; METABOLISM; MUTATION; PHYSIOLOGY; RAT; RAT STRAIN; STIMULATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

EID: 0037971989     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00482-7     Document Type: Article

References (16)

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13. Percent in parenthesis for all figures and Schemes provide the relative CFTR activation where the activation for genistein, a known activator, is standardized to 100%.
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