Solid-phase synthesis of five-dimensional libraries via a tandem Petasis-Ugi multi-component condensation reaction

Tetrahedron Letters

Volumn 44, Issue 27, 2003, Pages 5121-5124

  Portlock, David E ^a   Naskar, Dinabandhu ^b   West, Laura ^a   Ostaszewski, Ryszard ^c   Chen, Jack J ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^b Chembiotek Research International   (India)

^c WARSAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ISONITRILE DERIVATIVE;

ARTICLE; AUTOMATION; COLUMN CHROMATOGRAPHY; POLYMERIZATION; PURIFICATION; SOLID; STEREOCHEMISTRY; SYNTHESIS; VALIDATION PROCESS;

EID: 0037938842     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)01119-5     Document Type: Article

References (22)

1. For leading references, see: (a) Nicolaou, K. C.; Hanko, R.; Hartwig, W. Handbook of Combinatorial Chemistry; Wiley-VCH: Weinheim, 2002; Vols. 1 and 2; (b) Edwards, P. J.; Morrell, A. I. Curr. Opin. Drug Discov. Devel. 2002, 5, 594; (c) Dolle, R. E. J. Combi. Chem. 2002, 4, 369.
2. For leading references, see: (a) Nicolaou, K. C.; Hanko, R.; Hartwig, W. Handbook of Combinatorial Chemistry; Wiley-VCH: Weinheim, 2002; Vols. 1 and 2; (b) Edwards, P. J.; Morrell, A. I. Curr. Opin. Drug Discov. Devel. 2002, 5, 594; (c) Dolle, R. E. J. Combi. Chem. 2002, 4, 369.
3. For leading references, see: (a) Nicolaou, K. C.; Hanko, R.; Hartwig, W. Handbook of Combinatorial Chemistry; Wiley-VCH: Weinheim, 2002; Vols. 1 and 2; (b) Edwards, P. J.; Morrell, A. I. Curr. Opin. Drug Discov. Devel. 2002, 5, 594; (c) Dolle, R. E. J. Combi. Chem. 2002, 4, 369.
4. For reviews, see: (a) Golebiowski, A.; Klopfenstein, S. R.; Portlock, D. E. Curr. Opin. Chem. Biol. 2001, 5, 273 and references cited therein; (b) Wennemers, H. Combin. Chem. HTS 2001, 4, 273; (c) Dagani, R. Chem. Eng. News 2001, 27 Aug, 59.
5. For reviews, see: (a) Golebiowski, A.; Klopfenstein, S. R.; Portlock, D. E. Curr. Opin. Chem. Biol. 2001, 5, 273 and references cited therein; (b) Wennemers, H. Combin. Chem. HTS 2001, 4, 273; (c) Dagani, R. Chem. Eng. News 2001, 27 Aug, 59.
6. For reviews, see: (a) Golebiowski, A.; Klopfenstein, S. R.; Portlock, D. E. Curr. Opin. Chem. Biol. 2001, 5, 273 and references cited therein; (b) Wennemers, H. Combin. Chem. HTS 2001, 4, 273; (c) Dagani, R. Chem. Eng. News 2001, 27 Aug, 59.
7. Domling A. Curr. Opin. Chem. Biol. 6:2002;306.
8. Ugi I., Heck S. Combin. Chem. HTS. 4:2001;1.
9. Domling A., Ugi I. Angew. Chem., Int. Ed. 39:2000;3168.
10. Bienayme H., Hulme C., Oddon G., Schmidt P. Chem. Eur. J. 6:2000;3321.
11. Constabel F., Ugi I. Tetrahedron. 57:2001;5785.
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13. Domling A., Ugi I. Angew. Chem., Int. Ed. 39:2000;3168. and references cited therein.
14. The concept of a tandem Petasis-Ugi multi-component condensation has been disclosed by us previously, see: (a) CHI's Seventh Annual High Throughput Organic Synthesis Symposium, 'Synthesis of Thematic Libraries for a Platform Target-Based Approach to Drug Discovery', 13-15 Feb., 2002, San Diego, CA; (b) Portlock, D. E.; Naskar, D.; West, L.; Li, M. Tetrahedron Lett. 2002, 43, 6845; (c) Portlock, D. E.; Ostaszewski, R.; Naskar, D.; West, L. Tetrahedron Lett. 2003, 44, 603.
15. The concept of a tandem Petasis-Ugi multi-component condensation has been disclosed by us previously, see: (a) CHI's Seventh Annual High Throughput Organic Synthesis Symposium, 'Synthesis of Thematic Libraries for a Platform Target-Based Approach to Drug Discovery', 13-15 Feb., 2002, San Diego, CA; (b) Portlock, D. E.; Naskar, D.; West, L.; Li, M. Tetrahedron Lett. 2002, 43, 6845; (c) Portlock, D. E.; Ostaszewski, R.; Naskar, D.; West, L. Tetrahedron Lett. 2003, 44, 603.
16. The concept of a tandem Petasis-Ugi multi-component condensation has been disclosed by us previously, see: (a) CHI's Seventh Annual High Throughput Organic Synthesis Symposium, 'Synthesis of Thematic Libraries for a Platform Target-Based Approach to Drug Discovery', 13-15 Feb., 2002, San Diego, CA; (b) Portlock, D. E.; Naskar, D.; West, L.; Li, M. Tetrahedron Lett. 2002, 43, 6845; (c) Portlock, D. E.; Ostaszewski, R.; Naskar, D.; West, L. Tetrahedron Lett. 2003, 44, 603.
17. +].
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21. Chen J.J., Golebiowski A., Klopfenstein S.R., West L. Tetrahedron Lett. 43:2002;4083.
22. Chen J.J., Golebiowski A., McClenagham J., Klopfenstein S.R. Tetrahedron Lett. 42:2001;2269.