Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in rats

Human Gene Therapy

Volumn 14, Issue 9, 2003, Pages 861-869

  Vieillard Baron, Antoine ^a,b   Frisdal, Eric ^a   Raffestin, Bernadette ^a,b   Baker, Andrew H ^c   Eddahibi, Saadia ^a   Adnot, Serge ^a,d   D'ortho, Marie Pia ^a,d  

^a INSERM   (France)

^b HÔPITAL AMBROISE PARÉ   (France)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d HENRI MONDOR HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; COLLAGEN; ELASTIN; MATRIX METALLOPROTEINASE; MONOCROTALINE; PROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ADENOVIRUS MEDIATED TISSUE INHIBITOR OF METALLOPROTEINASE 1 GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; GENE; GENE TRANSFER; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXIA; LUNG ALVEOLUS CELL; LUNG BLOOD VESSEL; NONHUMAN; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; ZYMOGRAPHY;

ADENOVIRIDAE; ANIMALIA;

EID: 0037942873     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303403765701150     Document Type: Article

References (34)

1. BAKER, A.H., WILKINSON, G.W., HEMBRY, R.M., MURPHY, G., and NEWBY, A.C. (1996). Development of recombinant adenoviruses that drive high level expression of the human metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and -2 genes: Characterization of their infection into rabbit smooth muscle cells and human MCF-7 adenocarcinoma cells. Matrix Biol. 15, 383-395.
2. BAKER, A.H., ZALTSMAN, A.B., GEORGE, S.J., and NEWBY, A.C. (1998). Divergent effects of Tissue Inhibitor of Metalloproteinase-1, -2, -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. J. Clin. Invest. 101, 1478-1487.
3. BENDECK, M.P., ZEMPO, N., CLOWES, A.W., GALARDY, R.E., and REIDY, M.A. (1994). Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat. Circ. Res. 75, 539-545.
4. CAVARRA, E., MARTORANA, P.A., GAMBELLI, F., DE SANTI, M., VAN EVEN, P., and LUNGARELLA, G. (1996). Neutrophil recruitment into lungs is associated with increased lung elastase burden, decreased lung elastin, and emphysema in alpha 1 proteinase inhibitor-deficient mice. Lab. Invest. 75, 273-280.
5. COWAN, K.N., HEILBUT, A., HUMPL, T., LAM, C., ITO, S., and RABINOVITCH, M. (2000a). Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nat. Med. 6, 698-702.
6. COWAN, K.N., JONES, P.L., and RABINOVITCH, M. (2000b). Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease. J. Clin. Invest. 105, 21-34.
7. DESROCHERS, P.E., JEFFREY, J.J., and WEISS S.J. (1991). Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity. J. Clin. Invest. 87, 2258-2265.
8. FOROUGH, R., KOYAMA, N., HASENSTAB, D., LEA, H., CLOWES, M., NIKKARI, S.T., and CLOWES, A.W. (1996). Over-expression of tissue inhibitor of matrix metalloproteinase-1 inhibits vascular smooth muscle cell function in vitro and in vivo. Circ. Res. 79, 812-820.
9. FRISDAL, E., GEST, V., VIEILLARD-BARON, A., EDDAHIBI, S., LEVAME, M., LAFUMA, C., HARF, A., ADNOT, S., and D'ORTHO, M. (2001). Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension. Eur. Respir. J. 8, 838-845.
10. GALIS, Z.S., SUKHOVA, G.K., and LIBBY, P. (1995). Microscopic localization of active protease by in situ zymography: Detection of matrix metalloproteinase activity in vascular tissue. FASEB J. 9, 874-980.
11. GEORGE, S.J., JOHNSON, J.L., ANGELINI, G.D., NEWBY, A.C., and BAKER, A.H. (1998). Adenovirus-mediated gene transfer of the human TIMP-1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein. Hum. Gene Ther. 9, 867-877.
12. GIBBONS, G.H., and DZAU, V.J. (1994). The emerging concept of vascular remodeling. N. Engl. J. Med. 330, 1431-1438.
13. GIBBS, D.F., WARNER, R.L., WEISS, S.J., JOHNSON, K.J., and VARANI, J. (1999). Characterization of matrix metalloproteinases produced by rat alveolar macrophages. Am. J. Respir. Cell. Mol. Biol. 20, 1136-1144.
14. HEAT, D. (1993). The pathology of pulmonary hypertension. Eur. Respir. Rev. 3, 555-558.
15. JONES, P.L., CRACK, J., and RABINOVITCH, M. (1997). Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the avb3 integrin to promote epidermal growth factor receptor phosphorylation and growth. J. Cell Biol. 139, 279-293.
16. LEE, K.M., TSAI, K.Y., WANG, N., and NGBER, D.E. (1998). Extracellular matrix and pulmonary hypertension: Control of vascular smooth muscle cell contractility. Am. J. Physiol. 274, H76-82.
17. LI, D.Y., FAURY, G., TAYLOR, D.G., DAVIS, E.C., BOYLE, W.A., MECHAM, R.P., STENZEL, P., BOAK, B., and KEATING, M.T. (1998). Novel arterial pathology in mice and humans hemizygous for elastin. J. Clin. Invest. 102, 1783-1787.
18. MECHAM, R., WHITEHOUSE, L., WRENN, D., PARKS, W., GRIFFIN, G., SENIOR, R., CROUCH, E., STENMARK, K., and VOELKEL, N. (1987). Smooth muscle-mediated connective tissue remodeling in pulmonary hypertension. Science 237, 423-6.
19. MEYRICK, B., and REID, L. (1980). Hypoxia-induced structural changes in the media and adventitia of the rat hilar pulmonary artery and their regression. Am. J. Pathol. 100, 151-178.
20. MURPHY, G., and DOCHERTY, A.J.P. (1992). The matrix metalloproteinases and their inhibitors. Am. J. Respir. Cell. Mol. Biol. 7, 120-125.
21. OKADA, Y., WATANABE, S., NAKANISHI, I., KISHI, J., HAGAKAWA, T., WATOREK, W., TRAVIS, J., and NAGASE, H. (1988). Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinases. FEBS Lett. 229, 1157-1160.
22. PARTOVIAN, C., ADNOT, S., EDDAHIBI, S., TEIGER, E., LEVAME, M., DREYFUS, P., RAFFESTIN, B., and FRELIN, C. (1998). Heart and lung VEGF mRNA expression in rats with monocrotaline- or hypoxia-induced pulmonary hypertension. Am. J. Physiol. 275, H1948-H1956.
23. POIANI, G.J., TOZZI, C.A., YOHN, S.E., PIERCE, R.A., BELSKY, S.A., BERG, R.A., YU, S.Y., DEAK, S.B., and RILEY, D.J. (1990). Collagen and elastin metabolism in hypertensive pulmonary arteries of rats. Circ. Res. 66, 968-978.
24. RABINOVITCH, M., GAMBLE, W., NADAS, A.S., MIETTINEN, O.S., and REID, L. (1979). Rat pulmonary circulation after chronic hypoxia: Hemodynamic and structural features. Am. J. Physiol. 236, H818-H827.
25. RABINOVITCH, M., GAMBLE, W., MIETTINEN, O.S., and REID, L. (1981). Age and sex influence on pulmonary hypertension of chronic hypoxia and on recovery. Am. J. Physiol. 240, H62-H72.
26. RILEY, D., THAKKER-VARIA, S., WILSON, F., POIANI, G., and TOZZI, C. (2000). Role of proteolysis and apoptosis in regression of pulmonary vascular remodeling. Physiol. Res. 49, 577-585.
27. SCHNAPER, H.W., GRANT, D.S., and STETLER-STEVENSON, W.G. (1993). Type IV collagenase (s) and TIMPs modulate endothelial cell morphogenesis in vitro. J. Cell. Physiol. 156, 235-246.
28. SENIOR, R.M., GRIFFIN, G., MECHAM, R.P., WRENN, D.S., PRASAD, K.U., and URRY, D.W. (1984). Val-Gly-Val-Ala-ProGly, a repeating peptide in elastin is chemotactic for fibroblasts and monocytes. J. Cell Biol. 99, 870-874.
29. SENIOR, R.M., GRIFFIN, G.L., FLISZAR, C.J., SHAPIRO, S.D., GOLDBERG, G.I., and WELGUS, H.G. (1991). Human 92- and 72-kilodalton type IV collagenases are elastases. J. Biol. Chem. 25, 7870-7875.
30. SOUTHGATE, K.M., DAVIES, M., BOOTH, R.F., and NEWBY, A.C. (1992). Involvement of extracellular-matrix-degrading metalloproteinases in rabbit aortic smooth-muscle cell proliferation. Biochem. J. 288, 93-99.
31. SOUTHGATE, K.M., FISHER, M., BANNING, A.P., THURSTON, V.J., and BAKER, A.H. (1996). Upregulation of basement membrane-degrading metalloproteinase secretion after balloon injury of pig carotid arteries. Circ. Res. 79, 1177-1187.
32. TAIPALE, J., and KESKI-OJA, J. (1997). Growth factors in the extracellular matrix. FASEB J. 11, 51-59.
33. VIEILLARD-BARON, A., FRISDAL, E., EDDAHIBI, S., DEPREZ, I., BAKER, A.H., NEWBY, A.C., BERGER, P., LEVAME, M., RAFFESTIN, B., ADNOT, S., and D'ORTHO, M. (2000). Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer or doxycycline aggravates pulmonary hypertension in rats. Circ. Res. 87, 418-425.
34. ZEMPO, N., KENAGY, R.D., BENDECK, M., CLOWES, M.M., REIDY, M.A., and CLOWES, A.W. (1994). Matrix metalloproteinases of vascular wall cells are increased in balloon-injured rat carotid. J. Vasc. Surg. 20, 209-217.