Isolation of an unknown metabolite of capecitabine, an oral 5-fluorouracil prodrug, and its identification by nuclear magnetic resonance and liquid chromatography-tandem mass spectrometry as a glucuroconjugate of 5′-deoxy-5-fluorocytidine, namely 2′-(β-D-glucuronic acid)-5′-deoxy-5-fluorocytidine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 792, Issue 2, 2003, Pages 323-332

  Desmoulin, Franck ^a,b   Gilard, Véronique ^a   Martino, Robert ^a   Malet Martino, Myriam ^a  

^a Université Paul Sabatier   (France)

^b UPS)   (France)

Author keywords

5 Fluorouracil; 5 Deoxy 5 fluorocytidine; Capecitabine

Indexed keywords

DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SEPARATION; TUMORS;

LIQUID-LIQUID SEPARATION;

BIOMEDICAL ENGINEERING;

2' (BETA DEXTRO GLUCURONIC ACID) 5' DEOXY 5 FLUOROCYTIDINE; 5' DEOXY 5 FLUOROCYTIDINE; ANTINEOPLASTIC AGENT; BETA GLUCURONIDASE; CAPECITABINE; CHEMICAL COMPOUND; CHLORIDE; CYTIDINE DERIVATIVE; FLUOROURACIL; OCTADECYLSILANE; PRODRUG; SILANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COLUMN CHROMATOGRAPHY; CONJUGATION; CONTROLLED STUDY; DRUG PURIFICATION; FLUORINATION; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METABOLITE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TANDEM MASS SPECTROMETRY;

EID: 0037969390     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(03)00319-2     Document Type: Article

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