S-nitrosylated polyethylene glycol-conjugated hemoglobin derivative as a candidate material for oxygen therapeutics

Advances in Experimental Medicine and Biology

Volumn 519, Issue , 2003, Pages 207-216

  Nakai, Kunihiko ^a   Sakuma, Ichiro ^b   Togashi, Hiroko ^b   Yoshioka, Mitsuhiro ^b   Sugawara, Takeshi ^b   Satoh, Hiroshi ^a   Kitabatake, Akira ^b  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG CARRIER; HEMOGLOBIN DERIVATIVE; MACROGOL DERIVATIVE; NITRIC OXIDE; S NITROSOHEMOGLOBIN; S NITROSOTHIOL; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DRUG EFFICACY; DRUG SAFETY; DRUG SYNTHESIS; HUMAN; HYPERTENSION; LIVER TOXICITY; NEPHROTOXICITY; NONHUMAN; OXYGEN THERAPY; OXYGEN TRANSPORT; PRIORITY JOURNAL;

ANIMALS; BLOOD PRESSURE; BLOOD SUBSTITUTES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEMOGLOBINS; HUMANS; OXYGEN; POLYETHYLENE GLYCOLS;

EID: 0037957180     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (17)

1. Nakai K, Sakuma I, Satoh H, Kitabatake A. Vascular activities of hemoglobin-based oxygen carriers: relationship between vasoconstrictive activity and endothelial permeability. In: Kitabatake A, Sakuma I. (eds). Recent Advances in Nitric Oxide Research. Tokyo: Springer-Verlag Tokyo; 1998. p. 33-45.
2. Jia L, Bonaventura C, Bonaventura J, Stamler J. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 1996; 380:221-226.
3. Stamler JS, Jia L, Eu JP, McMahon TJ, Demchenko IT, Bonaventura J, et al. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science 1997; 276:2034-3037.
4. Pawloski JR, Swaminathan RV, Stamler JS. Cell-free and erythrocytic S-nitrosohemoglobin inhibits human platelet aggregation. Circulation 1998; 97:263-267.
5. Nakai K, Hiroko T, Yasukohchi T, Sakuma I, Fujii S, Yoshioka M, et al. Preparation and characterization of SNO-PEG-hemoglobin as a candidate for oxygen transporting material. Int J Artif Organs 2001; 24:322-328.
6. Akaike T, Inoue K, Okamoto T, Nishino H, Otagiri M, Fujii S, et al. Nanomolar quantification and identification of various nitrosothiols by high performance liquid chromatography coupled with flow reactors of metals and Griess reagent. J Biochem 1997; 122:459-466.
7. Keipert PE, Gonzales A, Gomez CL, MacDonald VW, Hess JR, Winslow RM. Acute changes in systemic blood pressure and urine output of conscious rats following exchange transfusion with diaspirin-crosslinked hemoglobin solution Transfusion 1993; 33:701-708.
8. Rioux F, Petitclerc E, Audet R, Drapeau G, Fielding RM, Marceau F. Recombinant human hemoglobin inhibits both constitutive and cytokine-induced nitric oxide-mediated relaxation of rabbit isolated aortic rings. J Cardiovasc Pharmacol 1994; 24:229-237.
9. Nakai K, Ohta T, Sakuma I, Akama K, Kobayashi Y, Tokuyama S, et al. Inhibition of endothelium-dependent relaxation by hemoglobin in rabbit aortic strips: Comparison between acellular hemoglobin derivatives and cellular hemoglobins. J Cardiovasc Pharmacol 1996; 28:115-123.
10. Hoshi Y, Hazeki O, Kakihana Y, Tamura M. Redox behavior of cytochrome oxidase in the rat brain measured by near-infrared spectroscopy. J Appl Physiol 1997; 83:1842-8.
11. Matsushita M, Yabuki A, Chen J, Takahashi T, Harasaki H, Malchesky PS, et al. Renal effects of a pyridoxalated-hemoglobin-polyoxyethylene conjugate solution as a blood substitute in exchange transfusions. Trans. Am. Soc. Artif. Intern. Organs 1988; 34:280-283.
12. Xu L, Eu JP, Meissner G, Stamler JS. Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science 1998; 279:234-237.
13. Ikebe N, Akaike T, Miyamoto Y, Hayashida K, Yoshitake J, Ogawa M, et al. Protective effect of S-nitrosylated α1-protease inhibitor on hepatic ischemia-reperfusion injury. J Pharamacol Exp Ther 2000; 295:904-911.
14. Marshall HE, Stamler JS. Inhibition of NF-kB by S-nitrosylation. Biochemistry 2001; 40:1688-1693.
15. Li X, Rose G, Dongre N, Pan H-L, Tobin JR, Eisenach JC. S-nitroso-1-cysteine releases norepinephrine in rat spinal synaptosomes. Brain Res 2000; 872:301-307.
16. Ramachandran N, Root P, Jiang XM, Hogg PJ, Mutus B. Mechanism of transfer of NO from extracellular S-nitrosothiols into the cytosol by cell-surface protein disulfide isomerase. Proc Natl Acad Sci USA 2001; 97:9539-9544.
17. Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature 2001; 410:490-494.