Hematopoietic capacity of connexin43 wild-type and knock-out fetal liver cells not different on wild-type stroma

Blood

Volumn 101, Issue 8, 2003, Pages 2996-2998

  Rosendaal, Martin ^a,b   Jopling, Chris ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; GLUCOSE 6 PHOSPHATE ISOMERASE; CONNEXIN 45; FLUOROURACIL; GAP JUNCTION PROTEIN; PHENYLHYDRAZINE; PHENYLHYDRAZINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL POPULATION; CONTROLLED STUDY; EMBRYO; FETUS; GAP JUNCTION; GENE DELETION; GENOTYPE; HEMATOPOIESIS; HEMATOPOIETIC CELL; HEMIZYGOSITY; KNOCKOUT MOUSE; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STROMA; WILD TYPE; ANIMAL; CELL COMMUNICATION; CELL JUNCTION; CLONOGENIC ASSAY; CONGENIC STRAIN; CYTOLOGY; EXTRAMEDULLARY HEMATOPOIESIS; GENETIC MARKER; GENETICS; HEMATOPOIETIC STEM CELL; LIVER; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; PRENATAL DEVELOPMENT; STROMA CELL;

ANIMALS; ANIMALS, CONGENIC; CELL COMMUNICATION; COLONY-FORMING UNITS ASSAY; CONNEXIN 43; CONNEXINS; FLUOROURACIL; GAP JUNCTIONS; GENETIC MARKERS; GENOTYPE; GLUCOSE-6-PHOSPHATE ISOMERASE; HEMATOPOIESIS, EXTRAMEDULLARY; HEMATOPOIETIC STEM CELLS; LIVER; MICE; MICE, KNOCKOUT; PHENYLHYDRAZINES; STROMAL CELLS;

EID: 0037944128     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-07-2028     Document Type: Article

References (22)

1. Rosendaal M, Mayen A, de Koning A, Dunina-Barkovskaya T, Krenacs T, Ploemacher R. Does transmembrane communication through gap junctions enable stem cells to overcome stromal inhibition? Leukemia. 1997;11:1281-1289.
2. Porvaznik M, MacVittie TJ. Detection of gap junctions between the progeny of a canine macrophage colony-forming cell in vitro. J Cell Biol. 1979;82:555-564.
3. Rosendaal M, Gregan A, Green CR. Direct cell-cell communication in the blood-forming system. Tissue Cell. 1991;23:457-470.
4. Dorshkind K, Green L, Godwin A, Fletcher WH. Connexin-43-type gap junctions mediate communication between bone marrow stromal cells. Blood. 1993;82:38-45.
5. Rosendaal M, Green CR, Rahman A, Morgan D. Up-regulation of the connexin43+ gap junction network in haemopoietic tissue before the growth of stem cells. J Cell Sci. 1994;107:29-37.
6. Alves LA, Campos de Carvalho AC, Cirne Lima EO, et al. Functional gap junctions in thymic epithelial cells are formed by connexin 43. Eur J Immunol. 1995;25:431-437.
7. Krenacs T, Rosendaal M. Immunohistological detection of gap junctions in human lymphoid tissue: connexin43 in follicular dendritic and lymphoendothelial cells. J Histochem Cytochem. 1995;43:1125-1137.
8. Krenacs T, van Dartel M, Lindhout E, Rosendaal M. Direct cell/cell communication in the lymphoid germinal center: connexin43 gap junctions functionally couple follicular dendritic cells to each other and to B lymphocytes. Eur J Immunol. 1997;27:1489-1497.
9. Krenacs T, Rosendaal M. Gap-junction communication pathways in germinal center reactions. Dev Immunol. 1998;6:111-118.
10. Krenacs T, Rosendaal M. Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formation. Am J Pathol. 1998;152:993-1004.
11. Cancelas JA, Koevoet WL, de Koning AE, Mayen AE, Rombouts EJ, Ploemacher RE. Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells. Blood. 2000;96:498-505.
12. Ploemacher RE, Mayen AE, De Koning AE, Krenacs T, Rosendaal M. Hematopoiesis: gap junction intercellular communication is likely to be involved in regulation of stroma-dependent proliferation of hemopoietic stem cells. Hematology. 2000;5:133-147.
13. Bruzzone R, White TW, Paul DL. Connections with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem. 1996;238:1-27.
14. Rosendaal M. Gap junctions in blood forming tissues. Microsc Res Tech. 1995;31:396-407.
15. , Reaume AG, de Sousa PA, Kulkarni S, et al. Cardiac malformation in neonatal mice lacking connexin43. Science. 1995;267:1831-1834.
16. Harrison DE. Competitive repopulation: a new assay for long-term stem cell functional capacity. Blood. 1980;55:77-81.
17. Martyn KD, Kurata WE, Warn CB, Burt JM, Ten-Broek E, Lau AF. Immortalized connexin43 knockout cell lines display a subset of biological properties associated with the transformed phenotype. Cell Growth Differ. 1997;8:1015-1027.
18. Stewart WW. Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. Cell. 1978;14:741-759.
19. Jopling C, Rosendaal M. A cautionary tale: how to delete mouse haemopoietic stem cells with busulphan. Br J Haematol. 2001;113:970-974.
20. Hodgson GS, Bradley TR. Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: evidence for a pre-CFU-S cell? Nature. 1979;281:381-382.
21. Bradley TR, Hodgson GS. Detection of primitive macrophage progenitor cells in mouse bone marrow. Blood. 1979;54:1446-1450.
22. Montecino RE, Leathers H, Dorshkind K. Expression of connexin 43 (Cx43) is critical for normal hematopoiesis. Blood. 2000;96:917-924.